Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Wei-Wei Kung"'
Autor:
Anamarija Jurisic, Pei‐Ju Sung, Mark Wappett, Julien Daubriac, Ian T. Lobb, Wei‐Wei Kung, Nyree Crawford, Natalie Page, Eamon Cassidy, Stephanie Feutren‐Burton, J. S. Shane Rountree, Matthew D. Helm, Colin R. O'Dowd, Richard D. Kennedy, Gerald Gavory, Aaron N. Cranston, Daniel B. Longley, Xavier Jacq, Timothy Harrison
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 4, Pp n/a-n/a (2024)
Abstract Background Understanding how to modulate the microenvironment of tumors that are resistant to immune checkpoint inhibitors represents a major challenge in oncology.Here we investigate the ability of USP7 inhibitors to reprogram the tumor mic
Externí odkaz:
https://doaj.org/article/c9655525645b43019fcffa228b383b32
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The suppressor of cytokine signaling 2 (SOCS2) is a component of the Cullin5 E3 ubiquitin ligase complex. Here the authors provide insights into substrate recognition and specificity of SOCS2 by determining the crystal structures of the SOCS2-Elongin
Externí odkaz:
https://doaj.org/article/5f64f9c2c7dd475d9276013f7571de57
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The suppressor of cytokine signaling 2 (SOCS2) acts as substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex. SOCS2 binds to phosphotyrosine-modified epitopes as degrons for ubiquitination and proteasomal degradation, yet the molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700c4a961488f4693fc9dc2d90a8b43b
https://doaj.org/article/5f64f9c2c7dd475d9276013f7571de57
https://doaj.org/article/5f64f9c2c7dd475d9276013f7571de57