Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Wei-Shiung Lian"'
Autor:
Cheng-Hsiu Lu, Wei-Shiung Lian, Re-Wen Wu, Yu-Han Lin, Chia-Hao Su, Chuan-Lin Chen, Ming-Hong Tai, Yu-Shan Chen, Shao-Yu Wang, Chao-Cheng Chen, Feng-Sheng Wang
Publikováno v:
APL Bioengineering, Vol 8, Iss 3, Pp 036110-036110-12 (2024)
Cartilage damage, a common cause of osteoarthritis, requires medical imaging for accurate diagnosis of pathological changes. However, current instruments can acquire limited imaging information due to sensitivity and resolution issues. Therefore, mul
Externí odkaz:
https://doaj.org/article/9351c98798494bf99179ce41616565cd
Autor:
Jih-Yang Ko, Feng-Sheng Wang, Wei-Shiung Lian, Fu-Shine Yang, Jeng-Wei Chen, Po-Hua Huang, Chin-Yi Liao, Shu-Jui Kuo
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-20 (2024)
Abstract Background The current treatment of osteogenesis imperfecta (OI) is imperfect. Our study thus delves into the potential of using Dickkopf-1 antisense (DKK1-AS) to treat OI. Methods We analysed serum DKK1 levels and their correlation with lum
Externí odkaz:
https://doaj.org/article/276d3cc336804daa9c83b2dba42ea14d
Publikováno v:
Biomedical Journal, Vol 47, Iss 2, Pp 100629- (2024)
Background: Micro-ribonucleic acids (miRNAs) are involved in osteoarthritis (OA) pathogenesis and clock-controlled genes (CCGs) regulation. However, the interaction between miRNAs and CCGs remains unclear. Methods: Human OA samples were used to asses
Externí odkaz:
https://doaj.org/article/425b773f55b8496593539f2d49e0fd4d
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 470 (2024)
Imbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates the development of osteoporosis, which is the leading risk factor of disability in the elderly. Harmonizing the metabolic actions of bone-making cells and bone reso
Externí odkaz:
https://doaj.org/article/39e1afc5e1604e79b9b585a646d6ebe5
Autor:
Wei-Shiung Lian, Re-Wen Wu, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Chun-Ping Yu, Holger Jahr, Feng-Sheng Wang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-11 (2022)
Abstract Epigenome alteration in chondrocytes correlates with osteoarthritis (OA) development. H3K27me3 demethylase UTX regulates tissue homeostasis and deterioration, while its role was not yet studied in articulating joint tissue in situ. We now un
Externí odkaz:
https://doaj.org/article/6fb744a909a24bbd9777401b0e528866
Autor:
Wei-Shiung Lian, Feng-Sheng Wang, Yu-Shan Chen, Ming-Hsien Tsai, How-Ran Chao, Holger Jahr, Re-Wen Wu, Jih-Yang Ko
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 860 (2022)
Osteoporosis and osteoarthritis account for the leading causes of musculoskeletal dysfunction in older adults. Senescent chondrocyte overburden, inflammation, oxidative stress, subcellular organelle dysfunction, and genomic instability are prominent
Externí odkaz:
https://doaj.org/article/6a9759b5f87e48a28cb280066cd033c0
Autor:
Hsuan-Fu Kuo, I-Fan Liu, Chia-Yang Li, Chien-Sung Tsai, Yung-Hsiang Chen, Wei-Shiung Lian, Tzu-Chieh Lin, Yu-Ru Liu, Tsung-Ying Lee, Chi-Yuan Huang, Chong-Chao Hsieh, Chih-Hsin Hsu, Feng-Yen Lin, Po-Len Liu
Publikováno v:
Biomedicines, Vol 9, Iss 10, p 1465 (2021)
The accumulation of unknown polymorphic composites in the endocardium damages the endocardial endothelium (EE). However, the composition and role of unknown polymorphic composites in heart failure (HF) progression remain unclear. Here, we aimed to ex
Externí odkaz:
https://doaj.org/article/8fa4db3d74da4c78b65f52036554f213
Autor:
Wei-Shiung Lian, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Shao-Yu Wang, Holger Jahr, Feng-Sheng Wang
Publikováno v:
Antioxidants, Vol 10, Iss 8, p 1248 (2021)
Senescent osteoblast overburden accelerates bone mass loss. Little is understood about microRNA control of oxidative stress and osteoblast senescence in osteoporosis. We revealed an association between microRNA-29a (miR-29a) loss, oxidative stress ma
Externí odkaz:
https://doaj.org/article/6290c4d88e404015bd2de1402e25e859
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1394 (2021)
Bone-forming cells build mineralized microstructure and couple with bone-resorbing cells, harmonizing bone mineral acquisition, and remodeling to maintain bone mass homeostasis. Mitochondrial glycolysis and oxidative phosphorylation pathways together
Externí odkaz:
https://doaj.org/article/8102b905c4ca4f15b907621e245ddc4b
Autor:
Jih-Yang Ko, Mel S. Lee, Wei-Shiung Lian, Wen-Tsan Weng, Yi-Chih Sun, Yu-Shan Chen, Feng-Sheng Wang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Synovitis contributes to the development of osteoarthritis (OA) of the knee. MicroRNAs regulate joint microenvironment homeostasis and deterioration. This study was undertaken to characterize the actions of microRNA-29a (miR-29a) to synovial
Externí odkaz:
https://doaj.org/article/fa91fc2b14564efc8f14940ec11fcee4