Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Wei-Qi Wei"'
Autor:
Jonathan D. Mosley, John P. Shelley, Alyson L. Dickson, Jacy Zanussi, Laura L. Daniel, Neil S. Zheng, Lisa Bastarache, Wei-Qi Wei, Mingjian Shi, Gail P. Jarvik, Elisabeth A. Rosenthal, Atlas Khan, Alborz Sherafati, Iftikhar J. Kullo, Theresa L. Walunas, Joseph Glessner, Hakon Hakonarson, Nancy J. Cox, Dan M. Roden, Stephan G. Frangakis, Brett Vanderwerff, C. Michael Stein, Sara L. Van Driest, Scott C. Borinstein, Xiao-Ou Shu, Matthew Zawistowski, Cecilia P. Chung, Vivian K. Kawai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical consequences of a genetic predisposit
Externí odkaz:
https://doaj.org/article/aac9cb1b2aa64c909fbdd66e307ed326
Autor:
Yu Deng, Jennifer A. Pacheco, Anika Ghosh, Anh Chung, Chengsheng Mao, Joshua C. Smith, Juan Zhao, Wei-Qi Wei, April Barnado, Chad Dorn, Chunhua Weng, Cong Liu, Adam Cordon, Jingzhi Yu, Yacob Tedla, Abel Kho, Rosalind Ramsey-Goldman, Theresa Walunas, Yuan Luo
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 22, Iss S2, Pp 1-11 (2024)
Abstract Background Systemic lupus erythematosus (SLE) is a rare autoimmune disorder characterized by an unpredictable course of flares and remission with diverse manifestations. Lupus nephritis, one of the major disease manifestations of SLE for org
Externí odkaz:
https://doaj.org/article/427993f2ebd84e34b2219fd539d26f42
Autor:
Lan Jiang, Srushti Gangireddy, Alyson L. Dickson, Yi Xin, Chao Yan, Vivian Kawai, Nancy J. Cox, MacRae F. Linton, Wei-Qi Wei, C. Michael Stein, QiPing Feng
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100569- (2024)
Hypertriglyceridemia (HTG) is a common cardiovascular risk factor characterized by elevated triglyceride (TG) levels. Researchers have assessed the genetic factors that influence HTG in studies focused predominantly on individuals of European ancestr
Externí odkaz:
https://doaj.org/article/da16de995003474fb80d5f0f18e3d4e6
Autor:
Chao Yan, Monika E. Grabowska, Alyson L. Dickson, Bingshan Li, Zhexing Wen, Dan M. Roden, C. Michael Stein, Peter J. Embí, Josh F. Peterson, QiPing Feng, Bradley A. Malin, Wei-Qi Wei
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-6 (2024)
Abstract Drug repurposing represents an attractive alternative to the costly and time-consuming process of new drug development, particularly for serious, widespread conditions with limited effective treatments, such as Alzheimer’s disease (AD). Em
Externí odkaz:
https://doaj.org/article/5a14ed00b9d54394bba0dc3ee3901fe9
Autor:
Yask Gupta, David J. Friedman, Michelle T. McNulty, Atlas Khan, Brandon Lane, Chen Wang, Juntao Ke, Gina Jin, Benjamin Wooden, Andrea L. Knob, Tze Y. Lim, Gerald B. Appel, Kinsie Huggins, Lili Liu, Adele Mitrotti, Megan C. Stangl, Andrew Bomback, Rik Westland, Monica Bodria, Maddalena Marasa, Ning Shang, David J. Cohen, Russell J. Crew, William Morello, Pietro Canetta, Jai Radhakrishnan, Jeremiah Martino, Qingxue Liu, Wendy K. Chung, Angelica Espinoza, Yuan Luo, Wei-Qi Wei, Qiping Feng, Chunhua Weng, Yilu Fang, Iftikhar J. Kullo, Mohammadreza Naderian, Nita Limdi, Marguerite R. Irvin, Hemant Tiwari, Sumit Mohan, Maya Rao, Geoffrey K. Dube, Ninad S. Chaudhary, Orlando M. Gutiérrez, Suzanne E. Judd, Mary Cushman, Leslie A. Lange, Ethan M. Lange, Daniel L. Bivona, Miguel Verbitsky, Cheryl A. Winkler, Jeffrey B. Kopp, Dominick Santoriello, Ibrahim Batal, Sérgio Veloso Brant Pinheiro, Eduardo Araújo Oliveira, Ana Cristina Simoes e Silva, Isabella Pisani, Enrico Fiaccadori, Fangming Lin, Loreto Gesualdo, Antonio Amoroso, Gian Marco Ghiggeri, Vivette D. D’Agati, Riccardo Magistroni, Eimear E. Kenny, Ruth J. F. Loos, Giovanni Montini, Friedhelm Hildebrandt, Dirk S. Paul, Slavé Petrovski, David B. Goldstein, Matthias Kretzler, Rasheed Gbadegesin, Ali G. Gharavi, Krzysztof Kiryluk, Matthew G. Sampson, Martin R. Pollak, Simone Sanna-Cherchi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Abstract African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play a major role in this di
Externí odkaz:
https://doaj.org/article/9f6233ad88a44f828fd1c0264b712139
Autor:
Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson, Wei-Qi Wei, Qiping Feng, Bahram Namjou, Krzysztof Kiryluk, Iftikhar J. Kullo, Yuan Luo, Blair D. Sullivan, Benjamin F. Voight, Carsten Skarke, Marylyn D. Ritchie, Struan F. A. Grant, eMERGE Consortium, Casey S. Greene
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Genes act in concert with each other in specific contexts to perform their functions. Determining how these genes influence complex traits requires a mechanistic understanding of expression regulation across different conditions. It has been
Externí odkaz:
https://doaj.org/article/9662721d345640b697319b4a25963163
Autor:
Jacy T. Zanussi, Juan Zhao, Wei-Qi Wei, Gul Karakoc, Cecilia P. Chung, QiPing Feng, Nancy J. Olsen, C. Michael Stein, Vivian K. Kawai
Publikováno v:
BMC Rheumatology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract Background Antinuclear antibodies (ANA) are antibodies present in several autoimmune disorders. However, a large proportion of the general population (20%) also have a positive test; very few of these individuals will develop an autoimmune d
Externí odkaz:
https://doaj.org/article/280a134e6c6c4265ac4f1fd6e3ad3683
Autor:
Ge Liu, Lan Jiang, V. Eric Kerchberger, Annette Oeser, Andrea Ihegword, Alyson L. Dickson, Laura L. Daniel, Christian Shaffer, MacRae F. Linton, Nancy Cox, Cecilia P. Chung, Wei‐Qi Wei, C. Michael Stein, QiPing Feng
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 489-501 (2023)
Abstract Sepsis accounts for one in three hospital deaths. Higher concentrations of high‐density lipoprotein cholesterol (HDL‐C) are associated with apparent protection from sepsis, suggesting a potential therapeutic role for HDL‐C or drugs, su
Externí odkaz:
https://doaj.org/article/f1784ad21d1243438fdafdbfcfef9f94
Autor:
Lan Jiang, Ge Liu, Annette Oeser, Andrea Ihegword, Alyson L Dickson, Laura L Daniel, Adriana M Hung, Nancy J Cox, Cecilia P Chung, Wei-Qi Wei, C Michael Stein, Qiping Feng
Publikováno v:
eLife, Vol 12 (2023)
Background: Two risk variants in the apolipoprotein L1 gene (APOL1) have been associated with increased susceptibility to sepsis in Black patients. However, it remains unclear whether APOL1 high-risk genotypes are associated with occurrence of either
Externí odkaz:
https://doaj.org/article/3baa0f4a81db461eb55066a00231d9f0
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Alzheimer’s disease (AD) is a debilitating neurodegenerative condition with few treatment options available. Drug repurposing studies have sought to identify existing drugs that could be repositioned to treat AD; however, the effectiven
Externí odkaz:
https://doaj.org/article/e6f8bd97e63a417784d8151b2d655526