Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Wei-Li Gong"'
Autor:
Chen Sun, Ning Li, Qian-Qian Wang, Lu-Yi Yan, Shuai-Kang Ba, Shan-Shan Zhang, Qiu-Xia He, Xi-Qiang Chen, Wei-Li Gong, Qing Zhu, Ke-Chun Liu
Publikováno v:
Physiological Genomics. 54:141-152
Sick sinus syndrome (SSS) is a term used for a variety of disorders defined by abnormal cardiac impulse formation and by abnormal propagation from the heart’s sinoatrial node. In this study, we present a case from a Chinese family in which two clos
Autor:
Yuan Chen, Shao-Xin Wang, Rui Mu, Xue Luo, Zhao-Shan Liu, Bing Liang, Hai-Long Zhuo, Xiao-Peng Hao, Qiong Wang, Di-Feng Fang, Zhao-Fang Bai, Qian-Yi Wang, He-Mei Wang, Bao-Feng Jin, Wei-Li Gong, Tao Zhou, Xue-Min Zhang, Qing Xia, Tao Li
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1982-1993 (2014)
CUEDC2, a CUE-domain-containing protein, modulates inflammation, but its involvement in tumorigenesis is still poorly understood. Here, we report that CUEDC2 is a key regulator of macrophage function and critical for protection against colitis-associ
Externí odkaz:
https://doaj.org/article/d462a85face44d2085ad889d45bf1a94
Autor:
Xin Pan, Tao Zhou, Xue-Min Zhang, Liang Chen, Wei-Na Zhang, Na Wang, Jin-Jing Xu, Jiang-Hong Man, Yan Chang, Hui-Yan Li, Bao-Feng Jin, Bing Liang, Wei-Li Gong, Tao Li, Jie Zhou, Li Wang, Wei-Hua Li, Rui Mu, Qing Xia, Ai-Ling Li
Publikováno v:
Proceedings of the National Academy of Sciences. 110:11017-11022
DNA damage triggers cell cycle arrest to provide a time window for DNA repair. Failure of arrest could lead to genomic instability and tumorigenesis. DNA damage-induced G 1 arrest is generally achieved by the accumulation of Cyclin-dependent kinase i
Autor:
Xin Pan, Tao Zhou, Hui-Yan Li, Qiong Wang, Bao-Feng Jin, Bing Liang, Wei-Li Gong, Tao Li, Ming Yu, Xue Luo, Yuan Chen, Wei-Na Zhang, Wei-Hua Li, Difeng Fang, Li Wang, Qing Xia, Ai-Ling Li, Jiang-Hong Man, Liang Chen
Publikováno v:
Journal of Biological Chemistry. 287:382-392
Janus kinase 1/signal transducers and activators of transcription 3 (JAK1/STAT3) pathway is one of the recognized oncogenic signaling pathways that frequently overactivated in a variety of human tumors. Despite rapid progress in elucidating the molec
Autor:
Cheng Zhen, Ming Yu, Yan Chang, Tao Li, Ai-Ling Li, Xue-Min Zhang, Yan-Fei Gao, Wei-Na Zhang, Kun He, Liang Chen, Yuan Chen, Wei-Hua Li, Teng Li, Jiang-Hong Man, Hui-Yan Li, Wei-Li Gong, Xin Pan, Tao Zhou, Yu-Bo Wang, Qing Xia, Rui Mu, Bing Liang
Publikováno v:
Nature Cell Biology. 13:924-933
Aneuploidy and chromosomal instability are major characteristics of human cancer. These abnormalities can result from defects in the spindle assembly checkpoint (SAC), which is a surveillance mechanism for accurate chromosome segregation through rest
Autor:
Bing Liang, Xin Pan, Cheng Zhen, Zhao Jian, Wei-Li Gong, Hui Yan Li, Li Xin Wei, Yan Hong Tai, Jie Zhao, Yuan Chen, Xue-Min Zhang, Jiang Hong Man, Rui Mu, Zhao Fang Bai, Ai-Ling Li, Tao Zhou, Chenguang Wang, Yan Fei Gao, Yuan Cao, Peijing Zhang, Wei-Na Zhang, Ming Yu
Publikováno v:
Nature Medicine. 17:708-714
Endocrine resistance is a major obstacle to hormonal therapy for breast cancers. Although reduced expression of estrogen receptor-α (ER-α) is a known contributing factor to endocrine resistance, the mechanism of ER-α downregulation in endocrine re
Autor:
Bing Liang, Bing Bai, Tao Zhou, Wei-Na Zhang, Hai Ying Zhang, Yuexi Gu, Tao Li, Bao Feng Jin, Wei-Hua Li, Hui Yan Li, Wei-Li Gong, Ai-Ling Li, Xue-Min Zhang, Jiang Hong Man
Publikováno v:
Journal of Clinical Investigation. 120:2829-2841
Activating mutations in Ras proteins are present in about 30% of human cancers. Despite tremendous progress in the study of Ras oncogenes, many aspects of the molecular mechanisms underlying Ras-induced tumorigenesis remain unknown. Through proteomic
Physical modeling of failure process of the excavation in horizontal strata based on IR thermography
Publikováno v:
Mining Science and Technology (China). 19:689-698
In order to capture the mechanism of roadway instability in deep mines, a new approach of Physically Finite Elemental Slab Assemblage (PFESA) is proposed in order to construct a large-scale physical model simulating the geologically horizontal strata
Autor:
Hongxia Wang, Song-Cheng Yang, Yan Li, Tao Zhou, Ailing Li, Xuemin Zhang, Tao Li, Xin-Yu Wen, Kun He, Wei-Li Gong, Wei-Hua Li, Na Wang, YaPing Tian, Jie Wang
Publikováno v:
Science Bulletin. 54:421-429
Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS)–based signatures as biomarkers, we investigated bre
Autor:
Xin Pan, Lifeng Tian, Bao Feng Jin, Peijing Zhang, Wei-Hua Li, Chenhui Wang, Bing Liang, Tao Li, Gui Ying Su, Kun He, Zhi Yi Zhang, Ai-Ling Li, Wei-Li Gong, Tao Zhou, Xue-Min Zhang, Hui Liu, Jiang Hong Man, Jie Zhao, Hui Yan Li
Publikováno v:
Journal of Proteome Research. 6:4397-4406
A global understanding of ubiquitinated proteins in vivo is key to unraveling the biological significance of ubiquitination. There are, however, a few effective screening methods for rapid analysis of ubiquitinated proteins. In the current study, we