Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Wei-Li Di"'
Autor:
Alice Burleigh, Elena Moraitis, Eman Al Masroori, Eslam Al-Abadi, Ying Hong, Ebun Omoyinmi, Hannah Titheradge, Karen Stals, Wendy D. Jones, Anthony Gait, Vignesh Jayarajan, Wei-Li Di, Neil Sebire, Lea Solman, Malobi Ogboli, Steven B. Welch, Annapurna Sudarsanam, Ian Wacogne, Fiona Price-Kuehne, Barbara Jensen, Paul A. Brogan, Despina Eleftheriou
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ISG15 deficiency is a rare disease caused by autosomal recessive variants in the ISG15 gene, which encodes the ISG15 protein. The ISG15 protein plays a dual role in both the type I and II interferon (IFN) immune pathways. Extracellularly, the ISG15 p
Externí odkaz:
https://doaj.org/article/c36d89f5574143d294b7edb06389dfd6
Autor:
Gaetano Naso, Soragia Athina Gkazi, Christos Georgiadis, Vignesh Jayarajan, Joanna Jacków, Roland Fleck, Leanne Allison, Olumide Kayode Ogunbiyi, John Alexander McGrath, Dusko Ilic, Wei-Li Di, Anastasia Petrova, Waseem Qasim
Publikováno v:
JID Innovations, Vol 3, Iss 3, Pp 100191- (2023)
Recessive dystrophic epidermolysis bullosa is a debilitating blistering skin disorder caused by loss-of-function mutations in COL7A1, which encodes type VII collagen, the main component of anchoring fibrils at the dermal−epidermal junction. Althoug
Externí odkaz:
https://doaj.org/article/9263ccbe4af242a788d4bbea877e0263
Autor:
Victoria Gálvez, Esteban Chacón-Solano, Jose Bonafont, Ángeles Mencía, Wei-Li Di, Rodolfo Murillas, Sara Llames, Asunción Vicente, Marcela Del Rio, Marta Carretero, Fernando Larcher
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 280-290 (2020)
Current efforts to find specific genodermatoses treatments and define precise pathogenesis mechanisms require appropriate surrogate models with human cells. Although transgenic and gene knockout mouse models for several of these disorders exist, they
Externí odkaz:
https://doaj.org/article/d75b071d40cb45b5b8edf78f7f767001
Autor:
Vignesh Jayarajan, George T. Hall, Theodoros Xenakis, Neil Bulstrode, Dale Moulding, Sergi Castellano, Wei-Li Di
Publikováno v:
Cells, Vol 12, Iss 3, p 346 (2023)
Primary keratinocytes including keratinocyte stem cells (KSCs) can be cultured as epidermal sheets in vitro and are attractive for cell and gene therapies for genetic skin disorders. However, the initial slow growth of freshly isolated keratinocytes
Externí odkaz:
https://doaj.org/article/0305322fe49c4ab8a545bf67ed65af03
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166268 (2016)
Tissue kallikreins (KLKs), in particular KLK5, 7 and 14 are the major serine proteases in the skin responsible for skin shedding and activation of inflammatory cell signaling. In the normal skin, their activities are controlled by an endogenous prote
Externí odkaz:
https://doaj.org/article/41b6d02ba7dd4ecbb081e4896f766707
Autor:
Burleigh, Alice, Moraitis, Elena, Al Masroori, Eman, Al-Abadi, Eslam, Ying Hong, Ebun Omoyinmi, Titheradge, Hannah, Stals, Karen, Jones, Wendy D., Gait, Anthony, Jayarajan, Vignesh, Wei-Li Di, Sebire, Neil, Solman, Lea, Ogboli, Malobi, Welch, Steven B., Sudarsanam, Annapurna, Wacogne, Ian, Price-Kuehne, Fiona, Jensen, Barbara
Publikováno v:
Frontiers in Immunology; 2023, p1-11, 11p
Autor:
James McRae, WEi-Li DI, Patricia Barral, Enrica Calvani, Peter Clayton, Philippa Mills, Youssef Khalil, Olumide Ogunbiyi, Nicole Knoepfel, Alicia L. Bruzos, Paulina Stadnik., Connor Hughes, Veronica Kinsler, James ellis, Aimie Sauvadet, Satyamaanasa Polubothu, Melissa Riachi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1a9a90dfb17302a27ce662d86c4a0aa
https://doi.org/10.26226/m.62fa0098ba67fd001a9a0923
https://doi.org/10.26226/m.62fa0098ba67fd001a9a0923
Autor:
Vignesh Jayarajan, George T. Hall, Theodoros Xenakis, Neil Bulstrode, Dale Moulding, Sergi Castellano, Wei-Li Di
Somatic stem cells can be cultured in-vitro and are attractive for cell and gene therapies, but their slow growth in in-vitro culture affects survival and stemness and hinders clinical applications. Rho-associated kinase inhibitor (ROCKi) has been us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::995341024f54d6136e04736f21232ce3
https://doi.org/10.1101/2022.06.28.497914
https://doi.org/10.1101/2022.06.28.497914
Publikováno v:
Experimental Dermatology
Genetic skin diseases, also known as genodermatoses, are inherited disorders affecting skin and constitute a large and heterogeneous group of diseases. While genodermatoses are rare with the prevalence rate of less than 1 in 50,000 – 200,000, they