Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Wei-Lan Yeh"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Pulmonary fibrosis features in damaged pulmonary structure or over-produced extracellular matrix and impaired lung function, leading to respiratory failure and eventually death. Fibrotic lungs are characterized by the secretion of pro-fib
Externí odkaz:
https://doaj.org/article/bb17719baa3247afb27b3a7064ae15e3
Autor:
Yen-Chang Chen, Chen-Teng Wu, Jia-Hong Chen, Cheng-Fang Tsai, Chen-Yun Wu, Pei-Chun Chang, Wei-Lan Yeh
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-9 (2022)
Abstract Migration and metastasis commonly happen to triple-negative breast cancer (TNBC) patients with advanced diseases. In many studies, it has been suggested that epithelial-mesenchymal transition (EMT) is one of the key mechanisms triggering can
Externí odkaz:
https://doaj.org/article/76922b2bdf0b42238f90a7e4f591f3c7
Autor:
Ching-Kai Shen, Bor-Ren Huang, Vichuda Charoensaensuk, Liang-Yo Yang, Cheng-Fang Tsai, Yu-Shu Liu, Dah-Yuu Lu, Wei-Lan Yeh, Chingju Lin
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1533 (2023)
Bradykinin is a small active peptide and is considered an inflammatory mediator in several pathological conditions. Bradykinin exerts its effects by coupling to its receptors, including bradykinin B1 (B1R) and bradykinin B2. B1R has been implicated i
Externí odkaz:
https://doaj.org/article/a9c0c824964145faa5200fd73dfc87c8
Autor:
Yen-Chang Chen, Jia-Hong Chen, Cheng-Fang Tsai, Chen-Teng Wu, Miao-Hsiang Wu, Pei-Chun Chang, Wei-Lan Yeh
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Metastasis represents an advanced stage of cancers, and matrix metalloproteinases are critical regulators. Calcium signal is crucial for appropriate cell behaviors. The efficacy and effects of calcium channel blockers in treating cancers
Externí odkaz:
https://doaj.org/article/7c917c12d8894107925d37d57de352f0
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-12 (2017)
Abstract Background Mesenchymal stem cells in tumor microenvironment can influence therapeutic responses in various types of cancers. For triple negative breast cancer, chemotherapy remains the mainstay of standard treatment. Our aim was to investiga
Externí odkaz:
https://doaj.org/article/fa271110590a40a7875b302dfb05c2bb
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 11 (2019)
Background: Leptin is considered a tumorigenic adipokine, suggested to promote tumorigenesis and progression in many cancers. On the other hand, intercellular adhesion molecule-1 (ICAM-1) shows altered expression in a variety of benign and malignant
Externí odkaz:
https://doaj.org/article/55ea5fb51ef747d38c820922b8685faa
Autor:
Jing-Yuan Chuang, Pei-Chun Chang, Yi-Chun Shen, Chingju Lin, Cheng-Fang Tsai, Jia-Hong Chen, Wei-Lan Yeh, Ling-Hsuan Wu, Hsiao-Yun Lin, Yu-Shu Liu, Dah-Yuu Lu
Publikováno v:
Molecules, Vol 19, Iss 7, Pp 8820-8839 (2014)
Increasing evidence suggests that inflammatory processes in the central nervous system that are mediated by microglial activation play a key role in neurodegeneration. Fisetin, a plant flavonol commonly found in fruits and vegetables, is frequently a
Externí odkaz:
https://doaj.org/article/90953cdb9cfc4abdbf4469228ac6d5a6
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98805 (2014)
Tamoxifen has long been used and still is the most commonly used endocrine therapy for treatment of both early and advanced estrogen receptor-positive breast cancer in pre- and post-menopause women. Tamoxifen exerts its cytotoxic effect primarily thr
Externí odkaz:
https://doaj.org/article/34c75769992945b38a66644ca816fce3
Autor:
Bor-Ren Huang, Pei-Chun Chang, Wei-Lan Yeh, Chih-Hao Lee, Cheng-Fang Tsai, Chingju Lin, Hsiao-Yun Lin, Yu-Shu Liu, Caren Yu-Ju Wu, Pei-Ying Ko, Shiang-Suo Huang, Horng-Chaung Hsu, Dah-Yuu Lu
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91167 (2014)
BACKGROUND/OBJECTIVE: Nicardipine is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. However, accumul
Externí odkaz:
https://doaj.org/article/a45df5fc97e34a55baaae644529a2ec8
Autor:
Wei-Lan Yeh, Keiko Shioda, Kathryn R Coser, Danielle Rivizzigno, Kristen R McSweeney, Toshi Shioda
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60889 (2013)
Fulvestrant is a representative pure antiestrogen and a Selective Estrogen Receptor Down-regulator (SERD). In contrast to the Selective Estrogen Receptor Modulators (SERMs) such as 4-hydroxytamoxifen that bind to estrogen receptor α (ERα) as antago
Externí odkaz:
https://doaj.org/article/e4297ff6838e47be81ffa339fb958acd