Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Wei-Jen Tang"'
Autor:
Wenguang G. Liang, Juwina Wijaya, Hui Wei, Alex J. Noble, Jordan M. Mancl, Swansea Mo, David Lee, John V. Lin King, Man Pan, Chang Liu, Carla M. Koehler, Minglei Zhao, Clinton S. Potter, Bridget Carragher, Sheng Li, Wei-Jen Tang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Presequence protease (PreP) is essential to mitochondrial proteostasis. This study leverages advanced vitrification techniques to solve cryoEM structures of apo- and substrate-bound PreP and integrates these data with other analysis to reveal key sta
Externí odkaz:
https://doaj.org/article/d99e3402e9504dfda0d7d987246a3e86
Autor:
Yanlei Ma, Jiping Yue, Yao Zhang, Chenzhang Shi, Matt Odenwald, Wenguang G. Liang, Qing Wei, Ajay Goel, Xuewen Gou, Jamie Zhang, Shao-Yu Chen, Wei-Jen Tang, Jerrold R. Turner, Feng Yang, Hong Liang, Huanlong Qin, Xiaoyang Wu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The cytoskeleton plays a key role in cell/cell junction formation, but how the coordinated behaviour of the cytoskeleton contributes is not known. Here the authors show that actin-microtubule crosslinker ACF7 plays a key role in tight junction stabil
Externí odkaz:
https://doaj.org/article/c8c2b37e2d3f4afba906bc428a635587
Autor:
Jiping Yue, Yao Zhang, Wenguang G. Liang, Xuewen Gou, Philbert Lee, Han Liu, Wanqing Lyu, Wei-Jen Tang, Shao-Yu Chen, Feng Yang, Hong Liang, Xiaoyang Wu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
The spectraplakin protein ACF7 binds to actin at focal adhesions and targets microtubule plus ends to focal adhesions, promoting their disassembly. Here the authors reveal that ACF7 is phosphorylated by Src/FAK, and this regulates actin binding and f
Externí odkaz:
https://doaj.org/article/f1b9a1f82978443286b0a25d4146f0c2
Autor:
Zhening Zhang, Wenguang G Liang, Lucas J Bailey, Yong Zi Tan, Hui Wei, Andrew Wang, Mara Farcasanu, Virgil A Woods, Lauren A McCord, David Lee, Weifeng Shang, Rebecca Deprez-Poulain, Benoit Deprez, David R Liu, Akiko Koide, Shohei Koide, Anthony A Kossiakoff, Sheng Li, Bridget Carragher, Clinton S Potter, Wei-Jen Tang
Publikováno v:
eLife, Vol 7 (2018)
Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two diabetes, Alzheimer's, inflammation, and other human diseases. However, the process through which IDE recognizes peptides that tend to form amyloid fibrils remaine
Externí odkaz:
https://doaj.org/article/bdf640b40b944a06bfcc72ce62dd4071
Autor:
Carolin Lübker, Stefan Dove, Wei-Jen Tang, Ramona J. Bieber Urbauer, Jackob Moskovitz, Jeffrey L. Urbauer, Roland Seifert
Publikováno v:
Toxins, Vol 7, Iss 7, Pp 2598-2614 (2015)
Bacillus anthracis adenylyl cyclase toxin edema factor (EF) is one component of the anthrax toxin and is essential for establishing anthrax disease. EF activation by the eukaryotic Ca2+-sensor calmodulin (CaM) leads to massive cAMP production resulti
Externí odkaz:
https://doaj.org/article/87b673535fe9474895c77e625b6c22bc
Autor:
Yanlei Ma, Jiping Yue, Yao Zhang, Chenzhang Shi, Matt Odenwald, Wenguang G. Liang, Qing Wei, Ajay Goel, Xuewen Gou, Jamie Zhang, Shao-Yu Chen, Wei-Jen Tang, Jerrold R. Turner, Feng Yang, Hong Liang, Huanlong Qin, Xiaoyang Wu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number: 15375 (2017); Published: 25 May 2017; Updated: 11 July 2017 The affiliation details for Yanlei Ma and Yao Zhang are incorrect in this Article. The correct affiliation details for these authors are given below:
Externí odkaz:
https://doaj.org/article/d92fec498395400fb41e75a72d04206d
Autor:
Kerstin Y Beste, Corinna M Spangler, Heike Burhenne, Karl-Wilhelm Koch, Yuequan Shen, Wei-Jen Tang, Volkhard Kaever, Roland Seifert
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70223 (2013)
Guanylyl cyclases (GCs) regulate many physiological processes by catalyzing the synthesis of the second messenger cGMP. The GC family consists of seven particulate GCs (pGCs) and a nitric oxide-activated soluble GC (sGC). Rat sGC α1β1 possesses muc
Externí odkaz:
https://doaj.org/article/40961eb1374742daac06bf24d9c7677e
Autor:
Malcolm A Leissring, Enrico Malito, Sabrine Hedouin, Lael Reinstatler, Tomoko Sahara, Samer O Abdul-Hay, Shakeel Choudhry, Ghulam M Maharvi, Abdul H Fauq, Malwina Huzarska, Philip S May, Sungwoon Choi, Todd P Logan, Benjamin E Turk, Lewis C Cantley, Marika Manolopoulou, Wei-Jen Tang, Ross L Stein, Gregory D Cuny, Dennis J Selkoe
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10504 (2010)
Insulin is a vital peptide hormone that is a central regulator of glucose homeostasis, and impairments in insulin signaling cause diabetes mellitus. In principle, it should be possible to enhance the activity of insulin by inhibiting its catabolism,
Externí odkaz:
https://doaj.org/article/7240b4ca7af64bf1b6cd154a5b3c1c60
Autor:
Linley E Watson, Shu-Ru Kuo, Khurshed Katki, Tongyun Dang, Seong Kyu Park, David E Dostal, Wei-Jen Tang, Stephen H Leppla, Arthur E Frankel
Publikováno v:
PLoS ONE, Vol 2, Iss 5, p e466 (2007)
Anthrax infections are frequently associated with severe and often irreversible hypotensive shock. The isolated toxic proteins of Bacillus anthracis produce a non-cytokine-mediated hypotension in rats by unknown mechanisms. These observations suggest
Externí odkaz:
https://doaj.org/article/5852b824721a42d18655ae1e0f2fc452
Publikováno v:
J Biol Chem
Pseudomonas aeruginosa uses a type III secretion system (T3SS) to inject cytotoxic effector proteins into host cells. The promiscuous nucleotidyl cyclase, exoenzyme Y (ExoY), is one of the most common effectors found in clinical P. aeruginosa isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61d8cb287e341a108f61679b3838098
https://doi.org/10.1074/jbc.ra119.012320
https://doi.org/10.1074/jbc.ra119.012320