Distinct and heterogeneous trajectories of self-perceived cognitive impairment among Asian breast cancer survivors

Autor: Alexandre Chan, Hui Ling Yeo, Wei-Jen Kiley Loh, Yan Xiang Gan, Sreemanee Raaj Dorajoo, Yoon Sim Yap, Maung Shwe, Amit Jain, Guek Eng Lee, Yin Ting Cheung, Raymond Ng, Koon Mian Foo, Yick Ching Lam, Si-Lin Koo, Rebecca Dent, Terence Ng

Publikováno v: Psycho-Oncology. 27:1185-1192

OBJECTIVES Currently, there are no studies that have established the self-perceived cognitive trajectories experienced by breast cancer patients (BCPs) post-chemotherapy. Therefore, we characterized the long-term trajectory of self-perceived cognitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ab79feff724db0cae4f8d946b8664b
https://doi.org/10.1002/pon.4635

Brain-derived neurotrophic factor genetic polymorphism (rs6265) is protective against chemotherapy-associated cognitive impairment in patients with early-stage breast cancer

Autor: Terence Ng, Maung Shwe, Wei-Jen Kiley Loh, Yin Ting Cheung, Si-Lin Koo, Alexandre Chan, Rebecca Dent, Mabel Wong, Koon Mian Foo, Hui Ling Yeo, Gilbert Fan, Wei Sean Yong, Guek Eng Lee, Raymond Ng, Yoon Sim Yap, Chiea Chuen Khor, Han Kiat Ho, Jung Ah Lee, Yan Xiang Gan, Madhukumar Preetha, Amit Jain, Shu Mei Teo, Yee Pin Tan, Mooi Tai Cham

Publikováno v: Neuro-Oncology

Background Brain-derived neurotrophic factor (BDNF), a neurotrophin that regulates neuronal function and development, is implicated in several neurodegenerative conditions. Preliminary data suggest that a reduction of BDNF concentrations may lead to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e12b4aefdb718b9376e712c6ce5c7a
https://pubmed.ncbi.nlm.nih.gov/26289590

A genome-wide association study (GWAS) meta-analysis of chemotherapy-associated cognitive impairment (CACI) in Asian early-stage breast cancer patients (ESBC)

Autor: Rebecca Dent, Terence Ng, Hsuen Elaine Lim, Chiea Chuen Khor, Wei-Jen Kiley Loh, Pak Yan Pat Chu, Yoon Sim Yap, Guek Eng Lee, Tira Jing Ying Tan, Koon Mian Foo, Maung Shwe, Si-Lin Koo, Alexandre Chan, Wen Yee Chay, Raymond Ng, Han Kiat Ho, Sok Yuen Beh, Hui Ling Angie Yeo, Yan Xiang Gan

Publikováno v: Journal of Clinical Oncology. 35:10096-10096

10096 Background: Genetic variations among genes regulating neuronal function, neurotransmission and plasticity may contribute to varying risk of CACI. In order to fully elucidate the complex genetic structure underlying CACI, a GWAS meta-analysis wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::324bbcf84adb666fe2847930128c23cb
https://doi.org/10.1200/jco.2017.35.15_suppl.10096

DNA methyltransferase 1 (DNMT1) polymorphism and chemotherapy-associated cognitive impairment in early-stage breast cancer patients (ESBC): A prospective, longitudinal study

Autor: Hui Ling Angie Yeo, Han Kiat Ho, Yan Xiang Gan, Wei-Jen Kiley Loh, Rebecca Dent, Mooi Tai Cham, Terence Ng, Pak Yan Pa Chu, Yoon Sim Yap, Raymond Ng, Jung Ah Lee, Amit Jain, Maung Shwe, Si-Lin Koo, Guek Eng Lee, Alexandre Chan, Ming Tjong Chian, Chiea Chuen Khor

Publikováno v: Journal of Clinical Oncology. 34:10014-10014

10014Background: Epigenetic regulation via methylation plays a crucial role for the functioning and survival of neuronal cells. DNA methyltransferase 1 (DNMT1) is an enzyme to maintain methylation ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6a033f5466a209be374c0f13be5feca
https://doi.org/10.1200/jco.2016.34.15_suppl.10014

Cancer Supportive and Survivorship Care in Singapore: Current Challenges and Future Outlook.

Autor: Loh KW; Wei-Jen Kiley Loh, Terence Ng, Su Pin Choo, Alethea Chung Pheng Yee, Alexandre Chan, and Khee Chee Soo, National Cancer Centre Singapore; Hay Mar Saw, Singapore General Hospital; Rathi Mahendran, National University Hospital; Celia Tan, Allied Health, Singhealth Services; Gail Chia Yang Chang, KK Women's and Children's Hospital; Yew Jin Ong, Singapore Cancer Society; and Alexandre Chan, National University of Singapore (NUS) and Duke-NUS Graduate Medical School, Singapore., Ng T; Wei-Jen Kiley Loh, Terence Ng, Su Pin Choo, Alethea Chung Pheng Yee, Alexandre Chan, and Khee Chee Soo, National Cancer Centre Singapore; Hay Mar Saw, Singapore General Hospital; Rathi Mahendran, National University Hospital; Celia Tan, Allied Health, Singhealth Services; Gail Chia Yang Chang, KK Women's and Children's Hospital; Yew Jin Ong, Singapore Cancer Society; and Alexandre Chan, National University of Singapore (NUS) and Duke-NUS Graduate Medical School, Singapore., Choo SP; Wei-Jen Kiley Loh, Terence Ng, Su Pin Choo, Alethea Chung Pheng Yee, Alexandre Chan, and Khee Chee Soo, National Cancer Centre Singapore; Hay Mar Saw, Singapore General Hospital; Rathi Mahendran, National University Hospital; Celia Tan, Allied Health, Singhealth Services; Gail Chia Yang Chang, KK Women's and Children's Hospital; Yew Jin Ong, Singapore Cancer Society; and Alexandre Chan, National University of Singapore (NUS) and Duke-NUS Graduate Medical School, Singapore., Saw HM; Wei-Jen Kiley Loh, Terence Ng, Su Pin Choo, Alethea Chung Pheng Yee, Alexandre Chan, and Khee Chee Soo, National Cancer Centre Singapore; Hay Mar Saw, Singapore General Hospital; Rathi Mahendran, National University Hospital; Celia Tan, Allied Health, Singhealth Services; Gail Chia Yang Chang, KK Women's and Children's Hospital; Yew Jin Ong, Singapore Cancer Society; and Alexandre Chan, National University of Singapore (NUS) and Duke-NUS Graduate Medical School, Singapore., Mahendran R; Wei-Jen Kiley Loh, Terence Ng, Su Pin Choo, Alethea Chung Pheng Yee, Alexandre Chan, and Khee Chee Soo, National Cancer Centre Singapore; Hay Mar Saw, Singapore General Hospital; Rathi Mahendran, National University Hospital; Celia Tan, Allied Health, Singhealth Services; Gail Chia Yang Chang, KK Women's and Children's Hospital; Yew Jin Ong, Singapore Cancer Society; and Alexandre Chan, National University of Singapore (NUS) and Duke-NUS Graduate Medical School, Singapore., Tan C; Wei-Jen Kiley Loh, Terence Ng, Su Pin Choo, Alethea Chung Pheng Yee, Alexandre Chan, and Khee Chee Soo, National Cancer Centre Singapore; Hay Mar Saw, Singapore General Hospital; Rathi Mahendran, National University Hospital; Celia Tan, Allied Health, Singhealth Services; Gail Chia Yang Chang, KK Women's and Children's Hospital; Yew Jin Ong, Singapore Cancer Society; and Alexandre Chan, National University of Singapore (NUS) and Duke-NUS Graduate Medical School, Singapore., Chang GCY; Wei-Jen Kiley Loh, Terence Ng, Su Pin Choo, Alethea Chung Pheng Yee, Alexandre Chan, and Khee Chee Soo, National Cancer Centre Singapore; Hay Mar Saw, Singapore General Hospital; Rathi Mahendran, National University Hospital; Celia Tan, Allied Health, Singhealth Services; Gail Chia Yang Chang, KK Women's and Children's Hospital; Yew Jin Ong, Singapore Cancer Society; and Alexandre Chan, National University of Singapore (NUS) and Duke-NUS Graduate Medical School, Singapore., Ong YJ; Wei-Jen Kiley Loh, Terence Ng, Su Pin Choo, Alethea Chung Pheng Yee, Alexandre Chan, and Khee Chee Soo, National Cancer Centre Singapore; Hay Mar Saw, Singapore General Hospital; Rathi Mahendran, National University Hospital; Celia Tan, Allied Health, Singhealth Services; Gail Chia Yang Chang, KK Women's and Children's Hospital; Yew Jin Ong, Singapore Cancer Society; and Alexandre Chan, National University of Singapore (NUS) and Duke-NUS Graduate Medical School, Singapore., Yee ACP; Wei-Jen Kiley Loh, Terence Ng, Su Pin Choo, Alethea Chung Pheng Yee, Alexandre Chan, and Khee Chee Soo, National Cancer Centre Singapore; Hay Mar Saw, Singapore General Hospital; Rathi Mahendran, National University Hospital; Celia Tan, Allied Health, Singhealth Services; Gail Chia Yang Chang, KK Women's and Children's Hospital; Yew Jin Ong, Singapore Cancer Society; and Alexandre Chan, National University of Singapore (NUS) and Duke-NUS Graduate Medical School, Singapore., Chan A; Wei-Jen Kiley Loh, Terence Ng, Su Pin Choo, Alethea Chung Pheng Yee, Alexandre Chan, and Khee Chee Soo, National Cancer Centre Singapore; Hay Mar Saw, Singapore General Hospital; Rathi Mahendran, National University Hospital; Celia Tan, Allied Health, Singhealth Services; Gail Chia Yang Chang, KK Women's and Children's Hospital; Yew Jin Ong, Singapore Cancer Society; and Alexandre Chan, National University of Singapore (NUS) and Duke-NUS Graduate Medical School, Singapore., Soo KC; Wei-Jen Kiley Loh, Terence Ng, Su Pin Choo, Alethea Chung Pheng Yee, Alexandre Chan, and Khee Chee Soo, National Cancer Centre Singapore; Hay Mar Saw, Singapore General Hospital; Rathi Mahendran, National University Hospital; Celia Tan, Allied Health, Singhealth Services; Gail Chia Yang Chang, KK Women's and Children's Hospital; Yew Jin Ong, Singapore Cancer Society; and Alexandre Chan, National University of Singapore (NUS) and Duke-NUS Graduate Medical School, Singapore.

Publikováno v: Journal of global oncology [J Glob Oncol] 2018 Sep; Vol. 4, pp. 1-8.