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Bis(chloroacetamidino)-Derived Heteroarene-Fused Anthraquinones Bind to and Cause Proteasomal Degradation of tNOX, Leading to c-Flip Downregulation and Apoptosis in Oral Cancer Cells

Autor: Jeng Shiun Chang, Chien-Yu Chen, Alexander S. Tikhomirov, Atikul Islam, Ru-Hao Liang, Chia-Wei Weng, Wei-Hou Wu, Andrey E. Shchekotikhin, Pin Ju Chueh

Publikováno v: Cancers; Volume 14; Issue 19; Pages: 4719

Anthraquinone-based intercalating compounds, namely doxorubicin and mitoxantrone, have been used clinically based on their capacity to bind DNA and induce DNA damage. However, their applications have been limited by side effects and drug resistance.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d972b906e636533af406900cac6baf

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Capsaicin attenuates cell migration via SIRT1 targeting and inhibition to enhance cortactin and β-catenin acetylation in bladder cancer cells

Autor: Atikul, Islam, Ya-Ting, Yang, Wei-Hou, Wu, Pin Ju, Chueh, Ming-Hung, Lin

Publikováno v: American journal of cancer research. 9(6)

We have studied the chemopreventive property of capsaicin, a major active component in chili pepper, and found that it exhibited apoptotic activity against various lines of cancer cells. Interestingly, accumulating data has revealed that, in addition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0783bc96534d73732a454a4d50b6331d
https://pubmed.ncbi.nlm.nih.gov/31285950

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