Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Wei-Guang Seetoh"'
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Akademický článek
Construction of a bioluminescence-based assay for bitter taste receptors (TAS2Rs)
Autor: Shi Min Tan, Wei-Guang Seetoh
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract In humans, a family of 25 bitter taste receptors (TAS2Rs) mediates bitter taste perception. A common approach to characterize bitter causative agents involves expressing TAS2Rs and the appropriate signal transducers in heterologous cell syst
Externí odkaz: https://doaj.org/article/e801c1735ea542879b6a0fb52146c11f
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2
Evaluation of anti-proliferative activity of medicinal plants used in Asian Traditional Medicine to treat cancer
Autor: Yew Hc, Tan Ch, Seow Sv, Hwee-Ling Koh, Lim Sw, Lim Cse, Ng Yc, Wei-Guang Seetoh, Yin-Yin Siew, Azhar Ali, Lew Sm, Soek-Ying Neo
Publikováno v: Journal of Ethnopharmacology. 235:75-87
Ethnopharmacological relevance The extensive biodiversity of plants in Southeast Asia and inadequate research hitherto warrant a continued investigation into medicinal plants. On the basis of a careful review of fresh medicinal plant usage to treat c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7537e033b21a9c72c6ca06ff7b0827d3
https://doi.org/10.1016/j.jep.2018.12.040
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3
2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 1: Identification of an allosteric binding site
Autor: Isabelle Krimm, Claude Cochet, Irina Kufareva, Ahmed A. M. Kamal, Thierry Lomberget, Benoit Bestgen, Rolf W. Hartmann, Ruben Abagyan, Matthias Engel, Wei-Guang Seetoh, Chris Abell, Marc Le Borgne
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (4), pp.1803-1816. ⟨10.1021/acs.jmedchem.8b01766⟩
Journal of Medicinal Chemistry, 2019, 62 (4), pp.1803-1816. ⟨10.1021/acs.jmedchem.8b01766⟩
J Med Chem
CK2 is a ubiquitous Ser/Thr protein kinase involved in the control of various signaling pathways and is known to be constitutively active. In the present study, we identified aryl 2-aminothiazoles as a novel class of CK2 inhibitors, which displayed a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066beaa02f97df972d46a5674a216934
https://hal.archives-ouvertes.fr/hal-02004986
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4
2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action
Autor: Thierry Lomberget, Odile Filhol, Claude Cochet, Rolf W. Hartmann, Irina Kufareva, Ruben Abagyan, Matthias Engel, Chris Abell, Wei-Guang Seetoh, Marc Le Borgne, Benoit Bestgen
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2019, 62 (4), pp.1817-1836. ⟨10.1021/acs.jmedchem.8b01765⟩
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (4), pp.1817-1836. ⟨10.1021/acs.jmedchem.8b01765⟩
Journal of medicinal chemistry, vol 62, iss 4
J Med Chem
Journal of medicinal chemistry
Protein CK2 has gained much interest as an anti-cancer drug target in the last decade. We had previously described the identification of a new allosteric site on the catalytic α-subunit, along with first small molecule ligands based on the 4-(4-phen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972ee90c1d86000f40814974dbe497ca
https://hal.science/hal-02465880
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5
Oxaliplatin regulates expression of stress ligands in ovarian cancer cells and modulates their susceptibility to natural killer cell-mediated cytotoxicity
Autor: See-Voon Seow, Yi-Cheng Ng, Hwee-Ling Koh, Yin-Yin Siew, Soek-Ying Neo, Si-Min Lew, Shun-Wei Lim, Hui-Chuing Yew, Wei-Guang Seetoh
Publikováno v: International Immunology. 27:621-632
Selected cytotoxic chemicals can provoke the immune system to recognize and destroy malignant tumors. Most of the studies on immunogenic cell death are focused on the signals that operate on a series of receptors expressed by dendritic cells to induc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93de9ad3c8472e8751d6ca4724a7e3e
https://doi.org/10.1093/intimm/dxv041
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6
Ethnobotanical survey of usage of fresh medicinal plants in Singapore
Autor: Soek-Ying Neo, Sogand Zareisedehizadeh, Wei-Guang Seetoh, Yin-Yin Siew, Chay Hoon Tan, Hwee-Ling Koh
Publikováno v: Journal of Ethnopharmacology. 155:1450-1466
Ethnopharmacological relevance The use of medicinal plants in human health has been documented since ancient times and they provide a useful source of new therapeutics. In Singapore, despite the accessibility to modern healthcare, there still exist p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2341cc8577df588a8cb569f6f3c91cd3
https://doi.org/10.1016/j.jep.2014.07.024
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7
Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques
Autor: Alvin W. Hung, John Liang Kuan Wee, Yvonne Tan, Jianhe Peng, Jung Hyun Min, Rong Li, Wei Guang Seetoh, Horst Flotow, Anna Ngo, Liling Wu, Ernesto Guccione, Joma Joy, Xiaoying Koh-Stenta, Yoonjung Shim, Jing Cao, Jeffrey Hill, Umayal Lakshmanan, Perlyn Zekui Kwek, Anders Poulsen
Publikováno v: Biochemical Journal. 461:323-334
PRDM proteins have emerged as important regulators of disease and developmental processes. To gain insight into the mechanistic actions of the PRDM family, we have performed comprehensive characterization of a prototype member protein, the histone me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2accddb125b822ba5a80af4a8e5658
https://doi.org/10.1042/bj20140374
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8
Disrupting the Constitutive, Homodimeric Protein-Protein Interface in CK2β Using a Biophysical Fragment-Based Approach
Autor: Wei-Guang, Seetoh, Chris, Abell
Publikováno v: Journal of the American Chemical Society
Identifying small molecules that induce the disruption of constitutive protein–protein interfaces is a challenging objective. Here, a targeted biophysical screening cascade was employed to specifically identify small molecules that could disrupt th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ea50a91c6ab0983fb1e8e51de5eb189
https://pubmed.ncbi.nlm.nih.gov/27726344
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9
Mass Spectrometry Reveals Protein Kinase CK2 High-Order Oligomerization via the Circular and Linear Assembly
Autor: Wei-Guang Seetoh, Chris Abell, Daniel Shiu-Hin Chan, Dijana Matak-Vinkovic
Publikováno v: ACS chemical biology. 11(6)
CK2 is an intrinsically active protein kinase that is crucial for cellular viability. However, conventional kinase regulatory mechanisms do not apply to CK2, and its mode of regulation remains elusive. Interestingly, CK2 is known to undergo reversibl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad893a8a36baf35825b9034b42cd1467
https://pubmed.ncbi.nlm.nih.gov/26999075
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