Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Wei-Fang Shen"'
Publikováno v:
Molecular and Cellular Biology. 29:5181-5192
While investigating the mechanism of action of the HOXA9 protein, we serendipitously identified Meis1 as a HOXA9 regulatory target. Since HOXA9 and MEIS1 play key developmental roles, are cooperating DNA binding proteins and leukemic oncoproteins, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bcd8043d764b5cc9ee3a65244b8164
https://doi.org/10.1128/mcb.00545-09
https://doi.org/10.1128/mcb.00545-09
Publikováno v:
Journal of Biological Chemistry. 279:39895-39904
Although HOXB6 and other HOX genes have previously been associated with hematopoiesis and leukemias, the precise mechanism of action of their protein products remains unclear. Here we use a biological model in which HOXB6 represses alpha- and gamma-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f539bb2aff6a6c43e0855c3d8bcbe7be
https://doi.org/10.1074/jbc.m404132200
https://doi.org/10.1074/jbc.m404132200
Autor:
David Stokoe, Neal Fischbach, Wei-Fang Shen, Corey Largman, Christian Brandts, H. Jeffrey Lawrence, Ulka Vijapurkar
Publikováno v:
Molecular and Cellular Biology. 24:3827-3837
HOXA9 expression is a common feature of acute myeloid leukemia, and high-level expression is correlated with poor prognosis. Moreover, HOXA9 overexpression immortalizes murine marrow progenitors that are arrested at a promyelocytic stage of different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e3452c78d3ba216b8dd5d058fc78ab
https://doi.org/10.1128/mcb.24.9.3827-3837.2004
https://doi.org/10.1128/mcb.24.9.3827-3837.2004
Autor:
Eric Stelnicki, Angela Kwong, László G. Kömüves, Theadora Mauro, Anastasia Blink, Sophia Rozenfeld, Billy Y. B. Lau, Corey Largman, Wei-Fang Shen, Keerthi Krishnan, Yuko Oda
Publikováno v:
Developmental Dynamics. 218:636-647
HOX homeodomain proteins are master developmental regulators, which are now thought to function as transcription factors by forming cooperative DNA binding complexes with PBX or other protein partners. Although PBX proteins exhibit regulated subcellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2e1602a03399050b37bce1fde29266
https://doi.org/10.1002/1097-0177(2000)9999:9999<::aid-dvdy1014>3.0.co
https://doi.org/10.1002/1097-0177(2000)9999:9999<::aid-dvdy1014>3.0.co
Publikováno v:
Journal of Biological Chemistry. 272:8198-8206
Previous studies showed that the Hox homeodomain proteins from paralog groups 1-8 display cooperative DNA binding with the non-Hox homeodomain protein Pbx, mediated by a canonical YPWM. Although the Abd-B-like Hox proteins in paralogs 9-13 lack this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8054ac3da114e93188e4dd7468aed40
https://doi.org/10.1074/jbc.272.13.8198
https://doi.org/10.1074/jbc.272.13.8198
Publikováno v:
Molecular and Cellular Biology. 16:1734-1745
Pbx cofactors are implicated to play important roles in modulating the DNA-binding properties of heterologous homeodomain proteins, including class I Hox proteins. To assess how Pbx proteins influence Hox DNA-binding specificity, we used a binding-si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6982ca3374db71e610e4af9bde7431
https://doi.org/10.1128/mcb.16.4.1734
https://doi.org/10.1128/mcb.16.4.1734
Autor:
M Lu, Corey Largman, Wei-Fang Shen, C P Chang, H J Lawrence, Michael L. Cleary, RK Humphries, S Rozenfeld, Guy Sauvageau
Publikováno v:
Nucleic Acids Research. 24:898-906
Eight of the nine homeobox genes of the Hoxb locus encode proteins which contain a conserved hexapeptide motif upstream from the homeodomain. All eight proteins (Hoxb-1-Hoxb-8) bind to a target oligonucleotide in the presence of Pbx1a under condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97c6741dec012502917a996827800cf
https://doi.org/10.1093/nar/24.5.898
https://doi.org/10.1093/nar/24.5.898
Publikováno v:
Nucleic Acids Research
HOXA9-mediated up-regulation of miR-155 was noted during an array-based analysis of microRNA expression in Hoxa9(-/-)bone marrow (BM) cells. HOXA9 induction of miR-155 was confirmed in these samples, as well as in wild-type versus Hoxa9-deficient mar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fc20d4f54d82f9defe9c48d55002fc
https://pubmed.ncbi.nlm.nih.gov/20444872
https://pubmed.ncbi.nlm.nih.gov/20444872
Autor:
H. J. Lawrence, C. H. E. Mathews, D. A. Morgan, Wei-Fang Shen, Corey Largman, K. Detmer, F. M. Hack
Publikováno v:
The EMBO Journal. 11:983-989
We have previously reported that certain genes of the HOX2 cluster of homeobox genes on human chromosome 17 are specifically expressed in human leukemic cell lines with erythroid potential, suggesting that these genes are involved in hematopoietic di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65a3a1c5ecb4a4f6c735b35a70785d6
https://doi.org/10.1002/j.1460-2075.1992.tb05137.x
https://doi.org/10.1002/j.1460-2075.1992.tb05137.x
Autor:
Teresa A. Simonitch-Eason, H. Jeffrey Lawrence, Wei-Fang Shen, Kristina Detmer, Corey Largman
Publikováno v:
Nucleic Acids Research. 19:539-545
The HOX 2.2 homeobox gene is expressed in human hematopoietic cell lines with erythroid features (W.-F. Shen, et al, Proc. Natl. Acad. Sci. 86, 8536-8540, 1989). Both human and murine Hox 2.2 genes contain a single 1 kb intron which interrupts the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad8ff2eadac75e5e6af08ba687973f8
https://doi.org/10.1093/nar/19.3.539
https://doi.org/10.1093/nar/19.3.539