Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Wei-Dong Yao"'
Autor:
Eunice W.M. Chin, Qi Ma, Hongyu Ruan, Camille Chin, Aditya Somasundaram, Chunling Zhang, Chunyu Liu, Martin D. Lewis, Melissa White, Tracey L. Smith, Malcolm Battersby, Wei-Dong Yao, Xin-Yun Lu, Wadih Arap, Julio Licinio, Ma-Li Wong
Publikováno v:
JCI Insight, Vol 7, Iss 14 (2022)
Synaptic dysfunction is a manifestation of several neurobehavioral and neurological disorders. A major therapeutic challenge lies in uncovering the upstream regulatory factors controlling synaptic processes. Plant homeodomain (PHD) finger proteins ar
Externí odkaz:
https://doaj.org/article/d81390da89e0491ca883d1a0e915b4cc
Publikováno v:
AIP Advances, Vol 12, Iss 3, Pp 035203-035203-6 (2022)
Nano-piezoelectric materials have drawn tremendous research interest. However, characterization of their piezoelectric properties, especially measuring the piezoelectric strain coefficients, remains a challenge. Normally, researchers use an AFM-based
Externí odkaz:
https://doaj.org/article/9f86ea6c5efa417f90da38c7346c4e3d
Autor:
Tao Yu, Rong-rong Wu, Federico Longhini, Bin Wang, Ming-fang Wang, Fang-fang Yang, Fu-zhou Hua, Wei-dong Yao, Xiao-ju Jin
Publikováno v:
Journal of International Medical Research, Vol 48 (2020)
Objective We investigated the “BURP” maneuver’s effect on the association between difficult laryngoscopy and difficult intubation, and predictors of a difficult airway. Methods Adult patients who underwent general anesthesia and tracheal intuba
Externí odkaz:
https://doaj.org/article/7292dcf0d88e4441a91d0f15903035d8
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183854 (2017)
We previously reported a 84-Kb hemi-deletion copy number variant at the SLC1A1 gene locus that reduces its expression and appeared causally linked to schizophrenia. In this report, we characterize the in vivo and in vitro consequences of reduced expr
Externí odkaz:
https://doaj.org/article/5a14fa7e071b45f8abfb826c65e99b00
Autor:
Hennady P Shulha, Jessica L Crisci, Denis Reshetov, Jogender S Tushir, Iris Cheung, Rahul Bharadwaj, Hsin-Jung Chou, Isaac B Houston, Cyril J Peter, Amanda C Mitchell, Wei-Dong Yao, Richard H Myers, Jiang-Fan Chen, Todd M Preuss, Evgeny I Rogaev, Jeffrey D Jensen, Zhiping Weng, Schahram Akbarian
Publikováno v:
PLoS Biology, Vol 10, Iss 11, p e1001427 (2012)
Cognitive abilities and disorders unique to humans are thought to result from adaptively driven changes in brain transcriptomes, but little is known about the role of cis-regulatory changes affecting transcription start sites (TSS). Here, we mapped i
Externí odkaz:
https://doaj.org/article/c30b9fddce6b4bb48ac08d60aa858ebe
Autor:
Alexis S. Zajicek, Hongyu Ruan, Huihui Dai, Mary C. Skolfield, Hannah L. Phillips, Wendi J. Burnette, Behnam Javidfar, Shao-Cong Sun, Schahram Akbarian, Wei-Dong Yao
Publikováno v:
Mol Psychiatry
The lysine-63 deubiquitinase cylindromatosis (CYLD) is long recognized as a tumor suppressor in immunity and inflammation and its loss-of-function mutations lead to familial cylindromatosis. However, recent studies reveal that CYLD is enriched in mam
Autor:
Behnam Javidfar, Wei-Dong Yao, Fatemeh Haghighi, M. Foo, C. P. Watkins, C. G. Hahn, Søren Heissel, H. L. Phillips, Schahram Akbarian, Sohit Miglani, Jennifer Blaze, Henrik Molina, B. Rostandy, Zachary T. Pennington, Albertas Navickas, Tao Pan, Hani Goodarzi, Denise J. Cai, Hanan Alwaseem, A. Plaza-Jennings, Sergio Espeso-Gil, Christopher D. Katanski, Hosseinali Asgharian
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
Epitranscriptomic mechanisms linking tRNA function and the brain proteome to cognition and complex behaviors are not well described. Here, we report bi-directional changes in depression-related behaviors after genetic disruption of neuronal tRNA cyto
Autor:
Wei-Dong Yao, Hongyu Ruan
Publikováno v:
Journal of Neurogenetics. 35:358-369
Addiction results from drug-elicited alterations of synaptic plasticity mechanisms in dopaminergic reward circuits. Impaired metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) and accumulation of synaptic Ca2+-permeable AMPA
Autor:
Hannah L. Phillips, Huihui Dai, So Yoen Choi, Karen Jansen-West, Alexis S. Zajicek, Luke Daly, Leonard Petrucelli, Fen-Biao Gao, Wei-Dong Yao
Publikováno v:
Neuron. 111:797-806.e6
Autor:
Rujia Dai, Richard F. Kopp, Chunling Zhang, Yi Jiang, Shishi Min, Ma-Li Wong, Wei-Dong Yao, Chunyu Liu, Hongyu Ruan, Chao Chen, Yan Xia, Qingtuan Meng, Chaodong Ding, Liz Kuney, Le Wang
Publikováno v:
Molecular psychiatry
Schizophrenia (SCZ) is a neuropsychiatric disorder with aberrant expression of multiple genes. However, identifying its exact causal genes remains a considerable challenge. The brain-specific transcription factor POU3F2 (POU domain, class 3, transcri