Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Wei-Chun Huangfu"'
Autor:
Sushree Shankar Panda, Chi-Chiu Lee, Khamushavalli Geevimaan, Kai-Chi Chen, Shung-Haur Yang, Chia-Ning Shen, Wei-Chun HuangFu, Han-Chung Wu
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-19 (2024)
Abstract Background Epithelial cell adhesion molecule (EpCAM) has been widely studied as a tumor antigen due to its expression in varieties of solid tumors. Moreover, the glycoprotein contributes to critical cancer-associated cellular functionalities
Externí odkaz:
https://doaj.org/article/ebea9f77cac94d27b2c3a20d54f81785
Autor:
Huang-Ju Tu, Min-Wu Chao, Cheng-Chung Lee, Chao-Shiang Peng, Yi-Wen Wu, Tony Eight Lin, Yu-Wei Chang, Shih-Chung Yen, Kai-Cheng Hsu, Shiow-Lin Pan, Wei-Chun HuangFu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Dual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer’s disease. Although the developm
Externí odkaz:
https://doaj.org/article/5af157fcd59d43dfa082d52baafe6400
Autor:
Tze‐Sian Chan, Li‐Hsin Cheng, Chung‐Chi Hsu, Pei‐Ming Yang, Tai‐Yan Liao, Hsiao‐Yen Hsieh, Pei‐Chun Lin, Wei‐Chun HuangFu, Chih‐Pin Chuu, Kelvin K. Tsai
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 562-579 (2024)
Notch signaling is aberrantly activated in approximately 30% of hepatocellular carcinoma (HCC), significantly contributing to tumorigenesis and disease progression. Expression of the major Notch receptor, NOTCH1, is upregulated in HCC cells and corre
Externí odkaz:
https://doaj.org/article/98d41b996f2a46b5a4a99daf235a8532
Autor:
Yi-Wen Wu, Min-Wu Chao, Huang-Ju Tu, Liang-Chieh Chen, Kai-Cheng Hsu, Jing-Ping Liou, Chia-Ron Yang, Shih-Chung Yen, Wei-Chun HuangFu, Shiow-Lin Pan
Publikováno v:
Oncogenesis, Vol 10, Iss 5, Pp 1-14 (2021)
Abstract Acute leukemia is a highly heterogeneous disease; therefore, combination therapy is commonly used for patient treatment. Drug–drug interaction is a major concern of combined therapy; hence, dual/multi-target inhibitors have become a domina
Externí odkaz:
https://doaj.org/article/8dd26522ac6d4593b41471029e8816c9
Autor:
Ting-Yi Sung, Han-Li Huang, Chun-Chun Cheng, Fu-Ling Chang, Po-Li Wei, Ya-Wen Cheng, Cheng-Chiao Huang, Yu-Ching Lee, Wei-Chun HuangFu, Shiow-Lin Pan
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Background The availability of a reliable tumor target for advanced colorectal cancer (CRC) therapeutic approaches is critical since current treatments are limited. Epidermal growth factor-like domain 6 (EGFL6) has been reported to be associ
Externí odkaz:
https://doaj.org/article/9bbf162c729e43c9b4a3fe7a24f4256f
Autor:
Min-Wu Chao, Tony Eight Lin, Wei-Chun HuangFu, Chao-Di Chang, Huang-Ju Tu, Liang-Chieh Chen, Shih-Chung Yen, Tzu-Ying Sung, Wei-Jan Huang, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 98-108 (2021)
The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 ki
Externí odkaz:
https://doaj.org/article/a23f5c3bf07c4ef483bac5eb846abc10
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background Despite the fact that histone deacetylase (HDAC) inhibitors have been tested to treat various cardiovascular diseases, the effects of selective HDAC6 inhibitor ACY1215 on infarct size during cardiac ischemia-reperfusion (IR) injur
Externí odkaz:
https://doaj.org/article/4f10a02731db406088ea9d201791927e
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0270539 (2022)
[This corrects the article DOI: 10.1371/journal.pone.0230943.].
Externí odkaz:
https://doaj.org/article/687249256f6d4f77bbe5dbe7ad05b114
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 11, Pp n/a-n/a (2020)
Abstract Background Mitochondrial DNA maintenance defects (MDMDs) is one of the critical pediatric dysfunction. One of the recent report indicated that a severe patient of MDMDs carries the NP_056528.2:p.Asn221Ser (N221S) variation in the RRM2B gene
Externí odkaz:
https://doaj.org/article/9b022b33f5d74de3b4be8aaafa24a596
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0230943 (2020)
Pericellular and extracellular proteoglycans play an important role in modulating morphogen gradients and signal transductions. Chondroitin sulfate proteoglycan 4 (Cspg4) is a membrane spanning proteoglycan expressed in immature progenitor cells and
Externí odkaz:
https://doaj.org/article/245e33e8b434415ab1d44b6d052f94be