Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Wei-Chen Dai"'
Autor:
Tian‐Hua Wei, Meng‐Yi Lu, Si‐Hui Yao, Yu‐Qi Hong, Jin Yang, Meng‐Yuan Zhang, Yu‐Qi Yin, Yu‐Jie Han, Qing‐Qing Li, Zi‐Xuan Wang, Yi‐Bo Wang, Zhen‐Jiang Tong, Yun Zhou, Wei‐Chen Dai, Yan‐Cheng Yu, Shan‐Liang Sun, Ye Yang, Nian‐Guang Li, Zhi‐Hao Shi
Publikováno v:
MedComm – Oncology, Vol 3, Iss 1, Pp n/a-n/a (2024)
Abstract Janus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited therapeutic benefits due to their lack of selectivity. This review focuses on the structur
Externí odkaz:
https://doaj.org/article/29262a2be1a6426fa1afb92378ccb3fb
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 11046-11062 (2015)
Thrombotic disorders represent the major share of the various cardiovascular diseases, and significant progress has been made in the development of synthetic thrombin inhibitors as new anticoagulants. In addition to the development of highly potent a
Externí odkaz:
https://doaj.org/article/1c70f1844f3e46b2b7ec1238d96d7318
Autor:
Wei-chen Dai, 戴維辰
102
The flow characteristics of the fans and thermal modules were experimentally investigated. Centrifugal and axial flow fans were selected in this work. The thermal modules were assemblies of fans and heatsinks. The laser-assisted smoke flow v
The flow characteristics of the fans and thermal modules were experimentally investigated. Centrifugal and axial flow fans were selected in this work. The thermal modules were assemblies of fans and heatsinks. The laser-assisted smoke flow v
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/8n863p
Autor:
Wei-Chen Dai, 戴維辰
99
Alzheimer’s disease (AD) is a neurodegenerative disease which leads to progressive neuronal death and dementia. One of the histopathological hallmarks of AD is the senile plaques. The primary component of senile plaques is ??amyloid peptide
Alzheimer’s disease (AD) is a neurodegenerative disease which leads to progressive neuronal death and dementia. One of the histopathological hallmarks of AD is the senile plaques. The primary component of senile plaques is ??amyloid peptide
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/63019607122172898598
Autor:
Qing‐Xin Wang, Yi‐Bo Wang, Jiu‐Kai Sha, Hai Zhou, Jia‐Chuan Liu, Jia‐Zhen Wu, Zhen‐Jiang Tong, Jiao Cai, Zi‐Jun Chen, Chen‐Qian Zhang, Xin‐Rui Zheng, Jing‐Jing Wang, Xiao‐Long Wang, Xin Xue, Yan‐Cheng Yu, Ning Ding, Xue‐Jiao Leng, Wei‐Chen Dai, Shan‐Liang Sun, Liang Chang, Nian‐Guang Li, Zhi‐Hao Shi
Publikováno v:
Drug Development Research. 84:296-311
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6899df1c68e1c20799636d9816200ece
https://doi.org/10.1002/ddr.22032
https://doi.org/10.1002/ddr.22032
Autor:
Qing-Xin Wang, Yu-Hao Cao, Li-Jin Yang, Yi-Yuan Ma, Nan Li, Shi-Han Wu, Lu Chen, Jia-Zhen Wu, Zhen-Jiang Tong, Xiao-Long Wang, Xin Xue, Ning Ding, Xue-Jiao Leng, Liang Chang, Wei-Chen Dai, Yan-Cheng Yu, Shan-Liang Sun, Ye Yang, Nian-Guang Li, Zhi-Hao Shi
Publikováno v:
Future Medicinal Chemistry. 15:57-71
Aim: The clinical benefits of FLT3 inhibitors against acute myeloid leukemia (AML) have been limited by selectivity and resistance mutations. Thus, to identify FLT3 inhibitors possessing high selectivity and potency is of necessity. Methods & results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4e2c6feedaad9225b8c2e4b4b234b20
https://doi.org/10.4155/fmc-2022-0231
https://doi.org/10.4155/fmc-2022-0231
Autor:
Zhi-Hao Shi, Nian-Guang Li, Shan-Liang Sun, Shi-Han Wu, Li-Jin Yang, Yi-Yuan Ma, Yu-Hao Cao, Zhen-Jiang Tong, Jia-Zhen Wu, Yi-Bo Wang, Jiu-Kai Sha, Ning Ding, Qiao-Li Liang, Liang Chang, Xiao-Long Wang, Jin-Ao Duan, Yan-Cheng Yu, Wei-Chen Dai, Ke Xie, Xue-Jiao Leng, Xin Xue
Publikováno v:
Letters in Drug Design & Discovery. 20
Background: Acute myeloid leukemia (AML) is the most common type of blood cancer. Fms-like tyrosine kinase 3 (FLT3) is a member of the class III receptor tyrosine kinase family. Overexpression of FLT3 was found in 70-100% of patients with acute myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9250921b9447897024d7ae8b81f00588
https://doi.org/10.2174/1570180820666230519140242
https://doi.org/10.2174/1570180820666230519140242
Autor:
Liang Chang, Qiao-Li Liang, Nian-Guang Li, Shan-Liang Sun, Xiao-Bin Dai, Shi-Han Wu, Ning Ding, Yi-Yuan Ma, Zhen-Jiang Tong, Jia-Zhen Wu, Yi-Bo Wang, Yan-Cheng Yu, Xue-Jiao Leng, Xin Xue, Jin-Guo Xu, Wei-Chen Dai, Ke Xie, Jing-Han Zhao, Yu-Qi Hong, Tian-Xi Lan, Tian-Yu Mu, Xiao-Long Wang
Publikováno v:
Letters in Drug Design & Discovery. 20
Background: Alzheimer’s disease (AD), a chronic neurodegenerative disorder predominantly occurs among the elderly, is the leading cause of dementia. The accumulation of β-amyloid (Aβ) is considered the main pathogenies of AD, and β-site APP-clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39196b9a437c00d50c0a0593f56125f8
https://doi.org/10.2174/1570180820666230223151850
https://doi.org/10.2174/1570180820666230223151850
Autor:
Ji-Bo Kang, Lu Chen, Xue-Jiao Leng, Jing-Jing Wang, Yang Cheng, Shi-Han Wu, Yi-Yuan Ma, Li-Jin Yang, Yu-Hao Cao, Xiao Yang, Zhen-Jiang Tong, Jia-Zhen Wu, Yi-Bo Wang, Hai Zhou, Jia-Chuan Liu, Ning Ding, Wei-Chen Dai, Yan-Cheng Yu, Xin Xue, Shan-Liang Sun, Xiao-Bin Dai, Liang Chang, Xiao-Long Wang, Nian-Guang Li, Zhi-Hao Shi
Publikováno v:
Bioorganicmedicinal chemistry. 70
Fms-like tyrosine kinase 3 (FLT3) mutation has been strongly associated with increased risk of relapse, and the irreversible covalent FLT3 inhibitors had the potential to overcome the drug-resistance. In this study, a series of simplified 4-(4-aminop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f183b4608b5e09496d050351a434d1ef
https://pubmed.ncbi.nlm.nih.gov/35863236
https://pubmed.ncbi.nlm.nih.gov/35863236
Publikováno v:
Molecules
Volume 25
Issue 23
Molecules, Vol 25, Iss 5586, p 5586 (2020)
Volume 25
Issue 23
Molecules, Vol 25, Iss 5586, p 5586 (2020)
Background: Microtubule-targeted drugs are the most effective drugs for adult patients with certain solid tumors. Taccalonolide AJ (AJ) can stabilize tubulin polymerization by covalently binding to &beta
tubulin, which enables it to play a role
tubulin, which enables it to play a role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8070142624e5954c3c0daf9cbbea9f7