Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Wei Yuan Hsieh"'
Autor:
Joseph P. Argus, Moses Q. Wilks, Quan D. Zhou, Wei Yuan Hsieh, Elvira Khialeeva, Xen Ping Hoi, Viet Bui, Shili Xu, Amy K. Yu, Eric S. Wang, Harvey R. Herschman, Kevin J. Williams, Steven J. Bensinger
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2919-2934.e8 (2018)
Summary: It is well understood that fatty acids can be synthesized, imported, and modified to meet requisite demands in cells. However, following the movement of fatty acids through the multiplicity of these metabolic steps has remained difficult. To
Externí odkaz:
https://doaj.org/article/482a607cb48f49f9b41f5484a29a328c
Autor:
Kevin A Robertson, Wei Yuan Hsieh, Thorsten Forster, Mathieu Blanc, Hongjin Lu, Peter J Crick, Eylan Yutuc, Steven Watterson, Kimberly Martin, Samantha J Griffiths, Anton J Enright, Mami Yamamoto, Madapura M Pradeepa, Kimberly A Lennox, Mark A Behlke, Simon Talbot, Jürgen Haas, Lars Dölken, William J Griffiths, Yuqin Wang, Ana Angulo, Peter Ghazal
Publikováno v:
PLoS Biology, Vol 14, Iss 3, p e1002364 (2016)
In invertebrates, small interfering RNAs are at the vanguard of cell-autonomous antiviral immunity. In contrast, antiviral mechanisms initiated by interferon (IFN) signaling predominate in mammals. Whilst mammalian IFN-induced miRNA are known to inhi
Externí odkaz:
https://doaj.org/article/2a7e4b86c96d49edbfa01de93c137949
Autor:
Kai A Kropp, Wei Yuan Hsieh, Elena Isern, Thorsten Forster, Eva Krause, Wolfram Brune, Ana Angulo, Peter Ghazal
Publikováno v:
PLoS Pathogens, Vol 11, Iss 4, p e1004737 (2015)
Viral engagement with macrophages activates Toll-Like-Receptors (TLRs) and viruses must contend with the ensuing inflammatory responses to successfully complete their replication cycle. To date, known counter-strategies involve the use of viral-encod
Externí odkaz:
https://doaj.org/article/c1d165f3a79f4109a0475fd6f6bc3ca8
Autor:
Sara Rodríguez-Martín, Kai Alexander Kropp, Vanessa Wilhelmi, Vanda Juranic Lisnic, Wei Yuan Hsieh, Mathieu Blanc, Andrew Livingston, Andreas Busche, Hille Tekotte, Martin Messerle, Manfred Auer, Iain Fraser, Stipan Jonjic, Ana Angulo, Matthias J Reddehase, Peter Ghazal
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002901 (2012)
Little is known about the role of viral genes in modulating host cytokine responses. Here we report a new functional role of the viral encoded IE1 protein of the murine cytomegalovirus in sculpting the inflammatory response in an acute infection. In
Externí odkaz:
https://doaj.org/article/5b34cf90ffe1437d9285452e042e5dd5
Autor:
Mathieu Blanc, Wei Yuan Hsieh, Kevin A Robertson, Steven Watterson, Guanghou Shui, Paul Lacaze, Mizanur Khondoker, Paul Dickinson, Garwin Sing, Sara Rodríguez-Martín, Peter Phelan, Thorsten Forster, Birgit Strobl, Matthias Müller, Rudolph Riemersma, Timothy Osborne, Markus R Wenk, Ana Angulo, Peter Ghazal
Publikováno v:
PLoS Biology, Vol 9, Iss 3, p e1000598 (2011)
Little is known about the protective role of inflammatory processes in modulating lipid metabolism in infection. Here we report an intimate link between the innate immune response to infection and regulation of the sterol metabolic network characteri
Externí odkaz:
https://doaj.org/article/cc2f259066284ec9a4077c68a828c24a
Autor:
Alessandra Ferrari, Quan D. Zhou, Kevin J. Williams, Cuiwen He, An-Chieh Feng, Robert Damoiseaux, Philip O. Scumpia, Autumn G. York, Min Sub Lee, Elizabeth J. Tarling, Allison E. Daly, Viet L. Bui, Steven J. Bensinger, Wei Yuan Hsieh, Eliza B. Kronenberger, Stephen T. Smale, Xun Chi, Jonathan J. Mkrtchyan, Xu Xiao, Peter Tontonoz
Publikováno v:
Nature Immunology. 21:746-755
Plasma membranes of animal cells are enriched for cholesterol. Cholesterol-dependent cytolysins (CDCs) are pore-forming toxins secreted by bacteria that target membrane cholesterol for their effector function. Phagocytes are essential for clearance o
A DMS Shotgun Lipidomics Workflow Application to Facilitate HighThroughput, Comprehensive Lipidomics
Autor:
Wei Yuan Hsieh, Niek Blomberg, Michael Snyder, Daniel Hornburg, Lisa F. Bettcher, Mackenzie J Pearson, Daniel Raftery, Kevin J. Williams, Martin Giera, Baolong Su, Steven J. Bensinger
Publikováno v:
Journal of the American Society for Mass Spectrometry, vol 32, iss 11
J Am Soc Mass Spectrom
Journal of The American Society for Mass Spectrometry, 32(11), 2655-2663. AMER CHEMICAL SOC
J Am Soc Mass Spectrom
Journal of The American Society for Mass Spectrometry, 32(11), 2655-2663. AMER CHEMICAL SOC
Differential mobility spectrometry (DMS) is highly useful for shotgun lipidomic analysis because it overcomes difficulties in measuring isobaric species within a complex lipid sample and allows for acyl tail characterization of phospholipid species.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3615d306be692ee82ea17fe475393b8
https://hdl.handle.net/1887/3243117
https://hdl.handle.net/1887/3243117
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 1, Pp 100235-(2021)
STAR protocols, vol 2, iss 1
STAR Protocols, Vol 2, Iss 1, Pp 100235-(2021)
STAR protocols, vol 2, iss 1
Summary Immune cells, such as macrophages, reprogram their lipid metabolism in response to the activation of pattern recognition receptors (e.g., TLRs, NLRs) and cytokine receptors (e.g., interferons, interleukins). Profiling these changes can be ach
Autor:
Wei Yuan Hsieh, Xen Ping Hoi, Viet L. Bui, Elvira Khialeeva, Xun Chi, Autumn G. York, Young Min Son, Amber Kaplan, Ajit S. Divakaruni, Jie Sun, Richard A. Flavell, Quan D. Zhou, Eliza B. Kronenberger, Stephen T. Smale, Philip O. Scumpia, Kevin J. Williams, Baolong Su, Steven J. Bensinger
Publikováno v:
Cell metabolism, vol 32, iss 1
Cell Metab
Cell Metab
Macrophages reprogram their lipid metabolism in response to activation signals. However, a systems-level understanding of how different pro-inflammatory stimuli reshape the macrophage lipidome is lacking. Here, we use complementary "shotgun" and isot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec926f48f640925b23bd5002d454a6d
https://escholarship.org/uc/item/0t2554sn
https://escholarship.org/uc/item/0t2554sn
Autor:
Quan D, Zhou, Xun, Chi, Min Sub, Lee, Wei Yuan, Hsieh, Jonathan J, Mkrtchyan, An-Chieh, Feng, Cuiwen, He, Autumn G, York, Viet L, Bui, Eliza B, Kronenberger, Alessandra, Ferrari, Xu, Xiao, Allison E, Daly, Elizabeth J, Tarling, Robert, Damoiseaux, Philip O, Scumpia, Stephen T, Smale, Kevin J, Williams, Peter, Tontonoz, Steven J, Bensinger
Publikováno v:
Nature immunology. 21(7)
Plasma membranes of animal cells are enriched for cholesterol. Cholesterol-dependent cytolysins (CDCs) are pore-forming toxins secreted by bacteria that target membrane cholesterol for their effector function. Phagocytes are essential for clearance o