Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Wei Xin Chin"'
Autor:
Bowen Yi, Benjamin Xuan Zheng Chew, Huixin Chen, Regina Ching Hua Lee, Yuhui Deborah Fong, Wei Xin Chin, Chee Keng Mok, Justin Jang Hann Chu
Publikováno v:
Viruses, Vol 15, Iss 6, p 1377 (2023)
Dengue virus (DENV) is the cause of dengue fever, infecting 390 million people worldwide per year. It is transmitted to humans through the bites of mosquitoes and could potentially develop severe symptoms. In spite of the rising social and economic i
Externí odkaz:
https://doaj.org/article/09b3805778d648c7b3a8c2b968e5c676
Autor:
Koji Ichiyama, Sindhoora Bhargavi Gopala Reddy, Li Feng Zhang, Wei Xin Chin, Tegshi Muschin, Lars Heinig, Youichi Suzuki, Haraprasad Nanjundappa, Yoshiyuki Yoshinaka, Akihide Ryo, Nobuo Nomura, Eng Eong Ooi, Subhash G Vasudevan, Takashi Yoshida, Naoki Yamamoto
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 4, p e2188 (2013)
Curdlan sulfate (CRDS), a sulfated 1→3-β-D glucan, previously shown to be a potent HIV entry inhibitor, is characterized in this study as a potent inhibitor of the Dengue virus (DENV). CRDS was identified by in silico blind docking studies to exhi
Externí odkaz:
https://doaj.org/article/158f253f00b2400abb1aa06881da6bee
Autor:
Wei-Xin Chin, Regina Ching Hua Lee, Parveen Kaur, Tian Sheng Lew, Thinesshwary Yogarajah, Hao Yuin Kong, Zi-Yun Teo, Cyrill Kafi Salim, Rong-Rong Zhang, Xiao-Feng Li, Sylvie Alonso, Cheng-Feng Qin, Justin Jang Hann Chu
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract The mosquito-borne Zika virus is an emerging pathogen from the Flavivirus genus for which there are no approved antivirals or vaccines. Using the clinically validated PDK-53 dengue virus vaccine strain as a backbone, we created a chimeric de
Externí odkaz:
https://doaj.org/article/96aefe18a1c54f6fb1c868ba72e76b1d
Autor:
Chu, Bowen Yi, Benjamin Xuan Zheng Chew, Huixin Chen, Regina Ching Hua Lee, Yuhui Deborah Fong, Wei Xin Chin, Chee Keng Mok, Justin Jang Hann
Publikováno v:
Viruses; Volume 15; Issue 6; Pages: 1377
Dengue virus (DENV) is the cause of dengue fever, infecting 390 million people worldwide per year. It is transmitted to humans through the bites of mosquitoes and could potentially develop severe symptoms. In spite of the rising social and economic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::498c6c9dbd99e3d30bf2a106fcb2c81f
Autor:
Dayna, Cheng, Sheng-Wen, Huang, Wei-Xin, Chin, Su-Jhen, Hung, Huey-Pin, Tsai, Justin Jang Hann, Chu, Chiao-Hsuan, Chao, Jen-Ren, Wang
Publikováno v:
Frontiers in Microbiology. 13
Due to the nature of RNA viruses, their high mutation rates produce a population of closely related but genetically diverse viruses, termed quasispecies. To determine the role of quasispecies in DENV disease severity, 22 isolates (10 from mild cases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6ce5cff0358c6c474f0c98eca42979
https://doi.org/10.3389/fmicb.2022.894200
https://doi.org/10.3389/fmicb.2022.894200
Publikováno v:
Biochemical Pharmacology. 154:54-63
Despite the ever-increasing global incidence of dengue fever, there are no specific chemotherapy regimens for its treatment. Structural studies on dengue virus (DENV) proteins have revealed potential drug targets. Major DENV proteins such as the enve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d55ceef4d773834fe545e6aa42f8d02
https://doi.org/10.1016/j.bcp.2018.04.008
https://doi.org/10.1016/j.bcp.2018.04.008
Autor:
Jing Kai Lee, Jane Li Min Chui, Hao Yuin Kong, Regina Ching Hua Lee, Wei-Xin Chin, Justin Jang Hann Chu
Publikováno v:
Antiviral research. 171
Dengue virus, the causative agent for the dengue fever, infects approximately 50-100 million people worldwide per year. The high incidence of dengue fever, along with its potential to develop into a severe, life-threatening form, resulted in great in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c787d462b9c10f9ec8d4b4946fac65
https://pubmed.ncbi.nlm.nih.gov/31421165
https://pubmed.ncbi.nlm.nih.gov/31421165
Autor:
Zi Yun Teo, Marcus Wing Choy Loe, Erwei Hao, Justin Jang Hann Chu, Hou Xiaotao, Isabelle Xin Yu Zhu, Jiagang Deng, Li Cong, Meiling Chen, Regina Ching Hua Lee, Wei-Xin Chin
Publikováno v:
Antiviral Research. 184:104954
Dengue virus (DENV) is an arthropod-borne virus that has developed into a prominent global health threat in recent decades. The main causative agent of dengue fever, the virus infects an estimated 390 million individuals across the globe each year. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055e08c310d3fd91c8ef9fc56d5c380d
https://doi.org/10.1016/j.antiviral.2020.104954
https://doi.org/10.1016/j.antiviral.2020.104954
Publikováno v:
Drug discovery today. 22(1)
In invertebrate eukaryotes and prokaryotes, respectively, the RNAi and clustered regularly interspaced short palindromic repeats-CRISPR-associated (CRISPR-Cas) pathways are highly specific and efficient RNA and DNA interference systems, and are well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170f6818944ff4e5157aa0c398e18b53
https://pubmed.ncbi.nlm.nih.gov/27575999
https://pubmed.ncbi.nlm.nih.gov/27575999
Autor:
Tatsuya Sawasaki, Ching Hua Lee, Subhash G. Vasudevan, Kenji Ohba, Kouichi Sano, Hirotaka Takahashi, Yoshio Koyanagi, Hirotaka Ebina, Toshifumi Matsuyama, Yee-Joo Tan, Wei Xin Chin, Justin Jang Hann Chu, Beng Hui Tan, Zhi Wen Eyo, Takayuki Hishiki, Qi'En Han, Youichi Suzuki, Chikako Takahashi, Naoki Yamamoto, Koji Ichiyama
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 1, p e1005357 (2016)
PLoS Pathogens, Vol 12, Iss 1, p e1005357 (2016)
Dengue virus (DENV) is one of the most important arthropod-borne pathogens that cause life-threatening diseases in humans. However, no vaccine or specific antiviral is available for dengue. As seen in other RNA viruses, the innate immune system plays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f2cf8b55415d80d97e743e6cb9908e
https://pubmed.ncbi.nlm.nih.gov/26735137
https://pubmed.ncbi.nlm.nih.gov/26735137