Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Wei Wen Lim"'
Autor:
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Brijesh K. Singh, Sonia P. Chothani, Benjamin Ng, Wei Wen Lim, Jin Zhou, Madhulika Tripathi, Nicole S. J. Ko, Shamini G. Shekeran, Jessie Tan, Sze Yun Lim, Mao Wang, Pei Min Lio, Paul M. Yen, Sebastian Schafer, Stuart A. Cook, Anissa A. Widjaja
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
IL11 contributes to the development of non-alcoholic steatohepatitis (NASH) through incompletely understood mechanisms. Here, the authors report that lipotoxicity-driven autocrine IL11 activity underlies hepatocyte metabolic dysfunction and death via
Externí odkaz:
https://doaj.org/article/ce2b5ee017d5453ea86274564e8eb24f
Autor:
Benjamin Ng, Kevin Y. Huang, Chee Jian Pua, Sivakumar Viswanathan, Wei-Wen Lim, Fathima F. Kuthubudeen, Yu-Ning Liu, An An Hii, Benjamin L. George, Anissa A. Widjaja, Enrico Petretto, Stuart A. Cook
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract In lung disease, persistence of KRT8-expressing aberrant basaloid cells in the alveolar epithelium is associated with impaired tissue regeneration and pathological tissue remodeling. We analyzed single cell RNA sequencing datasets of human i
Externí odkaz:
https://doaj.org/article/07484aadbfc741bd92d4fb8436b32283
Autor:
Wei-Wen Lim, Jason H. Leung, Chen Xie, Angelina W. T. Cheng, Liping Su, Luh-Nah Lum, Aishah Toh, Siew-Ching Kong, Angela M. Takano, Derek J. Hausenloy, Yang C. Chua
Publikováno v:
Diseases, Vol 12, Iss 9, p 221 (2024)
Identifying biomarkers in non-small cell lung cancer (NSCLC) can improve diagnosis and patient stratification. We evaluated plasmas and sera for interleukins (IL)-11, IL-6, IL-8, IL-17A, and IL-33 as biomarkers in primary NSCLC patients undergoing su
Externí odkaz:
https://doaj.org/article/06f0f0fa1847452b9b367e3d9f1d5aec
Autor:
Liang Su Toh1 liangsutoh97@gmail.com, Wei Wen Lim, Eugene1 eugenelww@gmail.com, Kamaruzali, Mohd Afiq1 afiqkmz@gmail.com, Jusoh, Mashitah1 mashitahj@upm.edu.my, Mujab, Azzami Adam Muhamad2 azzami@mardi.gov.my, Khalid, Khalisanni3 sanni@mardi.gov.my, Baharudin, Sarah1 sarahbaharudin@upm.edu.my, Abdullah, Amir Shahidul Nillah4 amirnillah@gmail.com, Isa, Hassim Mohamad4 hassim@esi.com.my, Yaapar, Muhammad Nazmin1 muhdnazmin@upm.edu.my
Publikováno v:
Pertanika Journal of Tropical Agricultural Science. Feb2024, Vol. 47 Issue 1, p57-76. 20p.
Autor:
Benjamin Ng, Chen Xie, Liping Su, Fathima F. Kuthubudeen, Xiu-Yi Kwek, Daryl Yeong, Chee Jian Pua, Stuart A. Cook, Wei-Wen Lim
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 43:739-754
Background: Marfan Syndrome (MFS) is an inherited connective tissue disorder caused by mutations in the FBN1 (fibrillin-1) gene. Lung abnormalities are common in MFS, but their pathogenesis is poorly understood. IL11 (interleukin-11) causes aortic di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88a061a03cd94b575fd6255544158f00
https://doi.org/10.1161/atvbaha.122.318802
https://doi.org/10.1161/atvbaha.122.318802
Autor:
Mark Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Konstantinos Vanezis, Ivan Andrew, Wei-Wen Lim, Anissa Widjaja, Paul JR Barton, Stuart A Cook
Background: Cardiac fibrosis is a common pathological process in heart disease and represents a therapeutic target. TGFβ is the canonical driver of cardiac fibrosis and was recently shown to be dependent on IL11 for its profibrotic effects in fibrob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398b360f97c6c78f805604d6c92cc392
https://doi.org/10.1101/2023.05.23.541928
https://doi.org/10.1101/2023.05.23.541928
Autor:
Xiu-Yi Kwek, Andrew R. Hall, Wei-Wen Lim, Khairunnisa Katwadi, Poh Loong Soong, Elina Grishina, Kun-Han Lin, Gustavo Crespo-Avilan, En Ping Yap, Nur Izzah Ismail, Kroekkiat Chinda, Ying Ying Chung, Heming Wei, Winston Shim, David Montaigne, Andrew Tinker, Sang-Bing Ong, Derek J. Hausenloy
Publikováno v:
Scientific Reports. 12
Mitochondrial dysfunction induced by acute cardiac ischemia–reperfusion (IR), may increase susceptibility to arrhythmias by perturbing energetics, oxidative stress production and calcium homeostasis. Although changes in mitochondrial morphology are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d47b9eedc9ba586d15ea13dca89baa9a
https://doi.org/10.1038/s41598-022-25625-0
https://doi.org/10.1038/s41598-022-25625-0
Autor:
Benjamin Ng, Kevin Y. Huang, Chee Jian Pua, Wei-Wen Lim, Fathima Kuthubudeen, An An Hii, Sivakumar Viswanathan, Enrico Petretto, Stuart A. Cook
Following lung injury, alveolar regeneration is characterized by the transformation of alveolar type 2 (AT2) cells, via a transitional KRT8+ state, into alveolar type 1 (AT1) cells. In lung disease, dysfunctional intermediate cells accumulate, AT1 ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8812f82eaf9a6c51a668d47ac6f1345f
https://doi.org/10.1101/2022.11.11.516109
https://doi.org/10.1101/2022.11.11.516109
Autor:
Anissa A. Widjaja, Sivakumar Viswanathan, Joyce Goh Wei Ting, Jessie Tan, Shamini G. Shekeran, David Carling, Wei-Wen Lim, Stuart A. Cook
IL11 initiates fibroblast activation but also causes epithelial cell dysfunction. The mechanisms underlying these processes are not known. We report that IL11-stimulated ERK/P90RSK activity causes the phosphorylation of LKB1 at S325 and S428, leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bce57294de80ed0064c8eee4530263
http://hdl.handle.net/10044/1/99303
http://hdl.handle.net/10044/1/99303
Autor:
Anissa A. Widjaja, Sonia Chothani, Sivakumar Viswanathan, Joyce Goh Wei Ting, Wei-Wen Lim, Stuart A. Cook
Interleukin 11 (IL11) is upregulated in inflammatory conditions where it is believed to have anti-inflammatory activity. However, recent studies suggest instead that IL11 may promote inflammation, via the stroma. Here, we assessed whether IL11 is pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::087bea58fd009429dfa1a065c9194c0f
https://doi.org/10.1101/2022.07.08.499236
https://doi.org/10.1101/2022.07.08.499236