Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism.

Autor: Diana C Odermatt, Wei Ting C Lee, Sebastian Wild, Stanislaw K Jozwiakowski, Eli Rothenberg, Kerstin Gari

Publikováno v: PLoS Genetics, Vol 16, Iss 6, p e1008740 (2020)

FANCJ/BRIP1 is an iron-sulfur (FeS) cluster-binding DNA helicase involved in DNA inter-strand cross-link (ICL) repair and G-quadruplex (G4) metabolism. Mutations in FANCJ are associated with Fanconi anemia and an increased risk for developing breast

Externí odkaz: https://doaj.org/article/5ba9429496e64078af68f76d1c54c78e

A basal-level activity of ATR links replication fork surveillance and stress response

Autor: Peter Tonzi, Yandong Yin, Huijun Xue, Tony T. Huang, James A. Borowiec, Wei Ting C. Lee, Mauro Modesti, Eli Rothenberg, Dipika Gupta

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2021, 81 (20), pp.4243-4257.e6. ⟨10.1016/j.molcel.2021.08.009⟩
Mol Cell
Molecular Cell, 2021, 81 (20), pp.4243-4257.e6. ⟨10.1016/j.molcel.2021.08.009⟩

Mammalian cells employ diverse pathways to prevent deleterious consequences during DNA replication, yet the mechanism by which cells survey individual replisomes to detect spontaneous replication impediments at the basal level, and their accumulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afebc7c3755ac78a83ae9356c99129a7
https://hal-amu.archives-ouvertes.fr/hal-03438618

Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling

Autor: Sharon B. Cantor, Diana C. Odermatt, Peter Tonzi, Tony T. Huang, Pam Pam Gwo, Mauro Modesti, Michael J. Morten, Kerstin Gari, Wei Ting C. Lee, Yandong Yin, Eli Rothenberg

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-22830-9⟩
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-22830-9⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Guanine-rich DNA sequences occur throughout the human genome and can transiently form G-quadruplex (G4) structures that may obstruct DNA replication, leading to genomic instability. Here, we apply multi-color single-molecule localization microscopy (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb4384b898bd85fb80ffff412103759
http://europepmc.org/articles/PMC8099879

Super-resolution visualization of distinct stalled and broken replication fork structures

Autor: Yu Tina Kong, Frances Marks, Wei Ting C. Lee, Donna R. Whelan, Yandong Yin, Eli Rothenberg

Publikováno v: PLoS Genetics, Vol 16, Iss 12, p e1009256 (2020)
PLoS Genetics

Endogenous genotoxic stress occurs in healthy cells due to competition between DNA replication machinery, and transcription and topographic relaxation processes. This causes replication fork stalling and regression, which can further collapse to form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e715638f7d9c7998ca8ef8ca819e51c2
https://doi.org/10.1101/2020.01.19.912014

Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks

Autor: Sarah Keegan, Dylan M. Ofri, Wei Ting C. Lee, Donna R. Whelan, Eli Rothenberg, Yandong Yin, Keria Bermudez-Hernandez, David Fenyö

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Homologous recombination (HR) is a crucial pathway for the repair of DNA double-strand breaks. BRCA1/2 breast cancer proteins are key players in HR via their mediation of RAD51 nucleofilament formation and function; however, their individual roles an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83ea9899536ba7acb1a2baa507e06fe
https://doaj.org/article/7dede67c47fa41e5b8e6f07d588a1c84