Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Wei Sheng Yap"'
Publikováno v:
Bio-Protocol, Vol 14, Iss 19 (2024)
Phosphoinositides are rare membrane lipids that mediate cell signaling and membrane dynamics. PI(4)P and PI(3)P are two major phosphoinositides crucial for endolysosomal functions and dynamics, making them the lipids of interest in many studies. The
Externí odkaz:
https://doaj.org/article/b22775fd239d41959e57ae1097ca0bf3
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100868- (2021)
Summary: The endoplasmic reticulum (ER) stress is defined by the accumulation of unfolded proteins at the ER and perturbation at the ER membrane, known as lipid bilayer stress (LBS). In turn, ER stress triggers the unfolded protein response (UPR) to
Externí odkaz:
https://doaj.org/article/6661caeeb2ae4c27a919f089e5cb5698
Autor:
Dinesh Kumar Chellappan, Richie R. Bhandare, Afzal B. Shaik, Krishna Prasad, Nurfatihah Azlyna Ahmad Suhaimi, Wei Sheng Yap, Arpita Das, Pradipta Banerjee, Nandini Ghosh, Tanner Guith, Amitava Das, Sarannya Balakrishnan, Mayuren Candasamy, Jayashree Mayuren, Kishneth Palaniveloo, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9470 (2022)
Diabetes is an endocrinological disorder with a rapidly increasing number of patients globally. Over the last few years, the alarming status of diabetes has become a pivotal factor pertaining to morbidity and mortality among the youth as well as midd
Externí odkaz:
https://doaj.org/article/a2877d6b7e9f4eaebb9694605a7e94da
Publikováno v:
Progress in lipid research. 89
The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many cellular pathways, including protein synthesis, protein quality control, and lipid synthesis. When one or multiple ER roles are dysregulated and saturated, the ER e
Autor:
Wei Sheng, Yap, Guillaume, Thibault
Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms upon stress. One of the best characterised pathways with wide implications in disease, the unfolded protein response (UPR), is the endoplasmic reticulum (ER) gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd8fbfa6f8b49031d40238b2374f6de
Autor:
Wei Sheng Yap
Publikováno v:
Journal of Cell Science. 133
First Person is a series of interviews with the first authors of a selection of papers published Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Wei Sheng Yap is first author on ‘The yeast FIT2 h
Autor:
Wei Sheng, Yap, Peter, Shyu, Maria Laura, Gaspar, Stephen A, Jesch, Charlie, Marvalim, William A, Prinz, Susan A, Henry, Guillaume, Thibault
Publikováno v:
J Cell Sci
Lipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat storage-inducing transmembrane (FIT; also known as FITM) family induces LD formation. Here, we establish a model system to study the role of the Saccharomyc
Autor:
William A. Prinz, Charlie Marvalim, Peter Shyu, Stephen A. Jesch, Susan A. Henry, Wei Sheng Yap, Maria L. Gaspar, Guillaume Thibault
Lipid droplets (LDs) have long been regarded as inert cytoplasmic organelles with the primary function of housing excess intracellular lipids. More recently, LDs have been strongly implicated in conditions of lipid and protein dysregulation. The fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdaf4bd39ae94fbb8e514b62c7b2c716
Autor:
Guillaume Thibault, Haoxi Wu, Wei Sheng Yap, Bhawana George, Jhee Hong Koh, Nurulain Ho, Shu Chen Chong, Stefan Taubert, Wilson Wen Bin Goh, Jiaming Xu
Publikováno v:
The Journal of Cell Biology
Ho et al. identified pathways, beyond lipid metabolism, that are required to maintain ER integrity and, when disrupted, activate the UPR by lipid bilayer stress through a sensor in Ire1. The resulting downstream transcriptional program differs from p
Autor:
Peter Shyu, Stephen A. Jesch, William A. Prinz, Susan A. Henry, Charlie Marvalim, Wei Sheng Yap, Maria L. Gaspar, Guillaume Thibault
Publikováno v:
Journal of Cell Science.
Lipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat storage inducing transmembrane (FIT) family induces LD formation. Here, we establish a model system to study the role of S. cerevisiae FIT homologues (ScFIT