Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Wei Shen Aik"'
Autor:
Ho Sing Lo, Kenrie Pui Yan Hui, Hei-Ming Lai, Xu He, Khadija Shahed Khan, Simranjeet Kaur, Junzhe Huang, Zhongqi Li, Anthony K. N. Chan, Hayley Hei-Yin Cheung, Ka-Chun Ng, John Chi Wang Ho, Yu Wai Chen, Bowen Ma, Peter Man-Hin Cheung, Donghyuk Shin, Kaidao Wang, Meng-Hsuan Lee, Barbara Selisko, Cecilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Kuen-Phon Wu, Po-Huang Liang, Ivan Dikic, Zhong Zuo, Francis K. L. Chan, David S. C. Hui, Vincent C. T. Mok, Kam-Bo Wong, Chris Ka Pun Mok, Ho Ko, Wei Shen Aik, Michael Chi Wai Chan, Wai-Lung Ng
Publikováno v:
ACS Central Science, Vol 7, Iss 5, Pp 792-802 (2021)
Externí odkaz:
https://doaj.org/article/c762182b6ed241e1a9a8500ceaadaf97
Autor:
Wei Shen Aik, Min-Han Lin, Dazhi Tan, Ashutosh Tripathy, William F Marzluff, Zbigniew Dominski, Chi-Yuan Chou, Liang Tong
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186034 (2017)
Unlike canonical pre-mRNAs, animal replication-dependent histone pre-mRNAs lack introns and are processed at the 3'-end by a mechanism distinct from cleavage and polyadenylation. They have a 3' stem loop and histone downstream element (HDE) that are
Externí odkaz:
https://doaj.org/article/c2c4338882554119875ed89043998e05
Autor:
Xiao-cui Yang, Anthony Desotell, Min-Han Lin, Andrew S. Paige, Agata Malinowska, Yadong Sun, Wei Shen Aik, Michał Dadlez, Liang Tong, Zbigniew Dominski
Publikováno v:
bioRxiv
U7 snRNP is a multi-subunit endonuclease required for 3’ end processing of metazoan replication-dependent histone pre-mRNAs. In contrast to the spliceosomal snRNPs, U7 snRNP lacks the Sm subunits D1 and D2 and instead contains two related proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099e3e87a1075660c2eebb25d2fc80a9
https://europepmc.org/articles/PMC10197641/
https://europepmc.org/articles/PMC10197641/
Publikováno v:
Nucleic Acids Research. 50:4148-4160
AlkB homologue 5 (ALKBH5) is a ferrous iron and 2-oxoglutarate dependent oxygenase that demethylates RNA N6-methyladenosine (m6A), a post-transcriptional RNA modification with an emerging set of regulatory roles. Along with the fat mass and obesity-a
Autor:
Afaf H. El-Sagheer, Ivanhoe K. H. Leung, Tom Brown, Michael A. McDonough, Anthony Tumber, Nok Yin Tam, Caitlin Clunie-O'Connor, Dong Zhang, Marina Demetriades, Shifali Shishodia, Wei Shen Aik, Thomas M. Leissing, Eidarus Salah, Pratheesh Maheswaran, Yi Min Ng, Christopher J. Schofield
Publikováno v:
Journal of Medicinal Chemistry
FTO catalyzes the Fe(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N6-methyladenosine (m6A) in mRNA. FTO is a proposed target for anti-cancer therapy. Using information from crystal structures of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639c2be01f207a01903964a703615f30
https://ora.ox.ac.uk/objects/uuid:839b007e-dd4b-4bc0-ac22-ed37a4bd5169
https://ora.ox.ac.uk/objects/uuid:839b007e-dd4b-4bc0-ac22-ed37a4bd5169
Publikováno v:
Methods Enzymol
Methods in Enzymology ISBN: 9780128235737
Methods in Enzymology ISBN: 9780128235737
In animal cells, replication-dependent histone pre-mRNAs are processed at the 3'-end by an endonucleolytic cleavage carried out by the U7 snRNP, a machinery that contains the U7 snRNA and many protein subunits. Studies on the composition of this mach
Autor:
Yue, Wu, Wing-Sze, Tam, Ho-Fai, Chau, Simranjeet, Kaur, Waygen, Thor, Wei Shen, Aik, Wai-Lun, Chan, Markus, Zweckstetter, Ka-Leung, Wong
Publikováno v:
Chemical Science
Traditional fluorescent peptide chemical syntheses hinge on the use of limited fluorescent/dye-taggable unnatural amino acids and entail multiple costly purifications. Here we describe a facile and efficient protocol for in situ construction of dipyr
Autor:
Anthony K. N. Chan, Bruno Canard, Kam-Bo Wong, John Chi Wang Ho, Po-Huang Liang, Kaidao Wang, David S.C. Hui, Kuen-Phon Wu, Junzhe Huang, Vincent Mok, Kenrie Pui Yan Hui, Barbara Selisko, Yu Wai Chen, Ho Sing Lo, Hayley Hei Yin Cheung, Khadija Shahed Khan, Cécilia Eydoux, Jean-Claude Guillemot, Chris Ka Pun Mok, Meng Hsuan Lee, Xu He, Ivan Dikic, Hei Ming Lai, Donghyuk Shin, Michael C. W. Chan, Francis K.L. Chan, Ka Chun Ng, Zhongqi Li, Wai-Lung Ng, Peter Man-Hin Cheung, Simranjeet Kaur, Bowen Ma, Wei Shen Aik, Zhong Zuo, Ho Ko
Publikováno v:
ACS Central Science
ACS Central Science, 2021, 7 (5), pp.792-802. ⟨10.1021/acscentsci.0c01186⟩
ACS Central Science, Vol 7, Iss 5, Pp 792-802 (2021)
ACS Central Science, 2021, 7 (5), pp.792-802. ⟨10.1021/acscentsci.0c01186⟩
ACS Central Science, Vol 7, Iss 5, Pp 792-802 (2021)
The outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global threat to human health. Using a multidisciplinary approach, we identified and validated the hepatitis C virus
Autor:
Junzhe Huang, Khadija Shahed Khan, Vincent Mok, Anthony K. N. Chan, Zhong Zuo, Ho Ko, Kenrie Pui Yan Hui, Michael C. W. Chan, Kam-Bo Wong, Francis K.L. Chan, Kaidao Wang, Hei-Ming Lai, Bruno Canard, David S.C. Hui, Donghyuk Shin, Kuen-Phon Wu, Ho Sing Lo, Meng-Hsuan Lee, Po-Huang Liang, Jean-Claude Guillemot, Wai-Lung Ng, Cécilia Eydoux, Peter Man-Hin Cheung, Barbara Selisko, Ka-Chun Ng, Ivan Dikic, Yu Wai Chen, Hayley Hei-Yin Cheung, Bowen Ma, Wei Shen Aik, Simranjeet Kaur, Zhongqi Li, John Chi Wang Ho
The outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global threat to human health. Using a multidisciplinary approach, we identified and validated the hepatitis C virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::869baad0a1ca58425a491e6cad7956a0
https://doi.org/10.1101/2020.05.26.116020
https://doi.org/10.1101/2020.05.26.116020
Publikováno v:
RNA
Metazoan replication-dependent histone pre-mRNAs are cleaved at the 3′ end by U7 snRNP, an RNA-guided endonuclease that contains U7 snRNA, seven proteins of the Sm ring, FLASH, and four polyadenylation factors: symplekin, CPSF73, CPSF100, and CstF6