Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Wei Hao Chen"'
Autor:
Yen‐Nien Liu, Wei‐Yu Chen, Ming‐Kun Liu, Hsiu‐Lien Yeh, Wei‐Hao Chen, Kuo‐Ching Jiang, Han‐Ru Li, Zi‐Qing Chen, Wan‐Hsin Wang, Wassim Abou‐Kheir, Yu‐Ching Wen
Publikováno v:
Molecular Oncology, Vol 18, Iss 6, Pp 1665-1686 (2024)
Prostate stromal cells play a crucial role in the promotion of tumor growth and immune evasion in the tumor microenvironment (TME) through intricate molecular alterations in their interaction with prostate cancer (PCa) cells. While the impact of thes
Externí odkaz:
https://doaj.org/article/6a3f0eafcbd34b4ea90358e88612bba9
Autor:
Ke Hung Tsui, Chien-Liang Liu, Hsiu-Lien Yeh, Ming-Kun Liu, Chien-Hsiu Li, Wei-Hao Chen, Kuo-Ching Jiang, Han-Ru Li, Phan Vu Thuy Dung, Michael Hsiao, Wassim Abou-Kheir, Yen-Nien Liu
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110562- (2024)
Summary: The interaction between prostate cancer (PCa) cells and prostate stromal cells fosters an immunosuppressive tumor microenvironment (TME) that promotes tumor growth and immune evasion. However, the specific signaling pathways involved remain
Externí odkaz:
https://doaj.org/article/b2660cab58d940baabbe7a276815442f
Mining Real-World Big Data to Characterize Adverse Drug Reaction Quantitatively: Mixed Methods Study
Publikováno v:
Journal of Medical Internet Research, Vol 26, p e48572 (2024)
BackgroundAdverse drug reactions (ADRs), which are the phenotypic manifestations of clinical drug toxicity in humans, are a major concern in precision clinical medicine. A comprehensive evaluation of ADRs is helpful for unbiased supervision of market
Externí odkaz:
https://doaj.org/article/c652678fdcb1423aa546508ee1a5082b
Autor:
Yu-Ching Wen, Van Thi Ngoc Tram, Wei-Hao Chen, Chien-Hsiu Li, Hsiu-Lien Yeh, Phan Vu Thuy Dung, Kuo-Ching Jiang, Han-Ru Li, Jiaoti Huang, Michael Hsiao, Wei-Yu Chen, Yen-Nien Liu
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-15 (2023)
Abstract Current treatment options for prostate cancer focus on targeting androgen receptor (AR) signaling. Inhibiting effects of AR may activate neuroendocrine differentiation and lineage plasticity pathways, thereby promoting the development of neu
Externí odkaz:
https://doaj.org/article/592d69a507654d59b898cc32c81f3e2b
Autor:
Wei-Yu Chen, Phan Vu Thuy Dung, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Han-Ru Li, Zi-Qing Chen, Michael Hsiao, Jiaoti Huang, Yu-Ching Wen, Yen-Nien Liu
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102686- (2023)
Conventional treatment of prostate cancer (PCa) uses androgen-deprivation therapy (ADT) to inhibit androgen receptor (AR) signaling-driven tumor progression. ADT-induced PCa recurrence may progress to an AR-negative phenotype with neuroendocrine (NE)
Externí odkaz:
https://doaj.org/article/ce24179a46364bfaa956e050217da070
Autor:
Yu-Ching Wen, Van Thi Ngoc Tram, Wei-Hao Chen, Chien-Hsiu Li, Hsiu-Lien Yeh, Phan Vu Thuy Dung, Kuo-Ching Jiang, Han-Ru Li, Jiaoti Huang, Michael Hsiao, Wei-Yu Chen, Yen-Nien Liu
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/02ec34929e6d45c8a7f5c70ba48e6eeb
Publikováno v:
Molecules, Vol 29, Iss 2, p 311 (2024)
Reactions of N,N′-bis(3-methylpyridyl)oxalamide (L1), N,N’-bis(3-methylpyridyl)adipoamide (L2) and N,N’-bis(3-methylpyridyl)sebacoamide (L3) with tricarboxylic acids and Cu(II) salts afforded {[Cu(L1)(1,3,5-HBTC)]·H2O}n (1,3,5-H3BTC = 1,3,5-be
Externí odkaz:
https://doaj.org/article/15aeca0912c841a0a86d793d46915a79
Autor:
Yu-Ching Wen, Wei-Yu Chen, Van Thi Ngoc Tram, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Wassim Abou-Kheir, Jiaoti Huang, Michael Hsiao, Yen-Nien Liu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-15 (2022)
Abstract Neuroendocrine differentiation (NED) frequently occurs in androgen-deprivation therapy (ADT)-resistant prostate cancer (PCa) and is typically associated with metabolic pathway alterations, acquisition of lineage plasticity, and malignancy. T
Externí odkaz:
https://doaj.org/article/e3a0aac4b04348a4bbdbcb006a370577
Autor:
Yu-Ching Wen, Yen-Nien Liu, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Shian-Ren Lin, Jiaoti Huang, Michael Hsiao, Wei-Yu Chen
Publikováno v:
Oncogenesis, Vol 10, Iss 11, Pp 1-11 (2021)
Abstract Neuroendocrine differentiation (NED) is associated with WNT signaling activation and can be significantly observed after failure of androgen-deprivation therapy (ADT) for prostatic adenocarcinomas. Cytokine signaling is stimulated in NED pro
Externí odkaz:
https://doaj.org/article/99d5960710964c0a90f14edae6b01add
Autor:
Wei-Yu Chen, Yu-Ching Wen, Shian-Ren Lin, Hsiu-Lien Yeh, Kuo-Ching Jiang, Wei-Hao Chen, Yow-Sien Lin, Qingfu Zhang, Phui-Ly Liew, Michael Hsiao, Jiaoti Huang, Yen-Nien Liu
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Here, the authors discover that NGF, upregulated by transcription factor ZBTB46 in prostate cancer exposed to androgen therapy, promotes neuroendocrine differentiation. They show that NGF interacts with the GPCR CHRM4, that both NGF and CHRM4 are upr
Externí odkaz:
https://doaj.org/article/e7b7c66702104de49414ef8b54df1488