Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast.

Autor: Wei-Chun Au, Tianyi Zhang, Prashant K Mishra, Jessica R Eisenstatt, Robert L Walker, Josefina Ocampo, Anthony Dawson, Jack Warren, Michael Costanzo, Anastasia Baryshnikova, Karin Flick, David J Clark, Paul S Meltzer, Richard E Baker, Chad Myers, Charles Boone, Peter Kaiser, Munira A Basrai

Publikováno v: PLoS Genetics, Vol 16, Iss 2, p e1008597 (2020)

Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cell

Externí odkaz: https://doaj.org/article/4a4e4d4931964e2b9c6fa1e904c0dd0e

Reduced gene dosage of histone H4 prevents CENP-A mislocalization and chromosomal instability in Saccharomyces cerevisiae

Autor: Evelyn Suva, Jessica R. Eisenstatt, Wei-Chun Au, Michael Costanzo, Kentaro Ohkuni, Munira A. Basrai, Olivia Preston, Charles Boone, Loran Gliford

Publikováno v: Genetics

Mislocalization of the centromeric histone H3 variant (Cse4 in budding yeast, CID in flies, CENP-A in humans) to noncentromeric regions contributes to chromosomal instability (CIN) in yeast, fly, and human cells. Overexpression and mislocalization of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbbc3c3e6fbddcdb5eeaf51a8bcb81b
https://doi.org/10.1093/genetics/iyab033

Dbf4-dependent kinase (DDK)-mediated proteolysis of CENP-A prevents mislocalization of CENP-A in Saccharomyces cerevisiae

Autor: Michael Weinreich, Lars Boeckmann, Richard Baker, Michael Costanzo, Anastasia Baryshnikova, Josefina Ocampo, Charles Boone, Levi Bursch, Chad L. Myers, Jessica R. Eisenstatt, David Clark, Munira A. Basrai, Valerie Garcia, Wei-Chun Au, Robert A. Sclafani

Publikováno v: G3: Genes, Genomes, Genetics, Vol 10, Iss 6, Pp 2057-2068 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61c9df8dc3c7a830058a84165e8d48a
https://www.g3journal.org/content/10/6/2057

Deposition of Centromeric Histone H3 Variant CENP-A/Cse4 into Chromatin Is Facilitated by Its C-Terminal Sumoylation

Autor: Evelyn Suva, Paul S. Meltzer, Robert L. Walker, Reuben Levy-Myers, Richard Baker, Kentaro Ohkuni, Wei-Chun Au, Munira A. Basrai

Publikováno v: Genetics

Centromeric localization of CENP-A (Cse4 in Saccharomyces cerevisiae, CID in flies, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of overexpressed CENP-A contributes to aneuploidy in yeast, flies, and humans, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b6ab9a54bd619843f9b0892f277300
https://europepmc.org/articles/PMC7153950/

N-terminal Sumoylation of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis To Prevent Mislocalization to Non-centromeric Chromatin

Autor: Richard Baker, Yoshimitsu Takahashi, Kentaro Ohkuni, Jack Warren, Reuben Levy-Myers, Wei-Chun Au, Munira A. Basrai

Publikováno v: G3: Genes|Genomes|Genetics

Stringent regulation of cellular levels of evolutionarily conserved centromeric histone H3 variant (CENP-A in humans, CID in flies, Cse4 in yeast) prevents its mislocalization to non-centromeric chromatin. Overexpression and mislocalization of CENP-A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4560b4c0839782648217118a2c76c41f
https://doi.org/10.1534/g3.117.300419