Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Wei Chou, Tseng"'
1
Akademický článek
Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2
Autor: Karsten Nalbach, Martina Schifferer, Debjani Bhattacharya, Hung Ho-Xuan, Wei Chou Tseng, Luis A. Williams, Alexandra Stolz, Stefan F. Lichtenthaler, Zvulun Elazar, Christian Behrends
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Hereditary sensory and autonomic neuropathy 9 (HSAN9) is a rare fatal neurological disease caused by mis- and nonsense mutations in the gene encoding for Tectonin β-propeller repeat containing protein 2 (TECPR2). While TECPR2 is required fo
Externí odkaz: https://doaj.org/article/6842faee2f4848b893cd13b63561bcca
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2
Akademický článek
Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models
Autor: Luis A. Williams, David J. Gerber, Amy Elder, Wei Chou Tseng, Valeriya Baru, Nathaniel Delaney-Busch, Christina Ambrosi, Gauri Mahimkar, Vaibhav Joshi, Himali Shah, Karthiayani Harikrishnan, Hansini Upadhyay, Sakthi H. Rajendran, Aishwarya Dhandapani, Joshua Meier, Steven J. Ryan, Caitlin Lewarch, Lauren Black, Julie Douville, Stefania Cinquino, Helen Legakis, Karsten Nalbach, Christian Behrends, Ai Sato, Lorenzo Galluzzi, Timothy W. Yu, Duncan Brown, Sudhir Agrawal, David Margulies, Alan Kopin, Graham T. Dempsey
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 189-203 (2022)
Mutations in the TECPR2 gene are the cause of an ultra-rare neurological disorder characterized by intellectual disability, impaired speech, motor delay, and hypotonia evolving to spasticity, central sleep apnea, and premature death (SPG49 or HSAN9;
Externí odkaz: https://doaj.org/article/555fd4156baf47509e8e7211947eb238
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4
Akademický článek
Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling
Autor: Wei Chou Tseng, Veronica Reinhart, Thomas A. Lanz, Mark L. Weber, Jincheng Pang, Kevin Xuong Vinh Le, Robert D. Bell, Patricio O’Donnell, Derek L. Buhl
Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Schizophrenia is a complex and heterogenous disease that presents with abnormalities in glutamate signaling and altered immune and inflammatory signals. Genome-wide association studies have indicated specific genes and pathways that may cont
Externí odkaz: https://doaj.org/article/78b4111fc55c48a39108af05d438929d
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6
Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling
Autor: Derek L. Buhl, Wei Chou Tseng, Veronica Reinhart, Mark L. Weber, Kevin Xuong Vinh Le, Jincheng Pang, Robert D. Bell, Patricio O'Donnell, Thomas A. Lanz
Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Schizophrenia is a complex and heterogenous disease that presents with abnormalities in glutamate signaling and altered immune and inflammatory signals. Genome-wide association studies have indicated specific genes and pathways that may contribute to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2619ad2223bbd4ca7735da010c02dc
https://doaj.org/article/78b4111fc55c48a39108af05d438929d
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8
TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype
Autor: Brett Antonio, Katrina E. Yoger, David C. Pryde, Aaron C. Gerlach, Seungil Han, Wei Chou Tseng, Veerabahu Shanmugasundaram, Karen M. Padilla
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 115(48)
TRPA1, a member of the transient receptor potential channel (TRP) family, is genetically linked to pain in humans, and small molecule inhibitors are efficacious in preclinical animal models of inflammatory pain. These findings have driven significant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c1b587c9dd507e3c86c4a6f003f363
https://pubmed.ncbi.nlm.nih.gov/30429323
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9
Pharmacological evaluation of clinically relevant concentrations of (2R,6R)-hydroxynorketamine
Autor: Jason K. Dutra, Christopher W. am Ende, Derek L. Buhl, Katherine Hales, Wei Chou Tseng, Dmitri Volfson, Jincheng Pang, Luke Joseph Bogart, Michael Eric Green, Mark L. Weber, Christopher L. Shaffer
Publikováno v: Neuropharmacology. 153
Ketamine is a rapid-onset antidepressant whose efficacy long outlasts its pharmacokinetics. Multiple studies suggest ketamine's antidepressant effects require increased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-dependent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c502f3fa5d2405c95b395e787902dd65
https://pubmed.ncbi.nlm.nih.gov/31015046
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10
Giant ankyrin-G: A critical innovation in vertebrate evolution of fast and integrated neuronal signaling
Autor: Paul M. Jenkins, Namsoo Kim, Wei Chou Tseng, Vann Bennett, Henry H. Yin, Steven L. Jones, Tatyana Svitkina
Publikováno v: Proceedings of the National Academy of Sciences. 112:957-964
Axon initial segments (AISs) and nodes of Ranvier are sites of clustering of voltage-gated sodium channels (VGSCs) in nervous systems of jawed vertebrates that facilitate fast long-distance electrical signaling. We demonstrate that proximal axonal po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a731d0010a012032920ced1a1d580d1e
https://doi.org/10.1073/pnas.1416544112
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