Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Wei–Jia Kong"'
Autor:
Yong Tao, Veronica Lamas, Wan Du, Wenliang Zhu, Yiran Li, Madelynn N. Whittaker, John A. Zuris, David B. Thompson, Arun Prabhu Rameshbabu, Yilai Shu, Xue Gao, Johnny H. Hu, Charles Pei, Wei-Jia Kong, Xuezhong Liu, Hao Wu, Benjamin P. Kleinstiver, David R. Liu, Zheng-Yi Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mutations in Atp2b2, an outer hair cell gene, cause dominant hearing loss in humans. Using a mouse model Atp2b2 Obl/+, with a dominant hearing loss mutation (Oblivion), we show that liposome-mediated in vivo delivery of CRISPR-Cas9 ribonucle
Externí odkaz:
https://doaj.org/article/a29936b8a683497cbbd1b953799336a4
Publikováno v:
Brazilian Journal of Otorhinolaryngology, Vol 88, Iss 6, Pp 925-931 (2022)
Introduction: High mobility group box 1 protein participates in the pathogenesis of allergic rhinitis. Activation of the inflammasome can mediate the release of high mobility group box 1. The role of the absent in melanoma 2 inflammasome in allergic
Externí odkaz:
https://doaj.org/article/b719479e9386425da73719926f120e39
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Cisplatin is widely used in clinical tumor chemotherapy but has severe ototoxic side effects, including tinnitus and hearing damage. This study aimed to determine the molecular mechanism underlying cisplatin-induced ototoxicity. In this study, we use
Externí odkaz:
https://doaj.org/article/25ef1aeadeba445c80e182de3c2c51c4
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Recent studies have revealed the significant role of the competing endogenous RNA (ceRNA) network in human diseases. However, systematic analysis of the ceRNA mechanism in chronic rhinosinusitis with nasal polyps (CRSwNP) is limited. In this
Externí odkaz:
https://doaj.org/article/97691a856bb34d66bd1729985acf5509
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Chronic inflammation may promote the incidence and development of neoplasms. As a pro-inflammatory death pathway, pyroptosis could induce normal cells to transform into cancerous cells, but the potential effect of pyroptosis in head and neck squamous
Externí odkaz:
https://doaj.org/article/43b9345cc52147c8abefc2b51fcaa6a4
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
BackgroundHearing impairment (HI), a highly prevalent sensory impairment affecting older adults, is a risk factor for cognitive decline. However, few studies examined the association between HI and all-cause mortality, and the role of different cogni
Externí odkaz:
https://doaj.org/article/5dcdc65669c448c6806fb409c3ebac2e
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundObservational studies have suggested that hearing impairment (HI) was associated with the risk of falls, but it remains unclear if this association is of causal nature.MethodsA two-sample Mendelian randomization (MR) study was conducted to
Externí odkaz:
https://doaj.org/article/4677567427454c21803155d79319657d
Autor:
Xiao-zhou Liu, Yuan Jin, Sen Chen, Kai Xu, Le Xie, Yue Qiu, Xiao-hui Wang, Yu Sun, Wei-jia Kong
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
Mutations in the GJB2 gene encoding connexin26 (Cx26) protein are one of the most common causes of hereditary deafness. Previous studies have found that different Cx26-null mouse models have severe hearing loss and deformity of the organ of Corti (OC
Externí odkaz:
https://doaj.org/article/1bfdc77929ba48c4a0515fc8205f9408
Publikováno v:
Frontiers in Public Health, Vol 9 (2021)
Introduction: Despite growing recognition of hearing loss as a risk factor for late life cognitive disorders, sex and gender analysis of this association has been limited. Elucidating this is one means to advocate for holistic medicine by considering
Externí odkaz:
https://doaj.org/article/27fcabf969fa4b62b10620d11f2a9443
Publikováno v:
Brain Sciences, Vol 12, Iss 11, p 1432 (2022)
(1) Background: Vestibular migraine (VM) and Menière’s disease (MD) share multiple features in terms of clinical presentations and auditory-vestibular functions, and, therefore, more accurate diagnostic tools to distinguish between the two disorde
Externí odkaz:
https://doaj.org/article/f6aba14f3cf145b89c1e0be2b9edf713