Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Wei‐Xing Shi"'
BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination
Autor:
Xiu-Xiu Liu, Xing-Hui Chen, Zhi-Wei Zheng, Qin Jiang, Chen Li, Lin Yang, Xiang Chen, Xing-Feng Mao, Hao-Yang Yuan, Li-Li Feng, Quan Jiang, Wei-Xing Shi, Takuya Sasaki, Kohji Fukunaga, Zhong Chen, Feng Han, Ying-Mei Lu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Cerebellar ataxias are characterized by a progressive decline in motor coordination, but the specific output circuits and underlying pathological mechanism remain poorly understood. Through cell-type-specific manipulations, we discovered a n
Externí odkaz:
https://doaj.org/article/7040bb88fa0149eea18a0a6f48fb8c9c
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 3, Pp n/a-n/a (2022)
Abstract The prolonged exposure to obesogenic diets disrupts the mesocortical dopaminergic input to the prefrontal cortex (PFC). This leads to suboptimal dopamine levels in this brain region, which affects cognition and control of food intake. Treatm
Externí odkaz:
https://doaj.org/article/6e04062eedc042c193d10331e53a7758
Autor:
Guofang Shen, Wei-Xing Shi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Cortical neurons oscillate between Up and Down states during slow wave sleep and general anesthesia. Recent studies show that Up/Down oscillations also occur during quiet wakefulness. Arousal eliminates Down states and transforms Up/Down oscillations
Externí odkaz:
https://doaj.org/article/03b440718b86410eaccfd0e29409f822
Autor:
Ling Xiao Shao, Ning He Sun, Qiao Zhen Chen, Yi Xuan Yin, Heng Yu Fan, Ying Mei Lu, Dong Mei Gong, Quan Jiang, Feng Han, Xiu Xiu Liu, Cheng Kun Wang, Chao Yu, Kohji Fukunaga, Zhong Chen, Gang Wu, Wei-Xing Shi
Publikováno v:
Molecular Psychiatry. 24:1461-1477
Anxiety disorders are the most prevalent psychiatric disorders, but their pathogenic mechanism remains poorly understood. Here, we report that transmembrane protein 74 (TMEM74), which contains two putative transmembrane domains and exhibits high leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9249b34501e7a3afba9598f3f5af934a
https://doi.org/10.1038/s41380-019-0402-8
https://doi.org/10.1038/s41380-019-0402-8
Autor:
Ying Mei Lu, Ling Juan Hong, Ning He Sun, Dan Yang Chen, Li-Li Feng, Kohji Fukunaga, Feng Han, Wei-Xing Shi, Zhong Chen, Tian-tian Cui, Xing Hui Chen, Shuai Shuai Wang, Cheng Kun Wang, Ya Ping Lu
Publikováno v:
Theranostics
Prolonged occlusion of multiple microvessels causes microvascular injury. G protein-coupled receptor 124 (GPR124) has been reported to be required for maintaining central nervous system (CNS) angiogenesis and blood-brain barrier integrity. However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f601f9bdf218a42e405a64ff3614fe3
https://doi.org/10.7150/thno.34168
https://doi.org/10.7150/thno.34168
Publikováno v:
Pharmacology Research & Perspectives; Jun2022, Vol. 10 Issue 3, p1-5, 5p
Publikováno v:
European journal of pharmacology. 892
Finding alternative treatments for attention-deficit/hyperactivity disorder (ADHD) is crucial given the safety and efficacy problems of current ADHD medications. Droxidopa, also known as L-threo-dihydroxyphenylserine (L-DOPS), is a norepinephrine pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de906f486147a29c4bfe211ca242c67e
https://pubmed.ncbi.nlm.nih.gov/33347825
https://pubmed.ncbi.nlm.nih.gov/33347825
Publikováno v:
Neuropharmacology. 131:431-439
Amphetamine-like psychostimulants, including methylphenidate, have been shown to produce two opposing effects on dopamine (DA) neurons: a DA receptor-mediated feedback inhibition and a non-DA receptor-mediated excitation. To test whether the latter e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ab54b764ed15597f82504ed83fe615
https://doi.org/10.1016/j.neuropharm.2018.01.015
https://doi.org/10.1016/j.neuropharm.2018.01.015
Autor:
Wei-Xing Shi, Guofang Shen
Publikováno v:
Addiction biologyREFERENCES. 26(1)
Cortical neurons oscillate synchronously between the Up and Down state during slow-wave sleep and general anesthesia. Using local-field-potential recording in the rat prefrontal cortex (PFC), we have shown that systemic administration of methylphenid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec3ed1738b33c62f5aed198592a9c1a
https://pubmed.ncbi.nlm.nih.gov/32003119
https://pubmed.ncbi.nlm.nih.gov/32003119
Autor:
Ike dela Peña, Wei-Xing Shi
Publikováno v:
Medical Hypotheses. 93:113-116
Clinical evidence suggests that the prefrontal cortex (PFC) is hypofunctional in disorders including schizophrenia, drug addiction, and attention-deficit/hyperactivity disorder (ADHD). In schizophrenia, hypofrontality has been further suggested to ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6f0943b006f7dbcb40aa6149d060b5
https://doi.org/10.1016/j.mehy.2016.05.032
https://doi.org/10.1016/j.mehy.2016.05.032