Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Wei‐Lun Hwang"'
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Background The tumour microenvironment (TME) is a specialised niche involving intercellular communication among cancer cells and various host cells. Among the host cells, the quantity and quality of immune cells within the TME play essential
Externí odkaz:
https://doaj.org/article/e257c61d58b444f9a0a555b550819d20
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T cells play a crucial role in the regulation of immune response and are integral to the efficacy of cancer immunotherapy. Because immunotherapy has emerged as a promising treatment for cancer, increasing attention has been focused on the differentia
Externí odkaz:
https://doaj.org/article/10a0eebc62d144d19788c7d900392e4d
Autor:
Heng-Huan Lee, Ying-Nai Wang, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Yu-Han Wang, Zhou Jiang, Shouping Xu, Jun Yao, Yufan Qiu, Yi-Hsin Hsu, Wei-Lun Hwang, Meisi Yan, Jong-Ho Cha, Jennifer L. Hsu, Jia Shen, Yuanqing Ye, Xifeng Wu, Ming-Feng Hou, Lin-Ming Tseng, Shao-Chun Wang, Mei-Ren Pan, Chin-Hua Yang, Yuan-Liang Wang, Hirohito Yamaguchi, Da Pang, Gabriel N. Hortobagyi, Dihua Yu, Mien-Chie Hung
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tum
Externí odkaz:
https://doaj.org/article/951d591c8f644e74b61e110feda5e096
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-17 (2019)
Abstract Background Cell-cell interactions maintain tissue homeostasis and contribute to dynamic alteration of the tumor microenvironment (TME). Communication between cancer and host cells not only promotes advanced disease aggression but also determ
Externí odkaz:
https://doaj.org/article/8d04323642934f89aa9bd4ae2927fa3d
Autor:
Chih-Chan Lee, Jiunn-Chang Lin, Wei-Lun Hwang, Ying-Ju Kuo, Hung-Kai Chen, Shyh-Kuan Tai, Chun-Chi Lin, Muh-Hwa Yang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Tumor microenvironment varies between primary and metastatic sites. Here they report tumor-associated macrophages from metastatic sites to be predominantly M2 type, and secrete IL-35 to promote metastasis through activation of JAK2–STAT6–GATA3 si
Externí odkaz:
https://doaj.org/article/cec4741886e6453981505003b003d69a
Autor:
Yih-Hsin Chang, Hui-Ju Yang, Huan-Wen Chen, Chiao-Wan Hsiao, Yi-Chen Hsieh, Yu-Wei Chan, Shu-Wen Chang, Wei-Lun Hwang, Wei-Shone Chen, Hou-Hsuan Cheng, Teh-Ying Chou, Fu-Pang Chang, Hsiang-Ling Ho, Fang-Yeh Chu, Yu-Li Lo, Chun-Jung Chen, Hui-Fang Tsai, Ming-Yuh Shiau
Publikováno v:
Cells, Vol 11, Iss 4, p 727 (2022)
Background: Common demographic risk factors are identified in colorectal cancer (CRC) and type 2 diabetes mellitus (DM), nevertheless, the molecular link and mechanism for CRC-DM comorbidity remain elusive. Dysregulated glycogen synthase kinase-3 bet
Externí odkaz:
https://doaj.org/article/62d7ba1ee1a041a7b60b37d6922eca8e
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6829 (2021)
Orbital fibrosis, a hallmark of tissue remodeling in Graves’ ophthalmopathy (GO), is a chronic, progressive orbitopathy with few effective treatments. Orbital fibroblasts are effector cells, and transforming growth factor β1 (TGF-β1) acts as a cr
Externí odkaz:
https://doaj.org/article/e1dbc459ef874502aab47aa71a693292
Autor:
Hung-Ming Chen, Chun-Chi Lin, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Shih-Ching Chang, Ching-Liang Ho, Chung-Chi Yang, Shih-Ching Huang, Yee Chao, Tsai-Tsen Liao, Wei-Lun Hwang, Hao-Wei Teng
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6940 (2021)
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an RNA-binding protein and serves as a post-transcriptional fine-tuner regulating the expression of mRNA targets. However, the clinicopathological roles of IGF2BP1 in colorectal cancer
Externí odkaz:
https://doaj.org/article/b95a9679f6de481f8ab18e05be401bef
Publikováno v:
Cancers, Vol 13, Iss 7, p 1742 (2021)
Head and neck squamous cell carcinomas (HNSCCs) are epithelial malignancies with 5-year overall survival rates of approximately 40–50%. Emerging evidence indicates that a small population of cells in HNSCC patients, named cancer stem cells (CSCs),
Externí odkaz:
https://doaj.org/article/025ecc3fb49e40f090ef6d6cbc4daa1e
Autor:
Tsai-Tsen Liao, Wei-Chung Cheng, Chih-Yung Yang, Yin-Quan Chen, Shu-Han Su, Tzu-Yu Yeh, Hsin-Yi Lan, Chih-Chan Lee, Hung-Hsin Lin, Chun-Chi Lin, Ruey-Hwa Lu, Arthur Er-Terg Chiou, Jeng-Kai Jiang, Wei-Lun Hwang
Publikováno v:
Cancers, Vol 13, Iss 8, p 1833 (2021)
Cell migration is critical for regional dissemination and distal metastasis of cancer cells, which remain the major causes of poor prognosis and death in patients with colorectal cancer (CRC). Although cytoskeletal dynamics and cellular deformability
Externí odkaz:
https://doaj.org/article/62afbbad05674a51a7eb1df25085df35