Transcriptional brain networks and their key regulators across the human lifespan

Autor: Wehrspaun, C

The human brain’s transcriptome undergoes substantial changes over the lifespan and shows characteristic patterns that reflect anatomical regions and cellular compositions. In this thesis, I applied combinations of network algorithms and tools from

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https://ora.ox.ac.uk/objects/uuid:8f6e0ce4-86ea-4034-ad16-753edb7717de

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Transcriptional brain networks and their key regulators across the human lifespan

Autor: Wehrspaun, Claudia Constanze

The human brain’s transcriptome undergoes substantial changes over the lifespan and shows characteristic patterns that reflect anatomical regions and cellular compositions. In this thesis, I applied combinations of network algorithms and tools from

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669760

Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy.

Autor: Nissim L; Synthetic Biology Group, Research Laboratory of Electronics , Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Wu MR; Synthetic Biology Group, Research Laboratory of Electronics , Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Pery E; Synthetic Biology Group, Research Laboratory of Electronics , Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Binder-Nissim A; Synthetic Biology Group, Research Laboratory of Electronics , Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Suzuki HI; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Stupp D; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, and Hadassah Medical School, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel., Wehrspaun C; Synthetic Biology Group, Research Laboratory of Electronics , Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Tabach Y; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, and Hadassah Medical School, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel., Sharp PA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Lu TK; Synthetic Biology Group, Research Laboratory of Electronics , Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science , Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Biophysics Program, Harvard University, Boston, MA 02115, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: timlu@mit.edu.

Publikováno v: Cell [Cell] 2017 Nov 16; Vol. 171 (5), pp. 1138-1150.e15. Date of Electronic Publication: 2017 Oct 19.