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Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation.

Autor: Smith JS; Department of Biochemistry, Duke University, Durham, NC 27710, USA.; Department of Medicine, Duke University, Durham, NC 27710, USA., Nicholson LT; Department of Medicine, Duke University, Durham, NC 27710, USA., Suwanpradid J; Department of Dermatology, Duke University, Durham, NC 27710, USA., Glenn RA; Department of Biochemistry, Duke University, Durham, NC 27710, USA., Knape NM; Department of Biochemistry, Duke University, Durham, NC 27710, USA., Alagesan P; Department of Biochemistry, Duke University, Durham, NC 27710, USA., Gundry JN; Department of Biochemistry, Duke University, Durham, NC 27710, USA., Wehrman TS; Primity Bio, Fremont, CA 94538, USA., Atwater AR; Department of Dermatology, Duke University, Durham, NC 27710, USA., Gunn MD; Department of Medicine, Duke University, Durham, NC 27710, USA.; Department of Immunology, Duke University, Durham, NC 27710, USA., MacLeod AS; Department of Dermatology, Duke University, Durham, NC 27710, USA.; Department of Immunology, Duke University, Durham, NC 27710, USA., Rajagopal S; Department of Biochemistry, Duke University, Durham, NC 27710, USA. sudarshan.rajagopal@dm.duke.edu.; Department of Medicine, Duke University, Durham, NC 27710, USA.

Publikováno v: Science signaling [Sci Signal] 2018 Nov 06; Vol. 11 (555). Date of Electronic Publication: 2018 Nov 06.

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.

Autor: Ho CCM; Department of Bioengineering, Stanford University School of Engineering, 443 Via Ortega, Stanford, CA 94305, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA., Chhabra A; Department of Blood and Marrow Transplantation, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA., Starkl P; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria., Schnorr PJ; Department of Blood and Marrow Transplantation, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA., Wilmes S; Department of Biology, University of Osnabruck, Barbarastr. 11, 49076 Osnabruck, Germany., Moraga I; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA., Kwon HS; Department of Blood and Marrow Transplantation, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA., Gaudenzio N; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA., Sibilano R; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA., Wehrman TS; Primity Bio, 48383 Fremont Blvd, Suite 118, Fremont, CA 94538, USA., Gakovic M; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA., Sockolosky JT; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA., Tiffany MR; Department of Pediatrics and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA., Ring AM; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA., Piehler J; Department of Biology, University of Osnabruck, Barbarastr. 11, 49076 Osnabruck, Germany., Weissman IL; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA; Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA., Galli SJ; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA., Shizuru JA; Department of Blood and Marrow Transplantation, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA., Garcia KC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA. Electronic address: kcgarcia@stanford.edu.

Publikováno v: Cell [Cell] 2017 Mar 09; Vol. 168 (6), pp. 1041-1052.e18.

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.

Autor: Moraga I; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5345, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5345, USA., Wernig G; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305-5345, USA; Department of Pathology, Division of Hematopathology, Stanford University School of Medicine, Stanford, CA 94305-5345, USA., Wilmes S; Division of Biophysics, Department of Biology, University of Osnabrück, 49076 Osnabrück, Germany., Gryshkova V; Ludwig Institute for Cancer Research and de Duve Institute, Université catholique de Louvain, 1200 Brussels, Belgium., Richter CP; Division of Biophysics, Department of Biology, University of Osnabrück, 49076 Osnabrück, Germany., Hong WJ; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305-5345, USA; Department of Internal Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305-5345, USA., Sinha R; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305-5345, USA., Guo F; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5345, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5345, USA., Fabionar H; DiscoveRx, 42501 Albrae Street, Fremont, CA 94538, USA., Wehrman TS; Primity Bio, 3350 Scott Boulevard, Suite 6101, Santa Clara, CA 95054, USA., Krutzik P; Primity Bio, 3350 Scott Boulevard, Suite 6101, Santa Clara, CA 95054, USA., Demharter S; Department of Computational Biology, Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK., Plo I; Institut Gustave Roussy, INSERM U1009, 94805 Villejuif, France., Weissman IL; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305-5345, USA., Minary P; Department of Computational Biology, Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK., Majeti R; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305-5345, USA; Department of Internal Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305-5345, USA., Constantinescu SN; Ludwig Institute for Cancer Research and de Duve Institute, Université catholique de Louvain, 1200 Brussels, Belgium., Piehler J; Division of Biophysics, Department of Biology, University of Osnabrück, 49076 Osnabrück, Germany., Garcia KC; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5345, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5345, USA. Electronic address: kcgarcia@stanford.edu.

Publikováno v: Cell [Cell] 2015 Mar 12; Vol. 160 (6), pp. 1196-208. Date of Electronic Publication: 2015 Feb 26.