Development of a self-limiting model of methotrexate-induced mucositis reinforces butyrate as a potential therapy

Autor: da Silva Ferreira, A R, van der Aa, S A J, Wehkamp, T, Wardill, H R, Ten Klooster, J P, Garssen, J, Harthoorn, L F, Hartog, A, Harmsen, H J M, Tissing, W J E, van Bergenhenegouwen, J, Afd Pharmacology, Pharmacology

Publikováno v: Scientific Reports, 11(1), 1. NLM (Medline)
Scientific Reports
Scientific Reports, 11:22911. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific reports

Background: Gastrointestinal mucositis remains a significant complication of anticancer treatment, with limited anti-mucositis interventions. Currently, there are few validated in vitro systems suitable to study the mechanisms of mucosal injury. Ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f0be1bb49864df41a96eba18f87645
https://dspace.library.uu.nl/handle/1874/419704

Development of a self-limiting model of methotrexate-induced mucositis reinforces butyrate as a potential therapy.

Autor: da Silva Ferreira AR; Department of Medical Microbiology and Infection prevention, University of Groningen, University Medical Center Groningen, Hanzeplein 1 EB80, 9713 GZ, Groningen, The Netherlands.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands., van der Aa SAJ; Department of Pediatric Oncology, University of Groningen, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands.; Danone Nutricia Research, Utrecht, The Netherlands.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands., Wehkamp T; Danone Nutricia Research, Utrecht, The Netherlands.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands., Wardill HR; Department of Pediatric Oncology, University of Groningen, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands.; Adelaide Medical School, The University of Adelaide, Adelaide, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands., Ten Klooster JP; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands., Garssen J; Danone Nutricia Research, Utrecht, The Netherlands.; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands., Harthoorn LF; Danone Nutricia Research, Utrecht, The Netherlands.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands., Hartog A; Danone Nutricia Research, Utrecht, The Netherlands.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands., Harmsen HJM; Department of Medical Microbiology and Infection prevention, University of Groningen, University Medical Center Groningen, Hanzeplein 1 EB80, 9713 GZ, Groningen, The Netherlands. h.j.m.harmsen@umcg.nl.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands. h.j.m.harmsen@umcg.nl., Tissing WJE; Department of Pediatric Oncology, University of Groningen, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands.; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands., van Bergenhenegouwen J; Danone Nutricia Research, Utrecht, The Netherlands.; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Research Centre for Healthy and Sustainable Living, Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences, Utrecht, The Netherlands.

Publikováno v: Scientific reports [Sci Rep] 2021 Nov 25; Vol. 11 (1), pp. 22911. Date of Electronic Publication: 2021 Nov 25.

A Fermented Milk Matrix Containing Postbiotics Supports Th1- and Th17-Type Immunity In Vitro and Modulates the Influenza-Specific Vaccination Response In Vivo in Association with Altered Serum Galectin Ratios.

Autor: Ayechu-Muruzabal V; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Xiao L; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Wehkamp T; Danone Nutricia Research, 3584 CT Utrecht, The Netherlands., van Ark I; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Hoogendoorn EJ; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Leusink-Muis T; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Folkerts G; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Garssen J; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.; Danone Nutricia Research, 3584 CT Utrecht, The Netherlands., Willemsen LEM; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Van't Land B; Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.; Center for Translational Immunology, The Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.

Publikováno v: Vaccines [Vaccines (Basel)] 2021 Mar 13; Vol. 9 (3). Date of Electronic Publication: 2021 Mar 13.

Dietary Vitamin D Supplementation Is Ineffective in Preventing Murine Cow's Milk Allergy, Irrespective of the Presence of Nondigestible Oligosaccharides.

Autor: Kerperien J; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Veening-Griffioen D; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Nutricia Research B.V, Utrecht, The Netherlands., Oja A; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Wehkamp T; Nutricia Research B.V, Utrecht, The Netherlands., Jeurink PV; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Nutricia Research B.V, Utrecht, The Netherlands., Garssen J; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Nutricia Research B.V, Utrecht, The Netherlands., Knippels LMJ; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Nutricia Research B.V, Utrecht, The Netherlands., Willemsen LEM; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands, L.E.M.Willemsen@uu.nl.

Publikováno v: International archives of allergy and immunology [Int Arch Allergy Immunol] 2020; Vol. 181 (12), pp. 908-918. Date of Electronic Publication: 2020 Aug 19.

IL-10 Receptor or TGF-β Neutralization Abrogates the Protective Effect of a Specific Nondigestible Oligosaccharide Mixture in Cow-Milk-Allergic Mice.

Autor: Kerperien J; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., Veening-Griffioen D; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., Wehkamp T; Nutricia Research BV, Utrecht, Netherlands., van Esch BCAM; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., Hofman GA; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., Cornelissen P; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., Boon L; Bioceros BV, Utrecht, Netherlands., Jeurink PV; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., Garssen J; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., Knippels LMJ; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., Willemsen LEM; Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.

Publikováno v: The Journal of nutrition [J Nutr] 2018 Aug 01; Vol. 148 (8), pp. 1372-1379.