CBX7 inhibitors affect H3K9 methyltransferase-regulated gene repression in leukemic cells.

Autor: de Groot AP; European Research Institute for Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, The Netherlands; Department of Hematopoiesis, Sanquin Research, Amsterdam, The Netherlands., Nguyen H; European Research Institute for Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, The Netherlands., Pouw JS; Department of Hematopoiesis, Sanquin Research, Amsterdam, The Netherlands., Weersing E; European Research Institute for Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, The Netherlands., Dethmers-Ausema A; European Research Institute for Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, The Netherlands., de Haan G; European Research Institute for Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, The Netherlands; Department of Hematopoiesis, Sanquin Research, Amsterdam, The Netherlands; Landsteiner Laboratory, Cancer Center Amsterdam, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands. Electronic address: G.deHaan@sanquin.nl.

Publikováno v: Experimental hematology [Exp Hematol] 2024 Nov 27, pp. 104691. Date of Electronic Publication: 2024 Nov 27.

3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice

Autor: Guerrero A, Innes AJ, Roux PF, Buisman SC, Jung J, Ortet L, Moiseeva V, Wagner V, Robinson L, Ausema A, Potapova A, Perdiguero E, Weersing E, Aarts M, Martin N, Wuestefeld T, Muñoz-Cánoves P, de Haan G, Bischof O, Gil J.

Publikováno v: Nature Aging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::a9a6470d847b2c11cc52193177a2a39c

Persistent expression of microRNA-125a targets is required to induce murine hematopoietic stem cell repopulating activity.

Autor: Luinenburg DG; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Dinitzen AB; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Flohr Svendsen A; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Cengiz R; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Ausema A; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Weersing E; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Bystrykh L; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., de Haan G; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: g.de.haan@umcg.nl.

Publikováno v: Experimental hematology [Exp Hematol] 2021 Feb; Vol. 94, pp. 47-59.e5. Date of Electronic Publication: 2020 Dec 15.

Correction: Quantitative distribution of patient-derived leukemia clones in murine xenografts revealed by cellular barcodes.

Autor: Jacobs S; Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands., Ausema A; Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands., Zwart E; Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands., Weersing E; Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands., Kingma MJ; Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands., El Menshawi YAS; Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands., de Haan G; Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands., Bystrykh LV; Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands., Belderbos ME; Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands. m.e.belderbos@prinsesmaximacentrum.nl.; Oncode Institute and Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. m.e.belderbos@prinsesmaximacentrum.nl.

Publikováno v: Leukemia [Leukemia] 2020 Jul; Vol. 34 (7), pp. 1974.

Donor-to-Donor Heterogeneity in the Clonal Dynamics of Transplanted Human Cord Blood Stem Cells in Murine Xenografts.

Autor: Belderbos ME; Department of Stem Cell Biology and Ageing, European Research Institute for the Biology of Ageing, University of Groningen, Groningen, Netherlands; Princess Máxima Center for Pediatric Oncology and Oncode Institute, Utrecht, Netherlands. Electronic address: m.e.belderbos@prinsesmaximacentrum.nl., Jacobs S; Department of Stem Cell Biology and Ageing, European Research Institute for the Biology of Ageing, University of Groningen, Groningen, Netherlands., Koster TK; Department of Stem Cell Biology and Ageing, European Research Institute for the Biology of Ageing, University of Groningen, Groningen, Netherlands., Ausema A; Department of Stem Cell Biology and Ageing, European Research Institute for the Biology of Ageing, University of Groningen, Groningen, Netherlands., Weersing E; Department of Stem Cell Biology and Ageing, European Research Institute for the Biology of Ageing, University of Groningen, Groningen, Netherlands., Zwart E; Department of Stem Cell Biology and Ageing, European Research Institute for the Biology of Ageing, University of Groningen, Groningen, Netherlands., de Haan G; Department of Stem Cell Biology and Ageing, European Research Institute for the Biology of Ageing, University of Groningen, Groningen, Netherlands., Bystrykh LV; Department of Stem Cell Biology and Ageing, European Research Institute for the Biology of Ageing, University of Groningen, Groningen, Netherlands.

Publikováno v: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [Biol Blood Marrow Transplant] 2020 Jan; Vol. 26 (1), pp. 16-25. Date of Electronic Publication: 2019 Sep 05.