Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements.

Autor: Simm C; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton, Victoria, Australia., Lee T-H; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Weerasinghe H; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton, Victoria, Australia., Walsh D; School of Life Sciences, University of Warwick, Coventry, United Kingdom., Nakou IT; Department of Chemistry, University of Warwick, Coventry, United Kingdom., Shankar M; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton, Victoria, Australia., Tse WC; School of Medicine, Monash University, Clayton, Victoria, Australia., Zhang Y; Department of Chemistry, University of Warwick, Coventry, United Kingdom., Inman R; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom., Mulder RJ; CSIRO Manufacturing, Research Way, Clayton, Victoria, Australia., Harrison F; School of Life Sciences, University of Warwick, Coventry, United Kingdom., Aguilar M-I; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Challis GL; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Department of Chemistry, University of Warwick, Coventry, United Kingdom.; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Monash University, Clayton, Victoria, Australia., Traven A; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton, Victoria, Australia.

Publikováno v: MBio [mBio] 2024 Nov 13; Vol. 15 (11), pp. e0261124. Date of Electronic Publication: 2024 Oct 18.

Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems.

Autor: Weerasinghe H; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton, Victoria, Australia., Stölting H; Department of Biochemistry and Molecular Biology and the Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Rose AJ; Department of Biochemistry and Molecular Biology and the Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Traven A; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton, Victoria, Australia.

Publikováno v: Microbiology and molecular biology reviews : MMBR [Microbiol Mol Biol Rev] 2024 Sep 26; Vol. 88 (3), pp. e0017122. Date of Electronic Publication: 2024 Sep 04.

The C-terminal protein interaction domain of the chromatin reader Yaf9 is critical for pathogenesis of Candida albicans .

Autor: Lo TL; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Clayton, Australia., Wang Q; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia., Nickson J; Centre to Impact AMR, Monash University, Clayton, Australia., van Denderen BJW; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Clayton, Australia., Deveson Lucas D; Genomics and Bioinformatics Platform, Monash University, Clayton, Australia., Chai HX; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia., Knott GJ; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia., Weerasinghe H; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Clayton, Australia., Traven A; Department of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Clayton, Australia.

Publikováno v: MSphere [mSphere] 2024 Mar 26; Vol. 9 (3), pp. e0069623. Date of Electronic Publication: 2024 Feb 20.

The short-chain fatty acid crotonate reduces invasive growth and immune escape of Candida albicans by regulating hyphal gene expression.

Autor: McCrory C; Department of Biochemistry and Molecular Biology and Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Clayton, Australia., Verma J; Department of Biochemistry and Molecular Biology and Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia., Tucey TM; Department of Biochemistry and Molecular Biology and Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia., Turner R; Department of Biochemistry and Molecular Biology and Stem Cells and Development Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia., Weerasinghe H; Department of Biochemistry and Molecular Biology and Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Clayton, Australia., Beilharz TH; Department of Biochemistry and Molecular Biology and Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.; Department of Biochemistry and Molecular Biology and Stem Cells and Development Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia., Traven A; Department of Biochemistry and Molecular Biology and Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia.; Centre to Impact AMR, Monash University, Clayton, Australia.

Publikováno v: MBio [mBio] 2023 Dec 19; Vol. 14 (6), pp. e0260523. Date of Electronic Publication: 2023 Nov 06.

Leveraging the MMV Pathogen Box to Engineer an Antifungal Compound with Improved Efficacy and Selectivity against Candida auris .

Autor: Pan B; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, VIC, Australia., Weerasinghe H; Infection Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, VIC, Australia., Sezmis A; School of Biological Sciences, Monash University, Clayton 3800, VIC, Australia., McDonald MJ; Centre to Impact AMR, Monash University, Clayton 3800, VIC, Australia.; School of Biological Sciences, Monash University, Clayton 3800, VIC, Australia., Traven A; Infection Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, VIC, Australia., Thompson P; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, VIC, Australia., Simm C; Infection Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, VIC, Australia.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2023 Oct 13; Vol. 9 (10), pp. 1901-1917. Date of Electronic Publication: 2023 Sep 27.