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Methods for detection of cardiac glycogen-autophagy.

Autor: Koutsifeli P, Daniels LJ, Neale J, Fong S, Varma U, Annandale M, Li X, Nursalim Y, Bell JR, Weeks KL, Stotland A, Taylor DJ, Gottlieb RA, Delbridge LMD, Mellor KM

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 11. Date of Electronic Publication: 2024 Aug 11.

Maternal Diet and Gut Microbiota Influence Predisposition to Cardiovascular Disease in Offspring.

Autor: Jama HA; Hypertension Research Laboratory, School of Biological Sciences (H.A.J., E.D., M.N., M.R.P., F.Z.M.), Monash University, Melbourne, Victoria, Australia.; Heart Failure Research Group (H.A.J., W.A.S., D.M.K., F.Z.M.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Dona MSI; Cardiac Cellular Systems (M.S.I.D., C.K., C.D.C., G.E.F., A.R.P.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Dinakis E; Hypertension Research Laboratory, School of Biological Sciences (H.A.J., E.D., M.N., M.R.P., F.Z.M.), Monash University, Melbourne, Victoria, Australia., Nakai M; Hypertension Research Laboratory, School of Biological Sciences (H.A.J., E.D., M.N., M.R.P., F.Z.M.), Monash University, Melbourne, Victoria, Australia., Paterson MR; Hypertension Research Laboratory, School of Biological Sciences (H.A.J., E.D., M.N., M.R.P., F.Z.M.), Monash University, Melbourne, Victoria, Australia., Shihata WA; Heart Failure Research Group (H.A.J., W.A.S., D.M.K., F.Z.M.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Krstevski C; Cardiac Cellular Systems (M.S.I.D., C.K., C.D.C., G.E.F., A.R.P.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Centre for Cardiovascular Biology and Disease Research (C.K., C.D.C., A.R.P.), La Trobe University, Melbourne, Victoria, Australia., Cohen CD; Cardiac Cellular Systems (M.S.I.D., C.K., C.D.C., G.E.F., A.R.P.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Centre for Cardiovascular Biology and Disease Research (C.K., C.D.C., A.R.P.), La Trobe University, Melbourne, Victoria, Australia., Weeks KL; Department of Anatomy and Physiology (K.L.W.), The University of Melbourne, Parkville, Victoria, Australia.; Baker Department of Cardiometabolic Health (K.L.W., D.G.D., H. Kiriazis, H. Kaipananickal, J.O., A.E.-O.), The University of Melbourne, Parkville, Victoria, Australia., Farrugia GE; Cardiac Cellular Systems (M.S.I.D., C.K., C.D.C., G.E.F., A.R.P.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Johnson C; Monash Micro Imaging (C.J.), Monash University, Melbourne, Victoria, Australia.; La Trobe Institute of Molecular Science (C.J.), La Trobe University, Melbourne, Victoria, Australia.; Burnet Institute, Melbourne, Victoria, Australia (C.J.)., Salimova E; Monash Biomedical Imaging (E.S.), Monash University, Melbourne, Victoria, Australia., Donner DG; School of Translational Medicine, Faculty of Medicine Nursing and Health Sciences (D.G.D., D.M.K.), Monash University, Melbourne, Victoria, Australia.; Preclinical Cardiology, Microsurgery and Imaging Platform (D.D., H. Kiriazis), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health (K.L.W., D.G.D., H. Kiriazis, H. Kaipananickal, J.O., A.E.-O.), The University of Melbourne, Parkville, Victoria, Australia.; Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.G.D., D.M.K.)., Kiriazis H; Preclinical Cardiology, Microsurgery and Imaging Platform (D.D., H. Kiriazis), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health (K.L.W., D.G.D., H. Kiriazis, H. Kaipananickal, J.O., A.E.-O.), The University of Melbourne, Parkville, Victoria, Australia., Kaipananickal H; Epigenetics in Human Health and Disease, Department of Diabetes, Central Clinical School, Alfred Centre (H. Kaipananickal, J.O., A.E.-O.), Monash University, Melbourne, Victoria, Australia.; Epigenetics in Human Health and Disease (H. Kaipananickal, J.O., A.E.-O.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health (K.L.W., D.G.D., H. Kiriazis, H. Kaipananickal, J.O., A.E.-O.), The University of Melbourne, Parkville, Victoria, Australia., Okabe J; Epigenetics in Human Health and Disease, Department of Diabetes, Central Clinical School, Alfred Centre (H. Kaipananickal, J.O., A.E.-O.), Monash University, Melbourne, Victoria, Australia.; Epigenetics in Human Health and Disease (H. Kaipananickal, J.O., A.E.-O.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health (K.L.W., D.G.D., H. Kiriazis, H. Kaipananickal, J.O., A.E.-O.), The University of Melbourne, Parkville, Victoria, Australia., Anderson D; Monash Institute of Pharmaceutical Sciences (D.A., D.J.C.), Monash University, Melbourne, Victoria, Australia., Creek DJ; Monash Institute of Pharmaceutical Sciences (D.A., D.J.C.), Monash University, Melbourne, Victoria, Australia., Mackay CR; School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China (C.R.M.)., El-Osta A; Epigenetics in Human Health and Disease, Department of Diabetes, Central Clinical School, Alfred Centre (H. Kaipananickal, J.O., A.E.-O.), Monash University, Melbourne, Victoria, Australia.; Epigenetics in Human Health and Disease (H. Kaipananickal, J.O., A.E.-O.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health (K.L.W., D.G.D., H. Kiriazis, H. Kaipananickal, J.O., A.E.-O.), The University of Melbourne, Parkville, Victoria, Australia., Pinto AR; Cardiac Cellular Systems (M.S.I.D., C.K., C.D.C., G.E.F., A.R.P.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Centre for Cardiovascular Biology and Disease Research (C.K., C.D.C., A.R.P.), La Trobe University, Melbourne, Victoria, Australia., Kaye DM; School of Translational Medicine, Faculty of Medicine Nursing and Health Sciences (D.G.D., D.M.K.), Monash University, Melbourne, Victoria, Australia.; Heart Failure Research Group (H.A.J., W.A.S., D.M.K., F.Z.M.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia (D.G.D., D.M.K.)., Marques FZ; Hypertension Research Laboratory, School of Biological Sciences (H.A.J., E.D., M.N., M.R.P., F.Z.M.), Monash University, Melbourne, Victoria, Australia.; Victorian Heart Hospital (F.Z.M.), Monash University, Melbourne, Victoria, Australia.; Heart Failure Research Group (H.A.J., W.A.S., D.M.K., F.Z.M.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

Publikováno v: Circulation research [Circ Res] 2024 Aug 02; Vol. 135 (4), pp. 537-539. Date of Electronic Publication: 2024 Jul 17.

Myocardial glycophagy flux dysregulation and glycogen accumulation characterize diabetic cardiomyopathy.

Autor: Mellor KM; Department of Physiology, University of Auckland, Auckland, New Zealand; Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Varma U; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Koutsifeli P; Department of Physiology, University of Auckland, Auckland, New Zealand., Daniels LJ; Department of Physiology, University of Auckland, Auckland, New Zealand; Radcliffe Department of Medicine, OCDEM, University of Oxford, United Kingdom., Benson VL; Department of Physiology, University of Auckland, Auckland, New Zealand., Annandale M; Department of Physiology, University of Auckland, Auckland, New Zealand., Li X; Department of Physiology, University of Auckland, Auckland, New Zealand., Nursalim Y; Department of Physiology, University of Auckland, Auckland, New Zealand., Janssens JV; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia; Department of Biomedical Sciences, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, USA., Weeks KL; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia., Powell KL; Department of Medicine, University of Melbourne & Department of Neuroscience, Central Clinical School Monash University, Melbourne, Victoria, Australia., O'Brien TJ; Department of Medicine, University of Melbourne & Department of Neuroscience, Central Clinical School Monash University, Melbourne, Victoria, Australia., Katare R; Department of Physiology, Heart Otago, University of Otago, Dunedin, New Zealand., Ritchie RH; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia., Bell JR; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia; Department of Microbiology, Anatomy, Physiology & Pharmacology, La Trobe University, Australia., Gottlieb RA; Department of Biomedical Sciences, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, USA., Delbridge LMD; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia. Electronic address: lmd@unimelb.edu.au.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2024 Apr; Vol. 189, pp. 83-89. Date of Electronic Publication: 2024 Mar 13.

A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology.

Autor: Weeks KL; Department of Anatomy and Physiology, University of Melbourne, Parkville, VIC, 3010, Australia.; Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, 3010, Australia.; Department of Diabetes, Central Clinical School, Monash University, Clayton, VIC, 3800, Australia., Kiriazis H; Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, 3010, Australia.; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia., Wadley GD; Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC, 3125, Australia., Masterman EI; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia., Sergienko NM; Department of Diabetes, Central Clinical School, Monash University, Clayton, VIC, 3800, Australia.; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia., Raaijmakers AJA; Department of Anatomy and Physiology, University of Melbourne, Parkville, VIC, 3010, Australia., Trewin AJ; Department of Anatomy and Physiology, University of Melbourne, Parkville, VIC, 3010, Australia., Harmawan CA; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia., Yildiz GS; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia., Liu Y; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia., Drew BG; Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, 3010, Australia.; Department of Diabetes, Central Clinical School, Monash University, Clayton, VIC, 3800, Australia.; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia., Gregorevic P; Department of Anatomy and Physiology, University of Melbourne, Parkville, VIC, 3010, Australia.; Centre for Muscle Research, University of Melbourne, Parkville, VIC, 3010, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia.; Department of Neurology, University of Washington School of Medicine, Seattle, WA, 98195, USA., Delbridge LMD; Department of Anatomy and Physiology, University of Melbourne, Parkville, VIC, 3010, Australia., McMullen JR; Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, 3010, Australia.; Department of Diabetes, Central Clinical School, Monash University, Clayton, VIC, 3800, Australia.; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia.; Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, VIC, 3086, Australia., Bernardo BC; Department of Diabetes, Central Clinical School, Monash University, Clayton, VIC, 3800, Australia. bianca.bernardo@baker.edu.au.; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia. bianca.bernardo@baker.edu.au.; Department of Paediatrics, University of Melbourne, Parkville, VIC, 3010, Australia. bianca.bernardo@baker.edu.au.

Publikováno v: Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2024 Jan; Vol. 102 (1), pp. 95-111. Date of Electronic Publication: 2023 Nov 21.