Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Wee-Chuang Low"'
Publikováno v:
Journal of Biological Chemistry. 288:29518-29529
The primary cilium is required for Hedgehog signaling. So far, all known ciliogenic proteins regulate Hedgehog signaling through their role in ciliogenesis. Here we show that the mouse DZIP1 regulates Hedgehog signaling through two mechanisms. First,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062488a7e0be8da06686f49ce9c10997
https://doi.org/10.1074/jbc.m113.492066
https://doi.org/10.1074/jbc.m113.492066
Autor:
Masafumi Ihara, Arthur E. Oakley, Raj N. Kalaria, Yumi Yamamoto, Tim Moss, Roger Wee Chuang Low, Tuomo Polvikoski, Carina Tham, Janet Y. Slade
Publikováno v:
Stroke. 40:2004-2011
Background and Purpose— White matter (WM) hyperintensities on MRI or leukoaraiosis is characteristic of stroke syndromes. Increased MRI signals in the anterior temporal pole are suggested to be diagnostic for cerebral autosomal-dominant arteriopath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5346d30c203b382db140677e734d84b0
https://doi.org/10.1161/strokeaha.108.528299
https://doi.org/10.1161/strokeaha.108.528299
Publikováno v:
Developmental Biology. 321:188-196
The Hedgehog (Hh) signal is transmitted by two receptor molecules, Patched (Ptc) and Smoothened (Smo). Ptc suppresses Smo activity, while Hh binds Ptc and alleviates the suppression, which results in activation of Hh targets. Smo is a seven-transmemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c82b4daf4d9c10699a25b116ea0208f
https://doi.org/10.1016/j.ydbio.2008.06.014
https://doi.org/10.1016/j.ydbio.2008.06.014
Autor:
Harpal Rao, Alvera Vorster, Stuart Rutherfoord, Jeannine M. Heckmann, Cora de Villiers, Christopher Morris, Wee-Chuang Low, Raj N. Kalaria, Raj Ramesar
Publikováno v:
Brain. 127:133-142
Genetically determined Alzheimer's disease (AD) is virtually unknown in Africa. We report clinicopathological findings and a presenilin 1 (PS1) mutation associated with early-onset AD in a large Xhosa family from Southern Africa. Twelve individuals s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c58f63617b2e63c4caf79c8157fef0b
https://doi.org/10.1093/brain/awh009
https://doi.org/10.1093/brain/awh009
Autor:
Lucinda J. L. Craggs, Arthur E. Oakley, Raj N. Kalaria, Yumi Yamamoto, Trevor A. Booth, Johannes Attems, Roger Wee Chuang Low, Atsushi Watanabe
Publikováno v:
Journal of neuropathology and experimental neurology. 72(5)
Cerebral autosomal dominant arteriopathy with subcortical in-farcts and leukoencephalopathy (CADASIL), the most common form of familial brain arteriopathy, is associated with deposition of granular osmiophilic material (GOM). We used immunohistochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3435b7e5d4696db9372ebe8718c7b3a
https://pubmed.ncbi.nlm.nih.gov/23877250
https://pubmed.ncbi.nlm.nih.gov/23877250
Autor:
Wee-Chuang Low, D. St Clair, T.H. Moss, Anne Börjesson-Hanson, T. Mizuno, Oluf Andersen, Jan Wahlström, Wei Wei Zhang, Hannu Kalimo, Kati Mykkänen, Raj N. Kalaria, Christopher Morris, Matti Viitanen, Maija Junna, D.L. Stevens
Publikováno v:
Brain : a journal of neurology. 130(Pt 2)
Several hereditary small vessel diseases (SVDs) of the brain have been reported in recent years. In 1977, Sourander and Walinder described hereditary multi-infarct dementia (MID) in a Swedish family. In the same year, Stevens and colleagues reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0a61226229b747ad68eddaf0279a69
https://pubmed.ncbi.nlm.nih.gov/17235124
https://pubmed.ncbi.nlm.nih.gov/17235124
Publikováno v:
Neuroreport. 17(10)
CADASIL is associated with mutations in the Notch3 gene but the causal mechanisms of the disorder remain unclear. We studied effects of widely established mutations on Notch3 receptor processing and ligand-mediated activation in stable lines of HEK29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f453e0114b66dfc4c9f381aff529e7
https://pubmed.ncbi.nlm.nih.gov/16791082
https://pubmed.ncbi.nlm.nih.gov/16791082
Publikováno v:
Journal of Biological Chemistry. 10/11/2013, Vol. 288 Issue 41, p29518-29529. 12p.
Autor:
Jeannine M. Heckmann, Wee-Chuang Low, Cora de Villiers, Stuart Rutherfoord, Alvera Vorster, Harpal Rao, Christopher M. Morris, Raj S. Ramesar, Raj N. Kalaria
Publikováno v:
Brain: A Journal of Neurology; 1/1/2004, Vol. 127 Issue 1, p133-142, 10p