Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Wee Kiang Yeo"'
Publikováno v:
ChemMedChem. 7:977-982
Publikováno v:
ChemMedChem. 6:713-724
The ability of aurones to modulate the efflux activities of ABCG2 and ABCB1 was investigated by quantifying their effects on the accumulation of pheophorbide A (PhA) in ABCG2-overexpressing MDA-MB-231/R cells and calcein AM in ABCB1-overexpressing MD
Autor:
Sepp D. Kohlwein, Markus R. Wenk, Guanghou Shui, Thomas Dick, Wee Kiang Yeo, Klaus Natter, Srinivasa P. S. Rao, Kai Leng Low
Publikováno v:
Journal of Biological Chemistry. 285:21662-21670
Mycobacteria store triacylglycerols (TGs) in the form of intracellular lipid droplets (LDs) during hypoxia-induced nonreplicating persistence. These bacteria are phenotypically drug-resistant and therefore are believed to be the cause for prolonged t
Autor:
Bing Zhang, Xi Kai Wee, Tong Earn Tay, Mei-Lin Go, Wee Kiang Yeo, Kian Meng Lim, Vincent B. C. Tan
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:7562-7571
A series of functionalized isoindigos structurally related to meisoindigo (1-methylisoindigo), a therapeutic agent used for the treatment of a form of leukemia, were synthesized and evaluated for antiproliferative activities on a panel of human cance
Publikováno v:
The FASEB Journal. 20:1152-1161
Kainate is a glutamate analog that has been widely used in pharmacological studies of neuronal injury related to ischemic conditions and epilepsy. While altered lipid metabolism has been implicated in kainate action, no study has yet investigated the
Publikováno v:
American Journal of PharmacoGenomics. 5:281-292
The ultimate goal of cancer proteomics is to adapt proteomic technologies for routine use in clinical laboratories for the purpose of diagnostic and prognostic classification of disease states, as well as in evaluating drug toxicity and efficacy. Ana
Internet resources for proteins associated with drug therapeutic effects, adverse reactions and ADME
Autor:
Xin Chen, Li Zhi Sun, Lixia Yao, Cong Z Cai, Ji F Wang, Lianyi Han, Zhi W Cao, Zhi L Ji, Chan J Zheng, Yu Zong Chen, Wee Kiang Yeo
Publikováno v:
Drug Discovery Today. 8:526-529
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 71
2-Phenylaminophenylacetic acid is a widely-exploited chemical scaffold whereby notable NSAIDs such as diclofenac and lumiracoxib were derived. Yet, their clinical usage has been associated with toxicities in the liver. While some studies have attribu
Publikováno v:
Journal of computer-aided molecular design. 26(10)
Compounds known to be potent against a specific protein target may potentially contain a signature profile of common substructures that is highly correlated to their potency. These substructure profiles may be useful in enriching compound libraries o
Autor:
Lixia Yao, Yu Zong Chen, Zhiliang Ji, Wee Kiang Yeo, Y. T. Tay, A. Muhammad, Lianyi Han, P. C. Chung, H. S. Puy, Xiang Chen, C. J. Zhen
Publikováno v:
Nucleic acids research. 31(1)
Understanding of cellular processes and underlying molecular events requires knowledge about different aspects of molecular interactions, networks of molecules and pathways in addition to the sequence, structure and function of individual molecules i