Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart

Autor: Yanwen Wang, Wee Khang Lin, William Crawford, Haibo Ni, Emma L. Bolton, Huma Khan, Julia Shanks, Gil Bub, Xin Wang, David J. Paterson, Henggui Zhang, Antony Galione, Steven N. Ebert, Derek A. Terrar, Ming Lei

Publikováno v: Scientific Reports
Wang, Y, Lin, W K, Crawford, W, Ni, H, Bolton, E L, Khan, H, Shanks, J, Bub, G, Wang, X, Paterson, D J, Zhang, H, Galione, A, Ebert, S N, Terrar, D A & Lei, M 2017, ' Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt + Cells in Murine Heart ', Scientific Reports, vol. 7, 40687 . https://doi.org/10.1038/srep40687

In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::76c1c5548be5c539610d86288d2e1012
http://europepmc.org/articles/PMC5234027

Inhibition of angiotensin II-induced cardiac hypertrophy and associated ventricular arrhythmias by a p21 activated kinase 1 bioactive peptide

Autor: Wei Liu, Yanmin Zhang, Wee Khang Lin, R. John Solaro, Yanwen Wang, Yunbo Ke, Derek A. Terrar, Ming Lei, Kai Huang, Xin Wang, Rui Wang

Publikováno v: Wang, R, Wang, X, Lin, W K, Zhang, Y, Liu, W, Huang, K, Terrar, D A, Solaro, R J, Ke4, Y & Lei, M 2014, ' Inhibition of angiotensin II-induced cardiac hypertrophy and associated ventricular arrhythmias by a p21 activated kinase 1 bioactive peptide ', P L o S One, vol. 9, no. 7, e101974 . https://doi.org/10.1371/journal.pone.0101974
PLoS ONE, Vol 9, Iss 7, p e101974 (2014)
PLoS ONE

Cardiac hypertrophy increases the risk of morbidity and mortality of cardiovascular disease and thus inhibiting such hypertrophy is beneficial. In the present study, we explored the effect of a bioactive peptide (PAP) on angiotensin II (Ang II)-induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344eb9b4564fa48bf58a2f97c15883a1
https://www.research.manchester.ac.uk/portal/en/publications/inhibition-of-angiotensin-iiinduced-cardiac-hypertrophy-and-associated-ventricular-arrhythmias-by-a-p21-activated-kinase-1-bioactive-peptide(8a40fb69-1cd1-46dc-a281-cd8852dfe1bb).html

NAADP AS A NOVEL DOWNSTREAM MEDIATOR OF CARDIAC BETA-ADRENERGIC PATHWAY

Autor: Derek A. Terrar, Emma L. Bolton, Wee Khang Lin, Antony Galione, Rebecca A. Capel

Publikováno v: Heart. 100:A21.3-A22

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent endogenous Ca2+ mobilizing second messenger that is known to release Ca2+ from the acidic endolysosomal vesicles. Our previous work showed that intracellular application of NAADP led t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecd56d19c3adc2c70a33a626cd4987d7
https://doi.org/10.1136/heartjnl-2014-306916.65

BDNF-Dependent Plasticity Induced by Peripheral Inflammation in the Primary Sensory and the Cingulate Cortex Triggers Cold Allodynia and Reveals a Major Role for Endogenous BDNF As a Tuner of the Affective Aspect of Pain.

Autor: Thibault, Karine, Wee Khang Lin, Rancillac, Armelle, Fan, Marie, Snollaerts, Thibaut, Sordoillet, Vallier, Hamon, Michel, Smith, George M., Lenkei, Zsolt, Pezet, Sophie

Publikováno v: Journal of Neuroscience; 10/29/2014, Vol. 34 Issue 44, p14739-14751, 13p

Contributions of I(F) and Sarcoplasmic Reticulum Ca2+ in the Control of Spontaneous Cardiac Beating Rate in Mouse and Guinea-Pig

Autor: Wee Khang Lin, Qiong Xiao, Derek A. Terrar, Islom B. Nazarov

Publikováno v: Biophysical Journal. (2):531a

Spontaneous beating rate was studied in mouse isolated atrial preparations and in guinea-pig single myocytes isolated from the sinus node (SAN) region of the heart. In atrial preparations, the I(f) blockers ZD7288 (1 μM) and ivabradine (3 μM) both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b573dc31e0891df26456f50de12dce47