Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Wedge, DC"'
Autor:
Sousos, N, Ní Leathlobhair, M, Simoglou Karali, C, Louka, E, Bienz, N, Royston, D, Clark, S-A, Hamblin, A, Howard, K, Mathews, V, George, B, Roy, A, Psaila, B, Wedge, DC, Mead, AJ
Publikováno v:
Nature Medicine. 28:1207-1211
The latency between acquisition of an initiating somatic driver mutation by a single-cell and clinical presentation with cancer is largely unknown. We describe a remarkable case of monozygotic twins presenting with CALR mutation-positive myeloprolife
Autor:
Katz-Summercorn, AC, Jammula, S, Frangou, A, Peneva, I, O'Donovan, M, Tripathi, M, Malhotra, S, Di Pietro, M, Abbas, S, Devonshire, G, Januszewicz, W, Blasko, A, Nowicki-Osuch, K, MacRae, S, Northrop, A, Redmond, AM, Wedge, DC, Fitzgerald, RC
Publikováno v:
Nature Communications. 13
Barrett’s esophagus is a pre-malignant lesion that can progress to esophageal adenocarcinoma. We perform a multi-omic analysis of pre-cancer samples from 146 patients with a range of outcomes, comprising 642 person years of follow-up. Whole genome
Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer samples. From joint analysis of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5324dc0a7418e6cbc8c1093a73f32c
Autor:
Gundem, G, Van Loo, P, Kremeyer, B, Alexandrov, LB, Tubio, JMC, Papaemmanuil, E, Brewer, DS, Kallio, HML, Högnäs, G, Annala, M, Kivinummi, K, Goody, V, Latimer, C, O'Meara, S, Dawson, KJ, Isaacs, W, Emmert-Buck, MR, Nykter, M, Foster, C, Kote-Jarai, Z, Easton, D, Whitaker, HC, ICGC Prostate Group, Neal, DE, Cooper, CS, Eeles, RA, Visakorpi, T, Campbell, PJ, McDermott, U, Wedge, DC, Bova, GS
Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::aa744f9eb456ea78a23dc695031d5294
https://www.repository.cam.ac.uk/handle/1810/267182
https://www.repository.cam.ac.uk/handle/1810/267182
Autor:
Woll, PS, Kjällquist, U, Chowdhury, O, Doolittle, H, Wedge, DC, Thongjuea, S, Erlandsson, R, Ngara, M, Anderson, K, Deng, Q, Mead, AJ, Stenson, L, Giustacchini, A, Duarte, S, Giannoulatou, E, Taylor, S, Karimi, M, Scharenberg, C, Mortera-Blanco, T, Macaulay, IC, Clark, S-A, Dybedal, I, Josefsen, D, Fenaux, P, Hokland, P, Holm, MS, Cazzola, M, Malcovati, L, Tauro, S, Bowen, D, Boultwood, J, Pellagatti, A, Pimanda, JE, Unnikrishnan, A, Vyas, P, Göhring, G, Schlegelberger, B, Tobiasson, M, Kvalheim, G, Constantinescu, SN, Nerlov, C, Nilsson, L, Campbell, PJ, Sandberg, R, Papaemmanuil, E, Hellström-Lindberg, E, Linnarsson, S, Jacobsen, SW
Publikováno v:
Woll, P S, Kjällquist, U, Chowdhury, O, Doolittle, H, Wedge, D C, Thongjuea, S, Erlandsson, R, Ngara, M, Anderson, K, Deng, Q, Mead, A J, Stenson, L, Giustacchini, A, Duarte, S, Giannoulatou, E, Taylor, S, Karimi, M, Scharenberg, C, Mortera-Blanco, T, Macaulay, I C, Clark, S A, Dybedal, I, Josefsen, D, Fenaux, P, Hokland, P, Holm, M S, Cazzola, M, Malcovati, L, Tauro, S, Bowen, D, Boultwood, J, Pellagatti, A, Pimanda, J E, Unnikrishnan, A, Vyas, P, Göhring, G, Schlegelberger, B, Tobiasson, M, Kvalheim, G, Constantinescu, S N, Nerlov, C, Nilsson, L, Campbell, P J, Sandberg, R, Papaemmanuil, E, Hellström-Lindberg, E, Linnarsson, S & Jacobsen, S W 2014, ' Erratum to Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo [Cancer Cell, 25 (2014) 794-808] ', Cancer Cell, vol. 25, no. 6 . https://doi.org/10.1016/j.ccr.2014.05.027
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::396726e4222f40b51c19ecb438508d3e
https://pure.au.dk/portal/da/publications/erratum-to-myelodysplastic-syndromes-are-propagated-by-rare-and-distinct-human-cancer-stem-cells-in-vivo-cancer-cell-25-2014-794808(16bcc7e6-bbf9-4450-8177-5f97661a5eed).html
https://pure.au.dk/portal/da/publications/erratum-to-myelodysplastic-syndromes-are-propagated-by-rare-and-distinct-human-cancer-stem-cells-in-vivo-cancer-cell-25-2014-794808(16bcc7e6-bbf9-4450-8177-5f97661a5eed).html
Autor:
Van 'T Veer, Laura, Alexandrov, LB, Nik-Zainal, S, Wedge, DC, Aparicio, SAJR, Behjati, S, Biankin, AV, Bignell, GR, Bolli, N, Borg, A, Børresen-Dale, A-L
Publikováno v:
Van 'T Veer, Laura; Alexandrov, LB; Nik-Zainal, S; Wedge, DC; Aparicio, SAJR; Behjati, S; et al.(2013). Signatures of mutational processes in human cancer.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/19r1d89d
All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a cancer genome bears the signatures of the mutational processes that have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::901704bd47f17a65513a2b73adc32ffc
http://www.escholarship.org/uc/item/19r1d89d
http://www.escholarship.org/uc/item/19r1d89d
Autor:
Cooper, CS, Eeles, R, Wedge, DC, Van Loo, P, Gundem, G, Alexandrov, LB, Kremeyer, B, Butler, A, Lynch, AG, Camacho, N, Massie, CE, Kay, J, Luxton, HJ, Edwards, S, Kote-Jarai, Z, Dennis, N, Merson, S, Leongamornlert, D, Zamora, J, Corbishley, C, Thomas, S, Nik-Zainal, S, Ramakrishna, M, O'Meara, S, Matthews, L, Clark, J, Hurst, R, Mithen, R, Bristow, RG, Boutros, PC, Fraser, M, Cooke, S, Raine, K, Jones, D, Menzies, A, Stebbings, L, Hinton, J, Teague, J, McLaren, S, Mudie, L, Hardy, C, Anderson, E, Joseph, O, Goody, V, Robinson, B, Maddison, M, Gamble, S, Greenman, C, Berney, D, Hazell, S, Livni, N, ICGC Prostate Group, Fisher, C, Ogden, C, Kumar, P, Thompson, A, Woodhouse, C, Nicol, D, Mayer, E, Dudderidge, T, Shah, NC, Gnanapragasam, V, Voet, T, Campbell, P, Futreal, A, Easton, D, Warren, AY, Foster, CS, Stratton, MR, Whitaker, HC, McDermott, U, Brewer, DS, Neal, DE
Publikováno v:
Nature Genetics. 47:689-689
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Autor:
Hong, MKH, Macintyre, G, Wedge, DC, Van Loo, P, Patel, K, Lunke, S, Alexandrov, LB, Sloggett, C, Cmero, M, Marass, F, Tsui, D, Mangiola, S, Lonie, A, Naeem, H, Sapre, N, Phal, PM, Kurganovs, N, Chin, X, Kerger, M, Warren, AY, Neal, D, Gnanapragasam, V, Rosenfeld, N, Pedersen, JS, Ryan, A, Haviv, I, Costello, AJ, Corcoran, NM, Hovens, CM
Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and progression to lethality is poorly understood. Here we reveal the precise direction of met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75a72154a1831c4fabd17385848c6dc5
Autor:
Behjati, S, Gundem, G, Wedge, DC, Roberts, ND, Tarpey, PS, Cooke, SL, Van Loo, P, Alexandrov, LB, Ramakrishna, M, Davies, H, Nik-Zainal, S, Hardy, C, Latimer, C, Raine, KM, Stebbings, L, Menzies, A, Jones, D, Shepherd, R, Butler, AP, Teague, JW, Jorgensen, M, Khatri, B, Pillay, N, Shlien, A, Futreal, PA, Badie, C, ICGC Prostate Group, McDermott, U, Bova, GS, Richardson, AL, Flanagan, AM, Stratton, MR, Campbell, PJ
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched for signatures of ionizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b76bf55c6f954e0b4de0c5c67db3d0ba