Differences in nanoscale organization of DNase I hypersensitive and insensitive chromatin in single human cells

Autor: David Hoerl, John A. Stamatoyannopoulos, Wedemann G, Katharina Brandstetter, Eric Haugen, Eric Rynes, Zuelske T, Ragoczy T, Hartmann Harz, Heinrich Leonhardt

Methodological advances in conformation capture techniques have fundamentally changed our understanding of chromatin architecture. However, the nanoscale organization of chromatin and its cell-to-cell variance are less studied. By using a combination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48b7c8dc8b3e570ade02565e8e77d844
https://doi.org/10.1101/2021.05.27.445943

Differences in nanoscale organization of regulatory active and inactive human chromatin.

Autor: Brandstetter K; Human Biology & BioImaging, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany., Zülske T; Competence Center Bioinformatics, Institute for Applied Computer Science, Hochschule Stralsund, Stralsund, Germany., Ragoczy T; Altius Institute for Biomedical Sciences, Seattle, Washington., Hörl D; Human Biology & BioImaging, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany., Guirao-Ortiz M; Human Biology & BioImaging, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany., Steinek C; Human Biology & BioImaging, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany., Barnes T; Biomedical Center (BMC), Molecular Biology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Martinsried, Germany., Stumberger G; Human Biology & BioImaging, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany., Schwach J; Human Biology & BioImaging, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany., Haugen E; Altius Institute for Biomedical Sciences, Seattle, Washington., Rynes E; Altius Institute for Biomedical Sciences, Seattle, Washington., Korber P; Biomedical Center (BMC), Molecular Biology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Martinsried, Germany., Stamatoyannopoulos JA; Altius Institute for Biomedical Sciences, Seattle, Washington; Department of Genome Sciences, University of Washington, Seattle, Washington; Department of Medicine, Division of Oncology, University of Washington, Seattle, Washington., Leonhardt H; Human Biology & BioImaging, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany., Wedemann G; Competence Center Bioinformatics, Institute for Applied Computer Science, Hochschule Stralsund, Stralsund, Germany. Electronic address: gero.wedemann@hochschule-stralsund.de., Harz H; Human Biology & BioImaging, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address: harz@biologie.uni-muenchen.de.

Publikováno v: Biophysical journal [Biophys J] 2022 Mar 15; Vol. 121 (6), pp. 977-990. Date of Electronic Publication: 2022 Feb 10.

Absence of convection in solid tumors caused by raised interstitial fluid pressure severely limits success of chemotherapy-a numerical study in cancers.

Autor: Hoffmann B; Competence Center Bioinformatics, Institute for Applied Computer Science, University of Applied Sciences Stralsund, Zur Schwedenschanze 15, 18435 Stralsund, Germany., Schumacher U; Institute for Anatomy and Experimental Morphology, University Cancer Center, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany., Wedemann G; Competence Center Bioinformatics, Institute for Applied Computer Science, University of Applied Sciences Stralsund, Zur Schwedenschanze 15, 18435 Stralsund, Germany.

Publikováno v: Mathematical biosciences and engineering : MBE [Math Biosci Eng] 2020 Sep 14; Vol. 17 (5), pp. 6128-6148.

TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning

Autor: Diermeier S, Kolovos P, Heizinger L, Schwartz U, Georgomanolis T, Zirkel A, Wedemann G, Grosveld F, Ta, Knoch, Rainer Merkl, Pr, Cook, Längst G, Papantonis A

Publikováno v: Europe PubMed Central

Background The rearrangement of nucleosomes along the DNA fiber profoundly affects gene expression, but little is known about how signalling reshapes the chromatin landscape, in three-dimensional space and over time, to allow establishment of new tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c116b2e60c23a859573b342dbd370cc8
https://epub.uni-regensburg.de/31287/

Exploring the potential of the convergence between extracellular vesicles and CAR technology as a novel immunotherapy approach.

Autor: Bar, Ofir¹ (AUTHOR), Porgador, Angel¹ (AUTHOR), Cooks, Tomer¹ (AUTHOR) cooks@bgu.ac.il

Publikováno v: Journal of Extracellular Biology. Sep2024, Vol. 3 Issue 9, p1-24. 24p.