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Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand.

Autor: Liu L; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Prime ME; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Lee MR; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Khetarpal V; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Brown CJ; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Johnson PD; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Miranda-Azpiazu P; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden., Chen X; Albany Molecular Research, Inc., 1001 Main St., Buffalo, New York 14203, United States., Clark-Frew D; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Coe S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Davis R; Albany Molecular Research, Inc., 1001 Main St., Buffalo, New York 14203, United States., Dickie A; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Ebneth A; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Esposito S; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30, 600, 00071 Pomezia (RM), Italy., Gadouleau E; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Gai X; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Galan S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Green S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Greenaway C; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Giles P; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Halldin C; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden., Hayes S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Herbst T; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Herrmann F; Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany., Heßmann M; Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany., Jia Z; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden., Kiselyov A; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Kotey A; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Krulle T; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Mangette JE; Albany Molecular Research, Inc., 1001 Main St., Buffalo, New York 14203, United States., Marston RW; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Menta S; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30, 600, 00071 Pomezia (RM), Italy., Mills MR; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Monteagudo E; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30, 600, 00071 Pomezia (RM), Italy., Nag S; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden., Nibbio M; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30, 600, 00071 Pomezia (RM), Italy., Orsatti L; IRBM, IRBM Science Park S.p.A., Via Pontina Km 30, 600, 00071 Pomezia (RM), Italy., Schaertl S; Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany., Scheich C; Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany., Sproston J; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Stepanov V; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden., Svedberg M; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden., Takano A; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden., Taylor M; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Thomas W; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Toth M; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden., Vaidya D; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Vanräs K; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden., Weddell D; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Wigginton I; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Wityak J; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Mrzljak L; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Munoz-Sanjuan I; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Bard JA; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Aug 13; Vol. 63 (15), pp. 8608-8633. Date of Electronic Publication: 2020 Jul 30.

Change as a learning situation.

Autor: Weddell D

Publikováno v: Psychotherapy and psychosomatics [Psychother Psychosom] 1965; Vol. 13 (1), pp. 200-5.