5-(Trifluoromethyl)-1,2,4-oxadiazole (TFMO)-based highly selective class IIa HDAC inhibitors exhibit synergistic anticancer activity in combination with bortezomib.

Autor: Asfaha Y; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany., Bollmann LM; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany., Skerhut AJ; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany., Fischer F; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany., Horstick N; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany., Roth D; Department of Surgery (A), Medical Faculty, University Hospital of the Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany., Wecker M; Department of Surgery (A), Medical Faculty, University Hospital of the Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany., Mammen C; Institute of Biochemistry I, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany., Smits SHJ; Institute of Biochemistry I, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany; Center for Structural Studies, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany., Fluegen G; Department of Surgery (A), Medical Faculty, University Hospital of the Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany., Kassack MU; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany., Kurz T; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany. Electronic address: thomas.kurz@hhu.de.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Jan 05; Vol. 263, pp. 115907. Date of Electronic Publication: 2023 Nov 10.

Synergistic Interaction of the Class IIa HDAC Inhibitor CHDI0039 with Bortezomib in Head and Neck Cancer Cells.

Autor: Schrenk C; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany., Bollmann LM; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany., Haist C; Department of Otorhinolaryngology, Head & Neck Surgery, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany., Bister A; Department of Otorhinolaryngology, Head & Neck Surgery, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany., Wiek C; Department of Otorhinolaryngology, Head & Neck Surgery, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany., Wecker M; Department of General, Visceral and Pediatric Surgery, Medical Faculty, University Hospital of the Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany., Roth D; Department of General, Visceral and Pediatric Surgery, Medical Faculty, University Hospital of the Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany., Petzsch P; Biological and Medical Research Centre (BMFZ), Genomics & Transcriptomics Laboratory, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany., Köhrer K; Biological and Medical Research Centre (BMFZ), Genomics & Transcriptomics Laboratory, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany., Hamacher A; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany., Hanenberg H; Department of Otorhinolaryngology, Head & Neck Surgery, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.; Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany., Fluegen G; Department of General, Visceral and Pediatric Surgery, Medical Faculty, University Hospital of the Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany., Kassack MU; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 14; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 14.

NETZ:KRAFT. Netzwiederaufbau unter Berücksichtigung zukünftiger Kraftwerksstrukturen. Öffentlicher Abschlussbericht

Autor: Heckmann, W., Becker, H., Hachmann, C., Spanel, U., Bernhart, A., Müller-Mienack, M., Shan, W., Welck, F., Wecker, M., Nuschke, M., Hau, D., Wunderlich, M., Akbulut, A., Pabon, L., Liebehentze, S., Görig, B., Lafferte, D., Klingmann, A., Valov, M., Fetzer, D., Fischbach, K., Paschedag, T., Lammert, G., Hof, M., Bülo, T., Hardt, C., Mahr, F., Jaworski, M., Schäfer, N., Nölle, C., Lohmeier, D., Rittger, C., Brandl, R.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2df2fd6cb179ec7b1d5fb53f5bc33b2

Why Is the Turnover Intention in Large Institutions Higher? Perceived Organizational Support, Organizational Cultural Identity, and Turnover Intention of Chinese Social Workers.

Autor: Huang, Dan¹, Luo, Yingting², Sun, Zhongwei³ sunzhwei@m.scnu.edu.cn

Publikováno v: Social Work Research. Dec2024, Vol. 48 Issue 4, p240-252. 13p.

Design of multivalent-epitope vaccine models directed toward the world's population against HIV-Gag polyprotein: Reverse vaccinology and immunoinformatics.

Autor: Hashempour, Ava¹ (AUTHOR), Khodadad, Nastaran¹ (AUTHOR), Bemani, Peyman^1,2 (AUTHOR) sbemani@chmail.ir, Ghasemi, Younes³ (AUTHOR), Akbarinia, Shokufeh¹ (AUTHOR), Bordbari, Reza¹ (AUTHOR), Tabatabaei, Amir Hossein¹ (AUTHOR), Falahi, Shahab^1,4 (AUTHOR) falahish@chmail.ir

Publikováno v: PLoS ONE. 9/27/2024, Vol. 19 Issue 9, p1-37. 37p.