Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection

Autor: Webster, SJ, Brode, S, Ellis, L, Fitzmaurice, TJ, Elder, MJ, Gekara, NO, Tourlomousis, P, Bryant, C, Clare, S, Chee, R, Gaston, HJS, Goodall, JC

Publikováno v: PLoS Pathogens, Vol 13, Iss 6, p e1006383 (2017)

The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between infectious and noninfectious insult to prevent inappropriate inflammation. Using the impor

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Rh(I)-Catalyzed Regio- and Enantioselective Ring Opening of Vinyl Cyclopropanes.

Autor: Webster SJ; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Balázs LB; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Goetzke FW; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Stojalnikova V; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Liu K; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Christensen KE; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Mackenzie HW; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Fletcher SP; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2024 Sep 04; Vol. 146 (35), pp. 24708-24715. Date of Electronic Publication: 2024 Aug 20.

Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.

Autor: Liu L; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Malagu K; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Haughan AF; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Khetarpal V; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Stott AJ; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Esmieu W; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Vater HD; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Webster SJ; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Van de Poël AJ; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Clissold C; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Cosgrove B; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Sutton B; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Spencer JA; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Breccia P; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Gancia E; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Bonomo S; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Ladduwahetty T; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Lazari O; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Patel H; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Atton HC; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Clifton S; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Mota DM; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Magnani D; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., O'Neill A; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Stebbeds M; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Macabuag N; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Todd D; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Herva ME; 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CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Lee MR; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Herbst T; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Monteagudo E; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Macdonald D; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Plotnikov NV; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Chambers M; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., McAllister G; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Muňoz-Sanjuan I; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Sep 28; Vol. 66 (18), pp. 13205-13246. Date of Electronic Publication: 2023 Sep 15.

Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections.

Autor: Digby Z; University of Cambridge, Department of Veterinary Medicine, Cambridge CB30ES, UK., Tourlomousis P; University of Cambridge, Department of Veterinary Medicine, Cambridge CB30ES, UK., Rooney J; University of Cambridge, Department of Veterinary Medicine, Cambridge CB30ES, UK., Boyle JP; University of Cambridge, Department of Veterinary Medicine, Cambridge CB30ES, UK., Bibo-Verdugo B; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines, La Jolla, CA 92037, USA., Pickering RJ; University of Cambridge, School of Clinical Medicine, Box 111, Cambridge Biomedical Campus, Cambridge CB2 0SP, UK., Webster SJ; University of Cambridge, Department of Veterinary Medicine, Cambridge CB30ES, UK., Monie TP; University of Cambridge, Department of Veterinary Medicine, Cambridge CB30ES, UK., Hopkins LJ; University of Cambridge, Department of Veterinary Medicine, Cambridge CB30ES, UK; University of Cambridge, School of Clinical Medicine, Box 111, Cambridge Biomedical Campus, Cambridge CB2 0SP, UK., Kayagaki N; Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA., Salvesen GS; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines, La Jolla, CA 92037, USA., Warming S; Department of Molecular Biology, Genentech, South San Francisco, CA 94080, USA., Weinert L; University of Cambridge, Department of Veterinary Medicine, Cambridge CB30ES, UK., Bryant CE; University of Cambridge, Department of Veterinary Medicine, Cambridge CB30ES, UK; University of Cambridge, School of Clinical Medicine, Box 111, Cambridge Biomedical Campus, Cambridge CB2 0SP, UK. Electronic address: ceb27@cam.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2021 Aug 24; Vol. 36 (8), pp. 109614.