Zobrazeno 1 - 10
of 368
pro vyhledávání: '"Webster K. Cavenee"'
Autor:
Mio Harachi, Kenta Masui, Erika Shimizu, Kumiko Murakami, Hiromi Onizuka, Yoshihiro Muragaki, Takakazu Kawamata, Hisako Nakayama, Mariko Miyata, Takashi Komori, Webster K. Cavenee, Paul S. Mischel, Atsushi Kurata, Noriyuki Shibata
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global “hypomethylator phenotype”, are associated with cancer. Here we show that an underlying mechanism for this phenotype in the
Externí odkaz:
https://doaj.org/article/59ba976a12834ee782df85c5cc6333ba
Autor:
Jinkal Modi, Abhishek Roy, Anjan K. Pradhan, Amit Kumar, Sarmistha Talukdar, Praveen Bhoopathi, Santanu Maji, Padmanabhan Mannangatti, Daniel Sanchez De La Rosa, Jiong Li, Chunqing Guo, Mark A. Subler, Jolene J. Windle, Webster K. Cavenee, Devanand Sarkar, Xiang-Yang Wang, Swadesh K. Das, Luni Emdad, Paul B. Fisher
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 72 (2021)
Melanoma differentiation associated gene-7/interleukin-24 (MDA-7/IL-24), a secreted protein of the IL-10 family, was first identified more than two decades ago as a novel gene differentially expressed in terminally differentiating human metastatic me
Externí odkaz:
https://doaj.org/article/59a86fd5b0994ae790bf0d93942476d5
Autor:
Jennifer P. Newman, Grace Y. Wang, Kazuhiko Arima, Shou P. Guan, Michael R. Waters, Webster K. Cavenee, Edward Pan, Edita Aliwarga, Siao T. Chong, Catherine Y. L. Kok, Berwini B. Endaya, Amyn A. Habib, Tomohisa Horibe, Wai H. Ng, Ivy A. W. Ho, Kam M. Hui, Tomasz Kordula, Paula Y. P. Lam
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Interleukin-13 receptor alpha 2 is highly expressed in glioblastoma multiforme but its role in this malignancy is unclear. Here the authors show that this receptor interacts with mutant EGFR, stimulating its kinase activity, thus inducing proliferati
Externí odkaz:
https://doaj.org/article/86a25a0c882247c39b38bbcac00ca539
Autor:
Jorge A. Benitez, Jianhui Ma, Matteo D’Antonio, Antonia Boyer, Maria Fernanda Camargo, Ciro Zanca, Stephen Kelly, Alireza Khodadadi-Jamayran, Nathan M. Jameson, Michael Andersen, Hrvoje Miletic, Shahram Saberi, Kelly A. Frazer, Webster K. Cavenee, Frank B. Furnari
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
PTEN mutations are frequent in glioblastoma and often are associated with therapeutic resistance. Here, the authors demonstrate that PTEN regulates gene expression at the chromatin level by interacting with the histone chaperone DAXX and H3.3, and th
Externí odkaz:
https://doaj.org/article/552fe99f5f044c3ab87a7c0942b022b9
Publikováno v:
npj Precision Oncology, Vol 1, Iss 1, Pp 1-5 (2017)
Abstract The cancer genome provides the blueprint for identifying oncogenic mutations driving tumor growth and these mutant proteins and pathways are the targets for precision cancer therapies. However, many oncogenes are capable of reprogramming the
Externí odkaz:
https://doaj.org/article/8741ff04de824f7585fff1793dbafe1b
Publikováno v:
Metabolites, Vol 11, Iss 4, p 216 (2021)
Metabolic reprogramming is an emerging hallmark of cancer and is driven by abnormalities of oncogenes and tumor suppressors. Accelerated metabolism causes cancer cell aggression through the dysregulation of rate-limiting metabolic enzymes as well as
Externí odkaz:
https://doaj.org/article/cb28c62a10c14f81afa227f81d1e15b1
Publikováno v:
Cancer Biology & Medicine, Vol 11, Iss 4, Pp 255-263 (2014)
Glioblastoma (GBM) is one of the most lethal human cancers. Genomic analyses define the molecular architecture of GBM and highlight a central function for mechanistic target of rapamycin (mTOR) signaling. mTOR kinase exists in two multi-protein compl
Externí odkaz:
https://doaj.org/article/28897c8046a8488bbaab5c8a1412c24c
Publikováno v:
Cancer Biology & Medicine, Vol 10, Iss 4, Pp 192-205 (2013)
Receptor tyrosine kinases (RTKs) such as the epidermal growth factor receptor (EGFR) regulate cellular homeostatic processes. EGFR activates downstream signaling cascades that promote tumor cell survival, proliferation and migration. Dysregulation of
Externí odkaz:
https://doaj.org/article/5e058b042a0d444e90f4c6b8eeb5396d
Autor:
Jorge A. Benitez, Jianhui Ma, Matteo D’Antonio, Antonia Boyer, Maria Fernanda Camargo, Ciro Zanca, Stephen Kelly, Alireza Khodadadi-Jamayran, Nathan M. Jameson, Michael Andersen, Hrvoje Miletic, Shahram Saberi, Kelly A. Frazer, Webster K. Cavenee, Frank B. Furnari
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 8:15223 doi: (2017); Published 12 May 2017; Updated 25 May 2018 The originally published version of this Article contained an error in Fig. 1. In panel d, the uppermost western blot was inadvertently inverted during typesetting
Externí odkaz:
https://doaj.org/article/ab99778515c1442e93d91528b2118026
Autor:
Masayuki Nitta, David Kozono, Richard Kennedy, Jayne Stommel, Kimberly Ng, Pascal O. Zinn, Deepa Kushwaha, Santosh Kesari, Frank Furnari, Katherine A. Hoadley, Lynda Chin, Ronald A. DePinho, Webster K. Cavenee, Alan D'Andrea, Clark C. Chen
Publikováno v:
PLoS ONE, Vol 6, Iss 4 (2011)
Externí odkaz:
https://doaj.org/article/01731528f1524eea8779560c91bc3b39