Zobrazeno 1 - 10
of 2 781
pro vyhledávání: '"Webster K"'
Autor:
Mio Harachi, Kenta Masui, Erika Shimizu, Kumiko Murakami, Hiromi Onizuka, Yoshihiro Muragaki, Takakazu Kawamata, Hisako Nakayama, Mariko Miyata, Takashi Komori, Webster K. Cavenee, Paul S. Mischel, Atsushi Kurata, Noriyuki Shibata
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global “hypomethylator phenotype”, are associated with cancer. Here we show that an underlying mechanism for this phenotype in the
Externí odkaz:
https://doaj.org/article/59ba976a12834ee782df85c5cc6333ba
Autor:
Richard C Lauer, Marc Barry, Tracey L Smith, Andrew Maltez Thomas, Jin Wu, Ruofei Du, Ji-Hyun Lee, Arpit Rao, Andrey S Dobroff, Marco A Arap, Diana N Nunes, Israel T Silva, Emmanuel Dias-Neto, Isan Chen, Dennis J McCance, Webster K Cavenee, Renata Pasqualini, Wadih Arap
Publikováno v:
eLife, Vol 12 (2023)
Background: We have previously shown that the long non-coding (lnc)RNA prostate cancer associated 3 (PCA3; formerly prostate cancer antigen 3) functions as a trans-dominant negative oncogene by targeting the previously unrecognized prostate cancer su
Externí odkaz:
https://doaj.org/article/54de7b4374ee4770b8c53468739cf642
Autor:
Jennifer P. Newman, Grace Y. Wang, Kazuhiko Arima, Shou P. Guan, Michael R. Waters, Webster K. Cavenee, Edward Pan, Edita Aliwarga, Siao T. Chong, Catherine Y. L. Kok, Berwini B. Endaya, Amyn A. Habib, Tomohisa Horibe, Wai H. Ng, Ivy A. W. Ho, Kam M. Hui, Tomasz Kordula, Paula Y. P. Lam
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Interleukin-13 receptor alpha 2 is highly expressed in glioblastoma multiforme but its role in this malignancy is unclear. Here the authors show that this receptor interacts with mutant EGFR, stimulating its kinase activity, thus inducing proliferati
Externí odkaz:
https://doaj.org/article/86a25a0c882247c39b38bbcac00ca539
Autor:
Andre A Teixeira, Serena Marchiò, Emmanuel Dias‐Neto, Diana N Nunes, Israel T da Silva, Bryce Chackerian, Marc Barry, Richard C Lauer, Ricardo J Giordano, Richard L Sidman, Cosette M Wheeler, Webster K Cavenee, Renata Pasqualini, Wadih Arap
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 10, Pp 1327-1330 (2017)
Graphical Abstract The hypothesis is discussed that prostate cancer marker lncRNA PCA3 was introduced into the human genome by an oncogenic virus, and that viral infection‐related mechanisms might underlie its overexpression and prostate cancer ini
Externí odkaz:
https://doaj.org/article/8d221eac6f144f378b13373e38c5f65b
Autor:
Jorge A. Benitez, Jianhui Ma, Matteo D’Antonio, Antonia Boyer, Maria Fernanda Camargo, Ciro Zanca, Stephen Kelly, Alireza Khodadadi-Jamayran, Nathan M. Jameson, Michael Andersen, Hrvoje Miletic, Shahram Saberi, Kelly A. Frazer, Webster K. Cavenee, Frank B. Furnari
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
PTEN mutations are frequent in glioblastoma and often are associated with therapeutic resistance. Here, the authors demonstrate that PTEN regulates gene expression at the chromatin level by interacting with the histone chaperone DAXX and H3.3, and th
Externí odkaz:
https://doaj.org/article/552fe99f5f044c3ab87a7c0942b022b9
Publikováno v:
npj Precision Oncology, Vol 1, Iss 1, Pp 1-5 (2017)
Abstract The cancer genome provides the blueprint for identifying oncogenic mutations driving tumor growth and these mutant proteins and pathways are the targets for precision cancer therapies. However, many oncogenes are capable of reprogramming the
Externí odkaz:
https://doaj.org/article/8741ff04de824f7585fff1793dbafe1b
Publikováno v:
Metabolites, Vol 11, Iss 4, p 216 (2021)
Metabolic reprogramming is an emerging hallmark of cancer and is driven by abnormalities of oncogenes and tumor suppressors. Accelerated metabolism causes cancer cell aggression through the dysregulation of rate-limiting metabolic enzymes as well as
Externí odkaz:
https://doaj.org/article/cb28c62a10c14f81afa227f81d1e15b1
Publikováno v:
Cancer Biology & Medicine, Vol 11, Iss 4, Pp 255-263 (2014)
Glioblastoma (GBM) is one of the most lethal human cancers. Genomic analyses define the molecular architecture of GBM and highlight a central function for mechanistic target of rapamycin (mTOR) signaling. mTOR kinase exists in two multi-protein compl
Externí odkaz:
https://doaj.org/article/28897c8046a8488bbaab5c8a1412c24c
Publikováno v:
Cancer Biology & Medicine, Vol 10, Iss 4, Pp 192-205 (2013)
Receptor tyrosine kinases (RTKs) such as the epidermal growth factor receptor (EGFR) regulate cellular homeostatic processes. EGFR activates downstream signaling cascades that promote tumor cell survival, proliferation and migration. Dysregulation of
Externí odkaz:
https://doaj.org/article/5e058b042a0d444e90f4c6b8eeb5396d