The impact of proinflammatory cytokines on the beta-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Autor: Ramos-Rodriguez, M, Raurell-Vila, H, Colli, ML, Alvelos, MI, Subirana-Granes, M, Juan-Mateu, J, Norris, R, Turatsinze, JV, Nakayasu, ES, Webb-Robertson, BJM, Inshaw, JRJ, Marchetti, P, Piemonti, L, Esteller, M, Todd, JA, Metz, TO, Eizirik, DL, Pasquali, L

Publikováno v: Nature Genetics
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic beta cells. Here we show that exposure to proinflammatory cytokines reveals a marked plasticity of the b

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https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1342

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Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images.

Autor: Oostrom M; AI & Data Analytics Division, Pacific Northwest National Laboratory, Richland, WA, United States of America., Muniak MA; Vollum Institute, Oregon Health & Science University, Portland, OR, United States of America., Eichler West RM; AI & Data Analytics Division, Pacific Northwest National Laboratory, Richland, WA, United States of America., Akers S; AI & Data Analytics Division, Pacific Northwest National Laboratory, Richland, WA, United States of America., Pande P; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States of America., Obiri M; AI & Data Analytics Division, Pacific Northwest National Laboratory, Richland, WA, United States of America., Wang W; Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States of America., Bowyer K; Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States of America., Wu Z; Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States of America., Bramer LM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States of America., Mao T; Vollum Institute, Oregon Health & Science University, Portland, OR, United States of America., Webb-Robertson BJM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States of America.

Publikováno v: PloS one [PLoS One] 2024 Mar 29; Vol. 19 (3), pp. e0293856. Date of Electronic Publication: 2024 Mar 29 (Print Publication: 2024).