Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Webb, ME"'
Publikováno v:
Organic & Biomolecular Chemistry. 20:7232-7235
The N-terminal substrate specificity of the SurE peptide cyclase was elucidated using a combination of on-resin biomemtic substrates and conventional SNAC thioesters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bb0a8678f58cffeb82d4186e7e7480
https://doi.org/10.1039/d2ob01061e
https://doi.org/10.1039/d2ob01061e
Site-specific protein modification is a widely-used biochemical tool. However, there are many challenges associated with the development of protein modification techniques, in particular, achieving site-specificity, reaction efficiency and versatilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::b7c40d00d8a5870512b59985d9d4cfc1
https://eprints.whiterose.ac.uk/186613/1/d0cs01148g.pdf
https://eprints.whiterose.ac.uk/186613/1/d0cs01148g.pdf
The terminal step in the biosynthesis of nonribosomal peptides is the hydrolytic release and, frequently, macrocyclization of an aminoacyl-S-thioester by an embedded thioesterase. The surugamide biosynthetic pathway is composed of two nonribosomal pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::736f5c7b97f9f1331b5fe9b254dc4159
Autor:
Ross, JF, Wildsmith, GC, Johnson, M, Hurdiss, DL, Hollingsworth, K, Thompson, RF, Mosayebi, M, Trinh, CH, Paci, E, Pearson, AR, Webb, ME, Turnbull, WB
Publikováno v:
Ross, J F, Wildsmith, G C, Johnson, M, Hurdiss, D L, Hollingsworth, K, Thompson, R F, Mosayebi, M, Trinh, C H, Paci, E, Pearson, A R, Webb, M E & Turnbull, W B 2019, ' Directed Assembly of Homopentameric Cholera Toxin B-Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages ', Journal of the American Chemical Society, vol. 141, no. 13, pp. 5211-5219 . https://doi.org/10.1021/jacs.8b11480
Journal of the American Chemical Society
Journal of the American Chemical Society
The self-assembly of proteins into higher order structures is ubiquitous in living systems. It is also an essential process for the bottom-up creation of novel molecular architectures and devices for synthetic biology. However, the complexity of prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::621f253f4b4ffeb75759e8b66a5871ce
https://eprints.whiterose.ac.uk/143515/14/jacs.8b11480.pdf
https://eprints.whiterose.ac.uk/143515/14/jacs.8b11480.pdf
Autor:
Monteiro, DCF, Patel, V, Bartlett, CP, Nozaki, S, Grant, TD, Gowdy, JA, Thompson, GS, Kalverda, AP, Snell, EH, Niki, H, Pearson, AR, Webb, ME
Publikováno v:
Chemistry & Biology. 22(4):492-503
SummaryCoenzyme A (CoA) is an ubiquitous and essential cofactor, synthesized from the precursor pantothenate. Vitamin biosynthetic pathways are normally tightly regulated, including the pathway from pantothenate to CoA. However, no regulation of pant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::26e3541ad50897c86f94914b0595aff8
The antimetabolite pentyl pantothenamide has broad spectrum antibiotic activity but exhibits enhanced activity against Escherichia coli. The PanDZ complex has been proposed to regulate the pantothenate biosynthetic pathway in E. coli by limiting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::2dfc20cb770602a4fc9cc585c1200583
Chemical formation of dehydroalanine has been widely used for the post-translational modification of protein and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::394bb186a8878f98c643484c3263a1bd
Publikováno v:
In Contraception October 2017 96(4):303-303
Publikováno v:
In Contraception October 2017 96(4):303-303
Publikováno v:
In Contraception October 2016 94(4):423-423