CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response

Autor: Wc, Gause, Sj, Chen, Rj, Greenwald, Mj, Halvorson, Lu P, Xd, Zhou, Sc, Morris, Kp, Lee, Ch, June, Fd, Finkelman, Joseph Urban, Abe R

Publikováno v: Europe PubMed Central

T cell differentiation to effector cell function is required for the development of a type 2 immune response. The T cell surface molecule, CD28, is widely considered to be the principal costimulatory molecule involved in T cell differentiation to eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1feb92171174fce4b835f732cf9d0772
https://pubmed.ncbi.nlm.nih.gov/9126966

CD40-mediated stimulation contributes to lymphocyte proliferation, antibody production, eosinophilia, and mastocytosis during an in vivo type 2 response, but is not required for T cell IL-4 production

Autor: Lu P, Joseph Urban, Xd, Zhou, Sj, Chen, Madden K, Moorman M, Nguyen H, Sc, Morris, Fd, Finkelman, Wc, Gause

Publikováno v: Europe PubMed Central

CD40/CD40 ligand interactions are required for the development of T cell-dependent Ab responses in vivo. The role of these cell surface molecules in contributing to T cell cytokine production and the development of effector populations other than B c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fc0f95999f9c148d66016196dc5fe319
http://europepmc.org/abstract/med/8617957

A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3

Autor: Svetić A, Kb, Madden, Xd, Zhou, Lu P, Im, Katona, Fd, Finkelman, Joseph Urban, Wc, Gause

Publikováno v: Europe PubMed Central

The immune response that is characteristic of parasitic helminth infections includes components associated with immediate-type hypersensitivity: elevated serum IgE, eosinophilia, and intestinal mast cell hyperplasia. In infection with the parasitic n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e0dd21214a0ce382aabf3c735c9cda0e
http://europepmc.org/abstract/med/8468481

Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration.

Autor: Lothstein KE; Center for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA., Chen F; Center for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA., Mishra P; Center for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA., Smyth DJ; Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK., Wu W; Center for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA., Lemenze A; Center for Immunity and Inflammation, Department of Pathology, Immunology, and Laboratory Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA., Kumamoto Y; Center for Immunity and Inflammation, Department of Pathology, Immunology, and Laboratory Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA., Maizels RM; Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK., Gause WC; Center for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA gausewc@njms.rutgers.edu.

Publikováno v: Life science alliance [Life Sci Alliance] 2024 Aug 23; Vol. 7 (11). Date of Electronic Publication: 2024 Aug 23 (Print Publication: 2024).

Protocol for immunofluorescence staining of murine helminth-infected intestinal and lung tissues.

Autor: El-Naccache DW; Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ 07101, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ 07101, USA., Chen F; Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ 07101, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ 07101, USA., Gause WC; Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ 07101, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ 07101, USA. Electronic address: gausewc@njms.rutgers.edu.

Publikováno v: STAR protocols [STAR Protoc] 2023 Apr 21; Vol. 4 (2), pp. 102208. Date of Electronic Publication: 2023 Apr 21.