Výsledky vyhledávání - "Wayomi R. Perera"

Update on treatment of small-cell lung cancer in the elderly

Publikováno v: Aging Health. 6:371-382

Small-cell lung cancer (SCLC) is the most aggressive form of lung cancer; it is characterized by a rapid tumor-doubling time and early metastasis. Although SCLC is extremely sensitive to chemotherapy, relapses are frequent and the 5-year survival is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb06e93db78fa4a5eb29b5b9af132a08
https://doi.org/10.2217/ahe.10.27

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Long-term Erythromycin Therapy Is Associated with Decreased Chronic Obstructive Pulmonary Disease Exacerbations

Autor: Tom Wilkinson, Terence A. R. Seemungal, Wayomi R. Perera, Jadwiga A. Wedzicha, John R. Hurst, Ray J. Sapsford

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 178:1139-1147

Frequent chronic obstructive pulmonary disease (COPD) exacerbations are a major cause of hospital admission and mortality and are associated with increased airway inflammation. Macrolides have airway antiinflammatory actions and may reduce the incide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2019b47d5e8c38db5f1456e124f087a3
https://doi.org/10.1164/rccm.200801-145oc

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Use of Plasma Biomarkers at Exacerbation of Chronic Obstructive Pulmonary Disease

Autor: John A. Bilello, Tom Wilkinson, Rupert S. Vessey, Gerry Hagan, John R. Hurst, Wayomi R. Perera, Jadwiga A. Wedzicha, Gavin C. Donaldson

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 174:867-874

This study explores the use of measuring plasma biomarkers at exacerbation of chronic obstructive pulmonary disease (COPD), providing insight into the underlying pathogenesis of these important events.The use of measuring C-reactive protein (CRP) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb3f4b4cd1e7ca5d70a32560cc1fdf0
https://doi.org/10.1164/rccm.200604-506oc

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Nasal symptoms, airway obstruction and disease severity in chronic obstructive pulmonary disease

Autor: John R. Hurst, Wayomi R. Perera, Philip Michael, Romana Kuchai, Tom M. A. Wilkinson, Jadwiga A. Wedzicha

Publikováno v: Clinical Physiology and Functional Imaging. 26:251-256

Summary Background: Chronic obstructive pulmonary disease (COPD) is characterized by inflammation of the lung in association with airflow obstruction. There is increasing evidence of upper airway involvement in COPD and we have reported that this nas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc2915da1723cd27ed1a16da355b164
https://doi.org/10.1111/j.1475-097x.2006.00683.x

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Effect of Interactions Between Lower Airway Bacterial and Rhinoviral Infection in Exacerbations of COPD

Autor: Gavin C. Donaldson, Jadwiga A. Wedzicha, Mark Wilks, Wayomi R. Perera, John R. Hurst, Tom Wilkinson

Publikováno v: Chest

Study objectives The inflammatory responses and associated clinical severity of COPD exacerbations are greatly variable, and the determinants of these factors are poorly understood. We examined the hypothesis that bacteria and viruses may modulate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f2527d961040932c52e3fb36d04a85
https://doi.org/10.1378/chest.129.2.317

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Epidemiological relationships between the common cold and exacerbation frequency in COPD

Autor: John R. Hurst, Jadwiga A. Wedzicha, Wayomi R. Perera, Tom Wilkinson, GC Donaldson

Publikováno v: European Respiratory Journal. 26:846-852

Higher exacerbation incidence rates in chronic obstructive pulmonary disease (COPD) are associated with more rapid decline in lung function and poorer quality of life, yet the mechanisms determining susceptibility to exacerbation remain ill-defined.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b258758c9573bbacc59e77115968af2f
https://doi.org/10.1183/09031936.05.00043405

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Relationships Among Bacteria, Upper Airway, Lower Airway, and Systemic Inflammation in COPD

Autor: Tom Wilkinson, Jadwiga A. Wedzicha, Wayomi R. Perera, Gavin C. Donaldson, John R. Hurst

Publikováno v: Chest. 127:1219-1226

Study objective: The upper and lower airways are continuous. While upper airway symptoms are common in COPD patients, with accumulating evidence to suggest increased nasal inflammation, the relationships among upper airway, lower airway, and systemic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b23f92ccbc2a686b37ca217a52768d8
https://doi.org/10.1016/s0012-3692(15)34470-6

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Exacerbation of chronic obstructive pulmonary disease: pan-airway and systemic inflammatory indices

Autor: TM Wilkinson, Wayomi R. Perera, Hurst, Gavin C. Donaldson, Jadwiga A. Wedzicha

Publikováno v: Proceedings of the American Thoracic Society. 3(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ae2a97808e3c08b3cb04c461f9432e
https://pubmed.ncbi.nlm.nih.gov/16921117

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Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary disease

Autor: Tom Wilkinson, Jadwiga A. Wedzicha, John R. Hurst, Gavin C. Donaldson, Wayomi R. Perera

Publikováno v: American journal of respiratory and critical care medicine. 173(1)

In addition to pulmonary involvement, stable chronic obstructive pulmonary disease (COPD) is associated with nasal and systemic inflammation. Although exacerbations of COPD are associated with increased pulmonary and systemic inflammation, determinan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8708472656227daa81594de4959854fa
https://pubmed.ncbi.nlm.nih.gov/16179639

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