Výsledky vyhledávání - "Wayne W. Petko"

Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel acetylcholinesterase inhibitor

Autor: Fernando Camacho, Fink David M, Olsen Gordon Edward, Lawrence L. Martin, Wayne W. Petko, Richard C. Effland, Hugo M. Vargas, Craig P. Smith, David E. Selk, Douglas K. Rush, Klein Joseph Thomas, Peter Allen Nemoto, Larry Davis, Gina M. Bores, James T. Winslow

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:157-162

A series of carbamate analogs of besipirdine (HP 749) was synthesized as potential agents with enhanced cholinomimetic properties for the treatment of Alzheimer's disease. Compound 5a (P10358, 1-[3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a6f4a2e14f8942baf3115f4bd52456a
https://doi.org/10.1016/s0960-894x(96)00592-6

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Serotonergic activity of HP 184: Does spontaneous release have a role?

Autor: Roy Corbett, Wayne W. Petko, Gina M. Bores, Ann T. Woods-Kettelberger, Sathapana Kongsamut, Craig P. Smith, Joachim E. Roehr, Susan M. Chesson

Publikováno v: Neurochemical Research. 21:575-583

Examination of HP 184, [N-n-propyl)-N-(3-fluoro-4-pyridinyl) -1H-3-methylindodel-1-amine hydrochloride], in a variety of tests for serotonergic activity revealed some unique properties of this compound. We report here that 100 microM HP 184 enhanced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b213d4ae8d16fe74ee9237f46982fd62
https://doi.org/10.1007/bf02527756

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Imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase

Autor: Kurys Barbara E, Michael C. Merriman, Olsen Gordon Edward, Fink David M, Mark G. Palermo, Francis P. Huger, Gina M. Bores, Wayne W. Petko, Gerard J. O'Malley

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:625-630

A series of imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates was prepared and evaluated as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen substitution ortho to the carbamate functionality in the eight position r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::028dcf8fee9ea564376729116d03aa6f
https://doi.org/10.1016/0960-894x(96)00072-8

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Substituted (Pyrroloamino)pyridines: Potential Agents for the Treatment of Alzheimer's Disease

Autor: Craig P. Smith, Kevin J. Kapples, Michael Cornfeldt, Olsen Gordon Edward, Richard C. Effland, Wayne W. Petko, Klein Joseph Thomas, Francis P. Huger, Larry Davis

Publikováno v: Journal of Medicinal Chemistry. 39:582-587

A novel series of substituted (pyrroloamino)pyridines was synthesized, and the compounds were evaluated for cholinomimetic-like properties in vitro (inhibition of [3H]quinuclidinyl benzilate binding) and in vivo (reversal of scopolamine-induced demen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0552535476f4fd36fc8fa0943dd818a
https://doi.org/10.1021/jm950644v

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Mechanisms for the increase in electrically stimulated [3H]norepinephrine release from rat cortical slices by N-(n-propyl)-N-(4-pyridinyl)-1H-indol-1-amine

Autor: Richard C. Effland, Craig P. Smith, Joseph Thomas Klein, Joachim E. Roehr, Sathapana Kongsamut, Wayne W. Petko, Francis P. Huger

Publikováno v: Drug Development Research. 32:13-18

N-(n-propyl)-N-(4-pyridinyl)-1H-indol-1-amine (HP 749) is currently in clinical trials for the treatment of Alzheimer's disease (AD). While HP 749 has many pharmacological properties, the biochemical basis for its efficacy in animal models for AD rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3713eb419a4c12a5880dfd4177b7e0c6
https://doi.org/10.1002/ddr.430320104

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ChemInform Abstract: Substituted (Pyrroloamino)pyridines: Potential Agents for the Treatment of Alzheimer′s Disease

Autor: Craig P. Smith, Kevin J. Kapples, Olsen Gordon Edward, Wayne W. Petko, Klein Joseph Thomas, Michael Cornfeldt, Larry Davis, Richard C. Effland, Francis P. Huger

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c28831b45ce110dc816c604de4d750a
https://doi.org/10.1002/chin.199619156

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HP 749 enhances calcium-independent release of [3H]norepinephrine from rat cortical slices and synaptosomes

Autor: Craig P. Smith, Wayne W. Petko, Sathapana Kongsamut, Francis P. Huger

Publikováno v: Neurochemical research. 19(10)

Previous studies have shown that, at concentrations of 1 microM and 10 microM, HP 749 increased electrically-stimulated release of [3H]norepinephrine (NE) from rat cortical slices. These effects were Ca(2+)-dependent, indicating an effect on release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa3b1dde212b13cf9ad8d46ce26ed1d
https://pubmed.ncbi.nlm.nih.gov/7891842

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Aminopyridine carbamic acid esters: synthesis and potential as acetylcholinesterase inhibitors and acetylcholine releasers

Autor: Francis P. Huger, Gregory M. Shutske, Jurcak John G, Hrib Nicholas J, Kevin J. Kapples, Craig P. Smith, John Dick Tomer, Gina M. Bores, Wayne W. Petko

Publikováno v: Journal of pharmaceutical sciences. 81(4)

4-Amino-3-pyridyl carbamates (2a-c) were synthesized as potential acetylcholinesterase inhibitors and acetylcholine releasers on the basis of the reported activity of the analogous N-(4-amino-3-pyridyl)-N',N'-dimethylurea (1). Although 4-amino-3-pyri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c370bebfd56923669d6b90045af0e2d
https://pubmed.ncbi.nlm.nih.gov/1501077

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