Zobrazeno 1 - 10
of 501
pro vyhledávání: '"Wayne W. Hancock"'
Autor:
Tatiana Akimova, Liqing Wang, Zhanna Bartosh, Lanette M. Christensen, Evgeniy Eruslanov, Sunil Singhal, Veenu Aishwarya, Wayne W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Our goal is to improve the outcomes of cancer immunotherapy by targeting FOXP3+ T-regulatory (Treg) cells with a next generation of antisense oligonucleotides (ASO), termed FOXP3 AUMsilence ASO. We performed in vitro experiments with human healthy do
Externí odkaz:
https://doaj.org/article/a96f23f9055b414882bcdbc8711caf2b
Autor:
Lanette M. Christensen, Tatiana Akimova, Liqing Wang, Rongxiang Han, Arabinda Samanta, Eros Di Giorgio, Wayne W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Histone deacetylases 1 and 2 play a major role in the transcriptional regulation of T-regulatory (Treg) cells via interactions with a myriad of coregulatory factors. Sin3a has been well established as a Hdac1/2 cofactor, while its role within Tregs h
Externí odkaz:
https://doaj.org/article/ce5b2e2a49e74bcd86d6e921a8749fc3
Autor:
Elad Lax, Sonia Do Carmo, Yehoshua Enuka, Daniel M. Sapozhnikov, Lindsay A. Welikovitch, Niaz Mahmood, Shafaat A. Rabbani, Liqing Wang, Jonathan P. Britt, Wayne W. Hancock, Yosef Yarden, Moshe Szyf
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The Methyl-CpG-Binding Domain Protein family has been implicated in neurodevelopmental disorders. The Methyl-CpG-binding domain 2 (Mbd2) binds methylated DNA and was shown to play an important role in cancer and immunity. Some evidence linke
Externí odkaz:
https://doaj.org/article/ac756fae07a44e51b83b8e00c01221ca
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
RationaleSarcoidosis is an inflammatory granulomatous disease of unknown etiology with predominant lung involvement. Organ involvement and disease severity, as well as the nature of immune alterations, vary among patients leading to a range of clinic
Externí odkaz:
https://doaj.org/article/0cc69c9fb4d74a2996c9ab15a543d054
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
T-regulatory (Treg) cells display considerable heterogeneity in their responses to various cancers. The functional differences among this cell type are heavily influenced by multiprotein nuclear complexes that control their gene expression. Many such
Externí odkaz:
https://doaj.org/article/ec2355ca2f384aa99810824206094a93
Autor:
David D. Aufhauser, Paul Hernandez, Seth J. Concors, Ciaran O’Brien, Zhonglin Wang, Douglas R. Murken, Arabinda Samanta, Ulf H. Beier, Lauren Krumeich, Tricia R. Bhatti, Yanfeng Wang, Guanghui Ge, Liqing Wang, Shayan Cheraghlou, Florence F. Wagner, Edward B. Holson, Jay H. Kalin, Philip A. Cole, Wayne W. Hancock, Matthew H. Levine
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Histone/protein deacetylases (HDAC) 1 and 2 are typically viewed as structurally and functionally similar enzymes present within various co-regulatory complexes. We tested differential effects of these isoforms in renal ischemia reperfusion
Externí odkaz:
https://doaj.org/article/86bec5fc8fee49dbbb68530f910709b1
Autor:
Peter J. Siska, Jing Jiao, Carina Matos, Katrin Singer, Raffaela S. Berger, Katja Dettmer, Peter J. Oefner, Michelle D. Cully, Zhonglin Wang, William J. QuinnIII, Kristen N. Oliff, Benjamin J. Wilkins, Lanette M. Christensen, Liqing Wang, Wayne W. Hancock, Joseph A. Baur, Matthew H. Levine, Ines Ugele, Roman Mayr, Kathrin Renner, Liang Zhou, Marina Kreutz, Ulf H. Beier
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103734- (2021)
Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce le
Externí odkaz:
https://doaj.org/article/707b3408191f474680381251d1043115
Autor:
Eros Di Giorgio, Liqing Wang, Yan Xiong, Lanette M. Christensen, Tatiana Akimova, Rongxiang Han, Arabinda Samanta, Matteo Trevisanut, Claudio Brancolini, Ulf H. Beier, Wayne W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The Mads/Mef2 (Mef2a/b/c/d) family of transcription factors (TFs) regulates differentiation of muscle cells, neurons and hematopoietic cells. By functioning in physiological feedback loops, Mef2 TFs promote the transcription of their repressor, Hdac9
Externí odkaz:
https://doaj.org/article/84b9b8c42c964606b0b0ab25953d1600
Autor:
William J. Quinn, III, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Liqing Wang, Tatiana Akimova, Alessia Angelin, Patrick M. Schäfer, Michelle D. Cully, Caroline Perry, Piotr K. Kopinski, Lili Guo, Ian A. Blair, Louis R. Ghanem, Michael S. Leibowitz, Wayne W. Hancock, Edmund K. Moon, Matthew H. Levine, Evgeniy B. Eruslanov, Douglas C. Wallace, Joseph A. Baur, Ulf H. Beier
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108500- (2020)
Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effe
Externí odkaz:
https://doaj.org/article/7bafd43031934dc89425250de8164ad0
Autor:
Jay H. Kalin, Muzhou Wu, Andrea V. Gomez, Yun Song, Jayanta Das, Dawn Hayward, Nkosi Adejola, Mingxuan Wu, Izabela Panova, Hye Jin Chung, Edward Kim, Holly J. Roberts, Justin M. Roberts, Polina Prusevich, Jeliazko R. Jeliazkov, Shourya S. Roy Burman, Louise Fairall, Charles Milano, Abdulkerim Eroglu, Charlotte M. Proby, Albena T. Dinkova-Kostova, Wayne W. Hancock, Jeffrey J. Gray, James E. Bradner, Sergio Valente, Antonello Mai, Nicole M. Anders, Michelle A. Rudek, Yong Hu, Byungwoo Ryu, John W. R. Schwabe, Andrea Mattevi, Rhoda M. Alani, Philip A. Cole
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Alteration of the epigenetic landscape has been implicated in several disease processes, where targeting histone modifiers may have therapeutic applications. Here the authors report a bifunctional small molecule inhibitor that simultaneously targets
Externí odkaz:
https://doaj.org/article/879832a39de54eeeb00cc6a12113408e