Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Wayne V. Vedeckis"'
Publikováno v:
Molecular and Cellular Endocrinology. 361:124-132
Glucocorticoid (GC) hormones are used in the treatment of hematopoietic malignancies. When the GC binds to the glucocorticoid receptor (GR) protein, c-Myb and GR are recruited at the Glucocorticoid Response Unit in the DNA. Here we demonstrate that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c97e4e8da992ff5d4eb06d813f327a8
https://doi.org/10.1016/j.mce.2012.03.024
https://doi.org/10.1016/j.mce.2012.03.024
Autor:
Purvaba J. Sarvaiya, Claudia Hernandez, Jason R. Schwartz, Wayne V. Vedeckis, Paulo C. Rodriguez
Publikováno v:
American Journal of Hematology. 87:969-976
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. The current treatment protocol for ALL involves an intense chemotherapy regimen yielding cure rates of nearly 80%. However, new therapies need to be designed not only to increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9ee050c9320203a192d227a4459c09
https://doi.org/10.1002/ajh.23283
https://doi.org/10.1002/ajh.23283
Autor:
Wayne V. Vedeckis, Chuan Dong Geng
Publikováno v:
Biochemistry. 49:8892-8901
Glucocorticoid (GC) hormones induce apoptosis in T-cell and pre-B-cell acute lymphoblastic leukemia (ALL) cells. Steroid-mediated apoptosis requires a threshold level of the glucocorticoid receptor (GR) protein, and increasing the intracellular GR le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1b97b67c24ac2cddb51d841225ef1b
https://doi.org/10.1021/bi1007723
https://doi.org/10.1021/bi1007723
Publikováno v:
Molecular Endocrinology. 22:2624-2642
Glucocorticoid (GC) hormones are widely used in the treatment of acute lymphoblastic leukemia (ALL). Whereas a high level of GC receptor (GR) protein is associated with the sensitivity of ALL cells to steroid-mediated apoptosis, the auto-up-regulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5c7392db64bb8e6be63cd2c18e4325
https://doi.org/10.1210/me.2008-0157
https://doi.org/10.1210/me.2008-0157
Autor:
Wayne V. Vedeckis, Chuan Dong Geng
Publikováno v:
Journal of Biological Chemistry. 280:43264-43271
Steroid auto-regulation of the human glucocorticoid receptor (hGR) 1A promoter in lymphoblast cells resides largely in two DNA elements (footprints 11 and 12). We show here that c-Myb and c-Ets family members (Ets-1/2, PU.1, and Spi-B) control hGR 1A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb4d6b2eaf12cf784671747eaac4082
https://doi.org/10.1074/jbc.m508245200
https://doi.org/10.1074/jbc.m508245200
Publikováno v:
Biochemistry. 44:7395-7405
Alternative splicing of exon 9 in human glucocorticoid receptor (hGR) transcripts yields two native hGR transcripts and proteins, hGRalpha and hGRbeta. We have now identified four novel hGRalpha transcripts that have various deletions of exon 2 seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3320e68ea7e772eae2cb9613e47762
https://doi.org/10.1021/bi047485e
https://doi.org/10.1021/bi047485e
Publikováno v:
Biochemistry. 43:10851-10858
Glucocorticoids up-regulate the glucocorticoid receptor (GR) in the human T-lymphoblast cell line CEM-C7. One mechanism for the up-regulation of the GR protein is the well-known up-regulation of GR transcripts. We have investigated the effect of othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0b51dc340c1973a7430922b751ade5
https://doi.org/10.1021/bi049458u
https://doi.org/10.1021/bi049458u
Autor:
Wayne V. Vedeckis, Chuan Dong Geng
Publikováno v:
Molecular Endocrinology. 18:912-924
At least three promoters (1A, 1B, and 1C) control the expression of mRNA transcripts for the human glucocorticoid receptor (hGR) protein. An hGR 1A promoter/exon sequence (-218/+269) contains at least 12 deoxyribonuclease (DNase) I footprints that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e052951e916f3815eb98232eda7460b
https://doi.org/10.1210/me.2003-0157
https://doi.org/10.1210/me.2003-0157
Autor:
Kim Brint Pedersen, Wayne V. Vedeckis
Publikováno v:
Biochemistry. 42:10978-10990
We have quantified the basal and glucocorticoid-regulated levels of different transcripts from the human glucocorticoid receptor (GR) gene in the T-cell acute lymphoblastic leukemia cell line, CEM-C7, and in the B lymphoblastoid cell line, IM-9. High
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398e74627313961518317d5f744bfed4
https://doi.org/10.1021/bi034651u
https://doi.org/10.1021/bi034651u
Autor:
B. Scott Nunez, Wayne V. Vedeckis
Publikováno v:
Molecular and Cellular Endocrinology. 189:191-199
At least three different promoter regions (1A, 1B, and 1C) are involved in the expression of the human GR gene. Promoters 1B and 1C are found in a 2800 bp region of DNA immediately upstream of the exon 1C transcriptional initiation site. Transcripts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607e38c176cf9573fcac3619d7846320
https://doi.org/10.1016/s0303-7207(01)00676-1
https://doi.org/10.1016/s0303-7207(01)00676-1