Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Wayne S. Lapp"'
Publikováno v:
Proceedings of the National Academy of Sciences. 103:2776-2781
Protein tyrosine phosphatase 1B (PTP-1B) is a ubiquitously expressed cytosolic phosphatase with the ability to dephosphorylate JAK2 and TYK2, and thereby down-regulate cytokine receptor signaling. Furthermore, PTP-1B levels are up-regulated in certai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aabab76398e4c480dbc8b0829785fc
https://doi.org/10.1073/pnas.0508563103
https://doi.org/10.1073/pnas.0508563103
Publikováno v:
Blood. 96:1836-1843
During acute graft-versus-host disease (GVHD) the activation of macrophages (Mφ) is mediated by 2 signals, interferon (IFN)-γ and bacteria-derived lipopolysaccharide (LPS). A cascade of inflammatory responses that includes the release of mediators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a8f4b5d49f237f503a5969a8c275e99
https://doi.org/10.1182/blood.v96.5.1836
https://doi.org/10.1182/blood.v96.5.1836
Publikováno v:
Blood. 96:1836-1843
During acute graft-versus-host disease (GVHD) the activation of macrophages (Mφ) is mediated by 2 signals, interferon (IFN)-γ and bacteria-derived lipopolysaccharide (LPS). A cascade of inflammatory responses that includes the release of mediators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53a343044a42f861b92f79d32a4fe5bb
https://doi.org/10.1182/blood.v96.5.1836.h8001836_1836_1843
https://doi.org/10.1182/blood.v96.5.1836.h8001836_1836_1843
Autor:
Eric S. Muise, Annick Itié, Wayne S. Lapp, Serge Jothy, Michel L. Tremblay, John Wagner, Eva Michaliszyn, Kong E. You-Ten
Publikováno v:
The Journal of Experimental Medicine
The T cell protein tyrosine phosphatase (TC-PTP) is one of the most abundant mammalian tyrosine phosphatases in hematopoietic cells; however, its role in hematopoietic cell function remains unknown. In this report, we investigated the physiological f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f211bfdf20be0795dfe6046310098c
https://doi.org/10.1084/jem.186.5.683
https://doi.org/10.1084/jem.186.5.683
Publikováno v:
Scandinavian Journal of Immunology. 45:294-300
In a previous report the authors demonstrated that acute graft-versus-host disease (GVHD) was associated with pathologic amounts of tumour necrosis factor alpha (TNF-alpha) and the appearance of lipopolysaccharide (LPS) in the blood of GVH reactive m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1de2833822c69132e089bd944254fb
https://doi.org/10.1046/j.1365-3083.1997.d01-404.x
https://doi.org/10.1046/j.1365-3083.1997.d01-404.x
Autor:
Kong E. You-Ten, Wayne S. Lapp
Publikováno v:
Transplantation. 61:76-83
Previously, we demonstrated that immature CD4 + 8 + and mature CD4 + thymocyte populations were selectively eliminated during murine graft-versus-host disease (GVHD) as a consequence of elevated levels of endogenous glucocorticoids. In this report, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9588dc293f4bee3fbca30442651154ee
https://doi.org/10.1097/00007890-199601150-00016
https://doi.org/10.1097/00007890-199601150-00016
Publikováno v:
Clinical and Experimental Immunology. 102:596-602
SUMMARYGVHD in animal models induces severe thymic atrophy as a result of prolonged secretion of high concentrations of adrenal glucocorticoids. In this study we investigated the mechanism responsible for the persistent stimulation of the adrenal gla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0f58c0177a6daa141cf1fc5098017b
https://doi.org/10.1111/j.1365-2249.1995.tb03858.x
https://doi.org/10.1111/j.1365-2249.1995.tb03858.x
Publikováno v:
Cellular Immunology. 163:10-18
The graft-versus-host reaction (GVHR) results in profound, long-lasting immunosuppression characterized by T cell unresponsiveness to antigenic and mitogenic stimuli. In this report, the roles of the protein tyrosine kinases p56lck and p59fyn in GVHR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219f04c294e1281c871b045c8a7bc7f1
https://doi.org/10.1006/cimm.1995.1093
https://doi.org/10.1006/cimm.1995.1093
Publikováno v:
Blood. 84:3965-3973
The nature of the effector cell(s) responsible for the depression of B- cell genesis in the bone marrow of mice undergoing systemic graft- versus-host disease (GVHD) has been examined. Donor C57BL/6 (B6) mice were treated in vivo with either a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a9ce38757f0ed908c6b6bc6ec11cca7
https://doi.org/10.1182/blood.v84.11.3965.bloodjournal84113965
https://doi.org/10.1182/blood.v84.11.3965.bloodjournal84113965
Autor:
Julie Desbarats, Wayne S. Lapp
Publikováno v:
The Journal of Experimental Medicine
The graft-vs.-host reaction (GVHR) results in damage to the epithelial and lymphoid compartments of the thymus and thus in abnormal maturation and function of thymocytes in mice undergoing GVHR. In this report, the effects of GVHR on thymic T cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd3f4fabb2c8d88736289f8e3ae79c0
https://doi.org/10.1084/jem.178.3.805
https://doi.org/10.1084/jem.178.3.805